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Best Scientists
2025
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Immunology
USA
2026

D-Index & Metrics

Best Scientists

D-Index
235
Citations
213751
World Ranking
80
National Ranking
58

Immunology

D-Index
238
Citations
216382
World Ranking
4
National Ranking
3

Medicine

D-Index
238
Citations
216526
World Ranking
50
National Ranking
38

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2022 - Research.com Immunology in United States Leader Award
  • 2011 - Royal Netherlands Academy of Arts and Sciences
  • 2009 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 1998 - Member of the National Academy of Sciences
  • 1986 - Oswald Avery Award, Infectious Diseases Society of America
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Charles A. Dinarello is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily focuses on medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology.

Their main subfields of study include immunology, molecular biology, oncology, epidemiology, and surgery. The topics Charles A. Dinarello has extensively worked on are inflammasome and immune disorders, IL-33, ST2, and ILC pathways, immune cell function and interaction, immune cells in cancer, psoriasis treatment and pathogenesis, cytokine signaling pathways and interactions, and immune responses and vaccinations.

Charles A. Dinarello has published frequently in several scientific venues, including:

  • Frontiers in Immunology
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cytokine
  • Journal of Biological Chemistry

The scientist's recent publications include:

  • Interleukins in cancer: from biology to therapy, 2021, Nature Reviews. Cancer
  • Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease, 2020, Circulation Research
  • Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases, 2021, Autoimmunity Reviews
  • The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease, 2020, Proceedings of the National Academy of Sciences
  • Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial, 2020, The Lancet Rheumatology

Frequent collaborators in their research include:

  • Leo A. B. Joosten
  • Dennis M. de Graaf
  • Isak W. Tengesdal
  • Carlo Marchetti
  • Mihai G. Netea

Charles A. Dinarello has been recognized with several awards during their career, such as:

  • Royal Netherlands Academy of Arts and Sciences (2011)
  • Albany Medical Center Prize in Medicine and Biomedical Research (2009)
  • Member of the National Academy of Sciences (1998)
  • Oswald Avery Award, Infectious Diseases Society of America (1986)
  • Member of the Association of American Physicians

Best Publications

  • Biologic basis for interleukin-1 in disease

    Charles A. Dinarello

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • Immunological and Inflammatory Functions of the Interleukin-1 Family

    Charles A. Dinarello

  • Interleukin-1 and interleukin-1 antagonism.

    Charles A. Dinarello

  • Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

    Michael L. Dustin;Robert Rothlein;Atul K. Bhan;Charles A. Dinarello

  • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

    Charles A. Dinarello

  • Impact of Basic Research On Tomorrow's MedicineProinflammatory Cytokines

    Charles A. Dinarello

  • Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

    Charles A. Dinarello;Anna Simon;Jos W. M. van der Meer

  • Biology of interleukin 1.

    Charles A. Dinarello

  • Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones

    H Besedovsky;A del Rey;E Sorkin;CA Dinarello

  • The Interleukin-1 Family: Back to the Future

    Cecilia Garlanda;Charles A. Dinarello;Alberto Mantovani

  • Detection of circulating tumor necrosis factor after endotoxin administration.

    Hamish R. Michie;Kirk R. Manogue;David R. Spriggs;Arthur Revhaug

  • Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

    Charles A. Dinarello;Joseph G. Cannon;Sheldon M. Wolff;Harry A. Bernheim

  • Overview of the IL-1 family in innate inflammation and acquired immunity.

    Charles A. Dinarello;Charles A. Dinarello

  • Interleukin-1 and its biologically related cytokines.

    Charles A. Dinarello

  • Interleukin-1 and the pathogenesis of the acute-phase response.

    Charles A. Dinarello

  • Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

    Philip E. Auron;Andrew C. Webb;Lanny J. Rosenwasser;Steven F. Mucci

  • The Role of Interleukin-1 in Disease

    Charles A. Dinarello;Sheldon M. Wolff

  • IL-1 is required for tumor invasiveness and angiogenesis

    Elena Voronov;Dror S. Shouval;Yakov Krelin;Emanuela Cagnano

  • Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

    Thomas M. Folks;Jesse Justement;Audrey Kinter;Charles A. Dinarello

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

Leo A. B. Joosten
Leo A. B. Joosten Radboud University
Mihai G. Netea
Mihai G. Netea Radboud University
Soo-Hyun Kim
Soo-Hyun Kim Konkuk University
Daniela Novick
Daniela Novick Weizmann Institute of Science
Giamila Fantuzzi
Giamila Fantuzzi University of Illinois at Chicago
Menachem Rubinstein
Menachem Rubinstein Weizmann Institute of Science
Jos W. M. van der Meer
Jos W. M. van der Meer Radboud University Medical Center
Thomas Mandrup-Poulsen
Thomas Mandrup-Poulsen University of Copenhagen
Frank L. van de Veerdonk
Frank L. van de Veerdonk Radboud University
Antonio Abbate
Antonio Abbate University of Virginia

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