James E. Rothman

Research.com Recognitions

• 2026 - Research.com Molecular Biology in United States Leader Award
• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2015 - Member of Academia Europaea
• 2013 - Nobel Prize for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells
• 2010 - Kavli Prize, The Kavli Foundation for discovering the molecular basis of neurotransmitter release
• 2010 - E.B. Wilson Medal, American Society for Cell Biology
• 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2002 - Louisa Gross Horwitz Prize, Columbia University
• 2002 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
• 1997 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for his dissection of the biochemical mechanisms by which proteins are transferred from one cellular compartment to another and to the outside world. These mechanisms are important in neurotransmission tissue biogenesis and hormonal secretion.
• 1996 - Canada Gairdner International Award
• 1995 - Member of the National Academy of Medicine (NAM)
• 1994 - Fellow of the American Academy of Arts and Sciences
• 1993 - Member of the National Academy of Sciences

Overview

Best Publications

• SNAP receptors implicated in vesicle targeting and fusion

  Thomas Söllner;Sidney W. Whiteheart;Michael Brunner;Hediye Erdjument-Bromage

  3970
  Citations

• MECHANISMS OF INTRACELLULAR PROTEIN TRANSPORT

  J. E. Rothman

  3353
  Citations

• SNAREpins: Minimal Machinery for Membrane Fusion

  Thomas Weber;Boris V Zemelman;James A McNew;Benedikt Westermann

  2996
  Citations

• Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

  Gero Miesenböck;Dino A. De Angelis;James E. Rothman

  2966
  Citations

• A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

  Thomas Söllner;Mark K. Bennett;Sidney W. Whiteheart;Richard H. Scheller

  2335
  Citations

• Membrane Fusion: Grappling with SNARE and SM Proteins

  Thomas C. Südhof;James E. Rothman

  2240
  Citations

• Protein Sorting by Transport Vesicles

  James E. Rothman;Felix T. Wieland

  1544
  Citations

• Membrane Asymmetry: The nature of membrane asymmetry provides clues to the puzzle of how membranes are assembled.

  James E. Rothman;John Lenard

  1314
  Citations

• Molecular dissection of the secretory pathway

  James E. Rothman;Lelio Orci;Lelio Orci

  1279
  Citations

• Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi.

  Suzanne R. Pfeffer;James E. Rothman

  1241
  Citations

• Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.

  James E. Rothman

  1110
  Citations

• Peptide-binding specificity of the molecular chaperone BiP.

  Gregory C. Flynn;Jan Pohl;Mark T. Flocco;James E. Rothman

  1043
  Citations

• Peptide binding and release by proteins implicated as catalysts of protein assembly

  Gregory C. Flynn;Thomas G. Chappell;James E. Rothman

  1016
  Citations

• Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

  J. Bernd Helms;James E. Rothman

  917
  Citations

• Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

  William E. Balch;William G. Dunphy;William A. Braell;James E. Rothman

  873
  Citations

• Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

  James A. McNew;Francesco Parlati;Ryouichi Fukuda;Robert J. Johnston

  857
  Citations

• Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

  Thomas G. Chappell;William J. Welch;David M. Schlossman;Karen B. Palter

  769
  Citations

• Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport.

  Marc R. Block;Benjamin S. Glick;Celeste A. Wilcox;Felix T. Wieland

  761
  Citations

• SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast.

  Douglas O. Clary;Douglas O. Clary;Irene C. Griff;James E. Rothman

  756
  Citations

• A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

  Duncan W. Wilson;Celeste A. Wilcox;Gregory C. Flynn;Ellson Chen

  746
  Citations