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Biology and Biochemistry

D-Index
53
Citations
8467
World Ranking
16329
National Ranking
6760

Overview

Thomas M. Aune is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Within these broad fields, their work focuses on subfields such as Molecular Biology, Immunology, Hematology, Oncology, and Cardiology and Cardiovascular Medicine.

The main topics of Aune's research include RNA regulation and disease, interferon and immune responses, immune cell function and interaction, autoimmune and inflammatory disorders research, viral infections and immunology research, RNA modifications and cancer, and RNA research and splicing.

Aune has contributed to several peer-reviewed publications, with recent papers including:

  • "Methotrexate and its mechanisms of action in inflammatory arthritis," 2020, Nature Reviews Rheumatology
  • "Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses," 2020, The Journal of Immunology
  • "Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease," 2021, The Journal of Immunology
  • "IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells," 2021, Cell Death and Disease
  • "Increased Development of Th1, Th17, and Th1.17 Cells Under T1 Polarizing Conditions in Juvenile Idiopathic Arthritis," 2022, Frontiers in Immunology

Their work has appeared repeatedly in several venues including:

  • The Journal of Immunology
  • Frontiers in Immunology
  • Nature Reviews Rheumatology
  • Cell Death and Disease
  • Brain Communications

Frequent collaborators in Aune's research include John T. Tossberg, Philip S. Crooke, Krislyn P. Porter, Rachel M. Heinrich, and Tashawna Esmond.

Best Publications

  • Methotrexate and its mechanisms of action in inflammatory arthritis.

    Bruce N. Cronstein;Thomas M. Aune

  • Accumulation of Hypothiocyanite Ion during Peroxidase-Catalyzed Oxidation of Thiocyanate Ion

    Thomas M. Aune;Edwin L. Thomas

  • Cutting Edge: Influence of Tmevpg1, a Long Intergenic Noncoding RNA, on the Expression of Ifng by Th1 Cells

    Sarah P. Collier;Patrick L. Collins;Christopher L. Williams;Mark R. Boothby

  • Cutting edge: Molecular portrait of human autoimmune disease

    Kevin Maas;Sanny Chan;Joel Parker;Angela Slater

  • Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells

    Shaojing Chang;Thomas M Aune

  • The invasive chytrid fungus of amphibians paralyzes lymphocyte responses.

    J. Scott Fites;Jeremy P. Ramsey;Whitney M. Holden;Sarah P. Collier

  • Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl oxidation with antimicrobial action.

    Edwin Thomas;T. M. Aune

  • Expression and functions of long noncoding RNAs during human T helper cell differentiation

    Charles F. Spurlock;John T. Tossberg;Yan Guo;Sarah P. Collier

  • Inhibitors of serotonin synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo.

    T M Aune;H W Golden;K M McGrath

  • Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine.

    T M Aune;K M McGrath;T Sarr;M P Bombara

  • A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells.

    N. J. Olsen;T. Sokka;C. L. Seehorn;B. Kraft

  • Oxidation of protein sulfhydryls by products of peroxidase-catalyzed oxidation of thiocyanate ion.

    Thomas M. Aune;Edwin L. Thomas

  • Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.

    Thomas M. Aune;Sarah L. Pogue

  • Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines.

    M P Bombara;D L Webb;P Conrad;C W Marlor

  • Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction

    Charles F. Spurlock;John T. Tossberg;Brittany K. Matlock;Nancy J. Olsen

  • Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells

    Shaojing Chang;Thomas M. Aune

  • Regulation of the Th1 Genomic Locus from Ifng through Tmevpg1 by T-bet

    Sarah P. Collier;Melodie A. Henderson;John T. Tossberg;Thomas M. Aune

  • Divergent lncRNA GATA3-AS1 Regulates GATA3 Transcription in T-Helper 2 Cells.

    Hunter R. Gibbons;Guzel Shaginurova;Laura C. Kim;Nathaniel Chapman

  • Epigenetics and T helper 1 differentiation.

    Thomas M Aune;Patrick L Collins;Shaojing Chang

  • Differential Transcription Directed by Discrete Gamma Interferon Promoter Elements in Naive and Memory (Effector) CD4 T Cells and CD8 T Cells

    T M Aune;L A Penix;M R Rincón;R A Flavell

Frequent Co-Authors

Nancy J. Olsen
Nancy J. Olsen Penn State Milton S. Hershey Medical Center
Jason H. Moore
Jason H. Moore University of Pennsylvania
Subramaniam Sriram
Subramaniam Sriram Vanderbilt University
Mark Boothby
Mark Boothby Vanderbilt University Medical Center
Richard A. Flavell
Richard A. Flavell Yale University
Chikao Morimoto
Chikao Morimoto Juntendo University
Sebastian Joyce
Sebastian Joyce Vanderbilt University Medical Center
Luc Van Kaer
Luc Van Kaer Vanderbilt University Medical Center
Mercedes Rincon
Mercedes Rincon University of Vermont
Terence S. Dermody
Terence S. Dermody University of Pittsburgh

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