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Timothy R D J Radstake

Timothy R D J Radstake

D-Index & Metrics

Immunology

D-Index
81
Citations
24694
World Ranking
1560
National Ranking
58

Overview

Timothy R D J Radstake is affiliated with Utrecht University in the Netherlands and has contributed extensively to medical research, particularly within the field of rheumatology. Their work spans a variety of subfields including immunology, genetics, pathology and forensic medicine, and molecular biology. The main focus of their research involves rheumatoid arthritis and related autoimmune and inflammatory disorders.

Radstake's publication record includes significant papers such as:

  • EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors, 2020, Annals of the Rheumatic Diseases
  • Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis, 2020, Arthritis & Rheumatology
  • Machine learning in rheumatology approaches the clinic, 2020, Nature Reviews Rheumatology
  • Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation, 2021, European Journal of Cancer
  • Efficacy and Safety of ABBV-3373, a Novel Anti-Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody-Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Controlled Proof-of-Concept Phase IIa Trial, 2022, Arthritis & Rheumatology

Frequent publication venues for Radstake's research include:

  • Annals of the Rheumatic Diseases
  • Arthritis & Rheumatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Lara D. Veeken

Radstake has collaborated with several researchers, prominently including:

  • Aridaman Pandit
  • Weiyang Tao
  • Hendrik Schulze-Koops
  • Olivier Lambotte
  • Xavier Mariette

The scientist's main fields of study center on medicine and especially rheumatology, supported by subfields such as immunology and genetics. Their research addresses clinical challenges and mechanisms related to autoimmune conditions, with topics that cover:

  • Rheumatoid Arthritis Research and Therapies
  • Systemic Lupus Erythematosus Research
  • Chronic Lymphocytic Leukemia Research
  • Autoimmune and Inflammatory Disorders Research
  • Systemic Sclerosis and Related Diseases
  • Spondyloarthritis Studies and Treatments
  • T-cell and B-cell Immunology

Best Publications

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages

    E R Vossenaar;T R D Radstake;A van der Heijden;M A M van Mansum

  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

    Shahla Abdollahi-Roodsaz;Leo A.B. Joosten;Marije I. Koenders;Isabel Devesa

  • Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.

    Charles Antoine Dutertre;Charles Antoine Dutertre;Etienne Becht;Sergio Erdal Irac;Sergio Erdal Irac;Ahad Khalilnezhad;Ahad Khalilnezhad

  • Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

    L. Van Bon;L. Van Bon;A. J. Affandi;A. J. Affandi;J. Broen;J. Broen;R. B. Christmann

  • Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

    T.R.D.J. Radstake;M. Svenson;A.M.M. Eijsbouts;F.H.J. van den Hoogen

  • Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.

    C.A. Ambarus;S. Krausz;M. van der Eijk;J. Hamann

  • Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

    Timothy R.D.J. Radstake;Olga Y Gorlova;Blanca Rueda;Jose Ezequiel Martin

  • Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

    Alexandra Zhernakova;Alexandra Zhernakova;Alexandra Zhernakova;Eli A. Stahl;Eli A. Stahl;Gosia Trynka;Soumya Raychaudhuri

  • Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.

    Timothy R D J Radstake;Mieke F Roelofs;Yvonne M Jenniskens;Birgitte Oppers-Walgreen

  • IL-32, a proinflammatory cytokine in rheumatoid arthritis.

    Leo A. B. Joosten;Mihai G. Netea;Soo-Hyun Kim;Do-Young Yoon

  • Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.

    Shahla Abdollahi-Roodsaz;Leo A. B. Joosten;Mieke F. Roelofs;Timothy R. D. J. Radstake

  • Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis

    Mieke F. Roelofs;Wilbert C. Boelens;Leo A. B. Joosten;Shahla Abdollahi-Roodsaz

  • Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis.

    C Popa;M G Netea;T Radstake;J W M Van der Meer

  • Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.

    Swati Bhattacharyya;Kathleen Kelley;Denisa S. Melichian;Zenshiro Tamaki

  • Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

    Alexandra Zhernakova;Behrooz Z. Alizadeh;Behrooz Z. Alizadeh;Marianna Bevova;Miek A. van Leeuwen

  • Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor.

    Timothy R. D. J. Radstake;Fred C. G. J. Sweep;Paco Welsing;Barbara Franke

  • EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.

    Marie Kostine;Axel Finckh;Clifton O. Bingham;Karen Visser

  • The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

    Timothy R. D. J. Radstake;Timothy R. D. J. Radstake;Lenny van Bon;Lenny van Bon;Jasper Broen;Jasper Broen;Anila Hussiani

  • Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy

    Olga Gorlova;Jose Ezequiel Martin;Blanca Rueda;Bobby P C Koeleman

Frequent Co-Authors

Joel A G van Roon
Joel A G van Roon University Medical Center Utrecht
Bobby P.C. Koeleman
Bobby P.C. Koeleman Utrecht University
Jane Worthington
Jane Worthington University of Manchester
Ariane L. Herrick
Ariane L. Herrick University of Manchester
Torsten Witte
Torsten Witte Hannover Medical School
Pilar Barrera
Pilar Barrera Radboud University Nijmegen Medical Centre
Christopher P. Denton
Christopher P. Denton University College London
Javier Martín
Javier Martín Spanish National Research Council
Wim B. van den Berg
Wim B. van den Berg Radboud University
Maureen D. Mayes
Maureen D. Mayes The University of Texas at Austin

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