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Leo A. B. Joosten

Leo A. B. Joosten

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Immunology
Netherlands
2026
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Medicine
Netherlands
2023

D-Index & Metrics

Immunology

D-Index
161
Citations
118458
World Ranking
74
National Ranking
2

Medicine

D-Index
161
Citations
118680
World Ranking
738
National Ranking
30

Research.com Recognitions

  • 2026 - Research.com Immunology in Netherlands Leader Award
  • 2025 - Research.com Immunology in Netherlands Leader Award
  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2022 - Research.com Immunology in Netherlands Leader Award

Overview

Leo A. B. Joosten is affiliated with Radboud University in the Netherlands. Their research spans multiple disciplines including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

The scientist's work focuses on key topics such as:

  • Immune responses and vaccinations
  • Immune cells in cancer
  • Diabetes and associated disorders
  • Inflammasome and immune disorders
  • COVID-19 impact on reproduction
  • Gout, hyperuricemia, and uric acid
  • Epigenetics and DNA methylation

Their research covers several subfields within these topics, including:

  • Immunology
  • Molecular Biology
  • Infectious Diseases
  • Genetics
  • Epidemiology

Leo A. B. Joosten has contributed to publications in a variety of journals and platforms, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • University of Groningen research database (University of Groningen / Centre for Information Technology)
  • iScience
  • Nature Immunology

Collaborations are a significant aspect of their research, often co-authoring with:

  • Mihai G. Netea
  • Simone J.C.F.M. Moorlag
  • Yang Li
  • Valerie A. C. M. Koeken
  • Martin Jaeger

Recent notable papers include:

  • Defining trained immunity and its role in health and disease, 2020, Nature Reviews. Immunology
  • Presence of Genetic Variants Among Young Men With Severe COVID-19, 2020, JAMA
  • Trained immunity, tolerance, priming and differentiation: distinct immunological processes, 2020, Nature Immunology
  • BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment, 2020, Cell Host & Microbe
  • The Intersection of Epigenetics and Metabolism in Trained Immunity, 2020, Immunity

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Trained immunity: A program of innate immune memory in health and disease

    Mihai G. Netea;Leo A. B. Joosten;Eicke Latz;Kingston H. G. Mills

  • Defining trained immunity and its role in health and disease

    Mihai G. Netea;Mihai G. Netea;Jorge Domínguez-Andrés;Luis B. Barreiro;Luis B. Barreiro;Triantafyllos Chavakis;Triantafyllos Chavakis

  • mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

    Shih-Chin Cheng;Jessica Quintin;Robert A. Cramer;Kelly M. Shepardson

  • Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

    Johanneke Kleinnijenhuis;Jessica Quintin;Frank Preijers;Leo A. B. Joosten

  • Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

    Sadia Saeed;Jessica Quintin;Hindrik H. D. Kerstens;Nagesha A. Rao

  • Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.

    Serena Sanna;Natalie R van Zuydam;Natalie R van Zuydam;Anubha Mahajan;Alexander Kurilshikov

  • Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

    Jessica Quintin;Sadia Saeed;Joost H.A. Martens;Evangelos J. Giamarellos-Bourboulis

  • Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

    Melanie Schirmer;Melanie Schirmer;Sanne P. Smeekens;Hera Vlamakis;Martin Jaeger

  • BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

    Rob J.W. Arts;Simone J.C.F.M. Moorlag;Boris Novakovic;Yang Li

  • Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

    Ioannis Mitroulis;Klara Ruppova;Baomei Wang;Lan Sun Chen

  • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

    Gosia Trynka;Karen A Hunt;Nicholas A Bockett;Jihane Romanos

  • Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

    Anette Christ;Anette Christ;Patrick Günther;Mario A.R. Lauterbach;Peter Duewell

  • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.

    Erik Lubberts;Marije I. Koenders;Birgitte Oppers-Walgreen;Liduine van den Bersselaar

  • Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.

    Mihea G Netea;Mihea G Netea;Claudia Annelie Nold-Petry;Marcel F Nold;Leo A B Joosten

  • Toll-like receptor 2 controls expansion and function of regulatory T cells.

    Roger P.M. Sutmuller;Martijn H.M.G.M. den Brok;Matthijs Kramer;Erik J. Bennink

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

    Bart Ferwerda;Gerben Ferwerda;Theo S. Plantinga;Janet A. Willment

  • The effect of host genetics on the gut microbiome

    Marc Jan Bonder;Alexander Kurilshikov;Alexander Kurilshikov;Ettje F Tigchelaar;Zlatan Mujagic

  • Inflammasome is a central player in the induction of obesity and insulin resistance

    Rinke Stienstra;Janna A. Van Diepen;Cees J. Tack;Hasan Zaki

Frequent Co-Authors

Mihai G. Netea
Mihai G. Netea Radboud University
Jos W. M. van der Meer
Jos W. M. van der Meer Radboud University Medical Center
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
Frank L. van de Veerdonk
Frank L. van de Veerdonk Radboud University
Marije Oosting
Marije Oosting Radboud University
Wim B. van den Berg
Wim B. van den Berg Radboud University
Bart Jan Kullberg
Bart Jan Kullberg Radboud University
Niels P. Riksen
Niels P. Riksen Radboud University
Ramnik J. Xavier
Ramnik J. Xavier Broad Institute
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

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