2026 John J. O'Shea: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	151	116	108	74	68	460	92828
Medicine	151	1113	1024	641	577	465	93316

Research.com Recognitions

2026 - Research.com Immunology in United States Leader Award
2025 - Research.com Immunology in United States Leader Award
2018 - AAI-Steinman Award for Human Immunology Research, American Association of Immunologists
2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John J. O'Shea is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with significant contributions to subfields including Immunology, Oncology, Genetics, Molecular Biology, and Rheumatology.

Their work spans diverse topics, with key areas including:

Immune Cell Function and Interaction
Cytokine Signaling Pathways and Interactions
T-cell and B-cell Immunology
IL-33, ST2, and Innate Lymphoid Cell (ILC) Pathways
Immunodeficiency and Autoimmune Disorders
CAR-T cell therapy research
Autoimmune and Inflammatory Disorders Research

O'Shea has published notably in frequent venues such as:

The Journal of Immunology
Genetics in Medicine Open
Nature Immunology
Science Immunology
bioRxiv (Cold Spring Harbor Laboratory)

Some recent publications highlighting O'Shea's research include:

"The JAK-STAT pathway at 30: Much learned, much more to do" (2022) in Cell
"Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach" (2022) in Nature Reviews Rheumatology
"Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus" (2021) in Nature Communications
"BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells" (2021) in Nature Immunology
"Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story" (2023) in Annals of the Rheumatic Diseases

Frequent collaborators of O'Shea include:

Yuka Kanno
Massimo Gadina
Alejandro V. Villarino
Hiroyuki Nagashima
Rachael L. Philips

O'Shea's contributions have been recognized with awards such as the AAI-Steinman Award for Human Immunology Research from the American Association of Immunologists in 2018 and election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

JAKS AND STATS: Biological Implications*

Warren J. Leonard;John J. O'Shea

2338
Citations
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

Arian Laurence;Cristina M. Tato;Todd S. Davidson;Yuka Kanno

1912
Citations
Generation of pathogenic T H 17 cells in the absence of TGF-β signalling

Kamran Ghoreschi;Arian Laurence;Xiang-Ping Yang;Cristina M Tato

1719
Citations
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells.

John J. O’Shea;William E. Paul

1705
Citations
Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman

1653
Citations
GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES

Michael F McDermott;Ivona Aksentijevich;Jérôme Galon;Elizabeth M McDermott

1633
Citations
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention*

John J. O'Shea;Daniella M. Schwartz;Alejandro V. Villarino;Massimo Gadina

1618
Citations
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

John J O'Shea;Massimo Gadina;Robert D Schreiber

1523
Citations
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

Mandy J McGeachy;Yi Chen;Cristina M Tato;Arian Laurence

1322
Citations
Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

Gang Wei;Lai Wei;Jinfang Zhu;Chongzhi Zang

1317
Citations
Janus kinases in immune cell signaling.

Kamran Ghoreschi;Arian Laurence;John J. O’Shea

1291
Citations
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

John J. O'Shea;Robert Plenge;Robert Plenge

1239
Citations
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Daniella M Schwartz;Yuka Kanno;Alejandro Villarino;Michael Ward

1219
Citations
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang

1201
Citations
Mechanisms and consequences of Jak–STAT signaling in the immune system

Alejandro V Villarino;Yuka Kanno;John J O'Shea

1168
Citations
JAKs and STATs in Immunity, Immunodeficiency, and Cancer

John J O'Shea;Steven M Holland;Louis M Staudt

1105
Citations
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

Andre A. Lighvani;David M. Frucht;Dragana Jankovic;Hidehiro Yamane

1085
Citations
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).

P Macchi;A Villa;S Giliani;M G Sacco

1041
Citations
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Jason S Stumhofer;Jonathan S Silver;Arian Laurence;Paige M Porrett

992
Citations
Cytokine Signaling Modules in Inflammatory Responses

John J. O'Shea;Peter J. Murray

960
Citations
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae

948
Citations

Frequent Co-Authors

Yuka Kanno National Institutes of Health

Arian Laurence University of Oxford

Massimo Gadina National Institutes of Health

Alejandro V. Villarino National Institutes of Health

Hong-Wei Sun National Institutes of Health

Kiyoshi Hirahara Chiba University

Fabio Candotti National Institutes of Health

Kamran Ghoreschi Charité - University Medicine Berlin

Jérôme Galon Inserm

Lothar Hennighausen National Institutes of Health

External Links

Wikipedia of John J. O'Shea Personal website of John J. O'Shea

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