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Biology and Biochemistry

D-Index
73
Citations
30727
World Ranking
5802
National Ranking
2745

Overview

Massimo Gadina is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on medicine with significant work in immunology and microbiology. Specific subfields of study include immunology, rheumatology, oncology, molecular biology, and genetics.

The scientist's research topics encompass a variety of areas related to immune function and disorders. Key topics include:

  • Cytokine Signaling Pathways and Interactions
  • Immune Cell Function and Interaction
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Inflammasome and immune disorders
  • IL-33, ST2, and ILC Pathways

Massimo Gadina has contributed to publications in several notable venues. These include:

  • Annals of the Rheumatic Diseases
  • Arthritis & Rheumatology
  • New England Journal of Medicine
  • Cell
  • Nature Communications

Frequent collaborators in their research efforts include Wanxia Li Tsai, John J. O'Shea, Mariana J. Kaplan, Ivona Aksentijevich, and Daniel L. Kastner.

Among recent papers authored or co-authored by Massimo Gadina are:

  • "Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease," 2020, New England Journal of Medicine
  • "The JAK-STAT pathway at 30: Much learned, much more to do," 2022, Cell
  • "Type 2 immunity in the skin and lungs," 2020, Allergy
  • "Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS," 2021, Arthritis & Rheumatology
  • "Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus," 2021, Nature Communications

Best Publications

  • GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES

    Michael F McDermott;Ivona Aksentijevich;Jérôme Galon;Elizabeth M McDermott

  • The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention*

    John J. O'Shea;Daniella M. Schwartz;Alejandro V. Villarino;Massimo Gadina

  • Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

    John J O'Shea;Massimo Gadina;Robert D Schreiber

  • Activated STING in a Vascular and Pulmonary Syndrome

    Y. Liu;A.A. Jesus;B. Marrero;D. Yang

  • JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

    Daniella M Schwartz;Yuka Kanno;Alejandro Villarino;Michael Ward

  • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

    Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  • T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

    Andre A. Lighvani;David M. Frucht;Dragana Jankovic;Hidehiro Yamane

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    David B. Beck;Marcela A. Ferrada;Keith A. Sikora;Amanda K. Ombrello

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease

    Elaine F. Remmers;Fulya Cosan;Yohei Kirino;Michael J. Ombrello

  • Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

    Kamran Ghoreschi;Michael I. Jesson;Xiong Li;Jamie L. Lee

  • Erratum to: JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

    Shubhasree Banerjee;Ann Biehl;Massimo Gadina;Sarfaraz Hasni

  • Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

    Khuong B. Nguyen;Wendy T. Watford;Rachelle Salomon;Sigrun R. Hofmann

  • Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

    Qing Zhou;Hongying Wang;Daniella M. Schwartz;Monique Stoffels

  • Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases

    Daniella M. Schwartz;Michael Bonelli;Massimo Gadina;John J. O'Shea

  • Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.

    Davide Agnello;Carla S. R. Lankford;Jay Bream;Akio Morinobu

  • Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

    Valentino Parravicini;Valentino Parravicini;Massimo Gadina;Martina Kovarova;Martina Kovarova;Sandra Odom

  • JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

    Gina A. Montealegre Sanchez;Adam L Reinhardt;Suzanne Ramsey;Helmut Wittkowski

  • Super-enhancers delineate disease-associated regulatory nodes in T cells

    Golnaz Vahedi;Yuka Kanno;Yasuko Furumoto;Kan Jiang

  • Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.

    Denis Franchimont;Jérôme Galon;Massimo Gadina;Roberta Visconti

Frequent Co-Authors

John J. O'Shea
John J. O'Shea National Institutes of Health
Daniel L. Kastner
Daniel L. Kastner National Institutes of Health
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Raphaela Goldbach-Mansky
Raphaela Goldbach-Mansky National Institute of Allergy and Infectious Diseases
Elaine F. Remmers
Elaine F. Remmers National Institutes of Health
Ahmet Gül
Ahmet Gül Istanbul University
Yuka Kanno
Yuka Kanno National Institutes of Health
Robert A. Colbert
Robert A. Colbert National Institutes of Health
Fabio Candotti
Fabio Candotti National Institutes of Health

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