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Lars Klareskog

Lars Klareskog

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Immunology
Sweden
2026
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Medicine
Sweden
2023

D-Index & Metrics

Immunology

D-Index
157
Citations
92617
World Ranking
95
National Ranking
1

Medicine

D-Index
158
Citations
94319
World Ranking
855
National Ranking
19

Research.com Recognitions

  • 2026 - Research.com Immunology in Sweden Leader Award
  • 2025 - Research.com Immunology in Sweden Leader Award
  • 2023 - Research.com Medicine in Sweden Leader Award
  • 2022 - Research.com Immunology in Sweden Leader Award

Overview

Lars Klareskog is affiliated with the Karolinska Institute in Sweden and has a significant body of research primarily in the field of Medicine with a focus on Rheumatology, Immunology, Radiology, Nuclear Medicine and Imaging, Genetics, and Pathology and Forensic Medicine. Their work addresses a range of complex issues in autoimmune and inflammatory diseases.

The scientist's research covers several main topics, including:

  • Rheumatoid Arthritis Research and Therapies
  • Systemic Lupus Erythematosus Research
  • Monoclonal and Polyclonal Antibodies Research
  • Autoimmune and Inflammatory Disorders Research
  • T-cell and B-cell Immunology
  • Lymphoma Diagnosis and Treatment
  • Chronic Lymphocytic Leukemia Research

Among the recent publications authored or co-authored by Klareskog are:

  • "Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets," 2023, Nature Immunology
  • "Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis," 2022, Nature Genetics
  • "FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease," 2020, Nature
  • "Impact of the COVID-19 pandemic on morbidity and mortality in patients with inflammatory joint diseases and in the general population: a nationwide Swedish cohort study," 2021, Annals of the Rheumatic Diseases
  • "The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis," 2020, Journal of Internal Medicine

Klareskog frequently collaborates with other researchers, including Lars Alfredsson, Leonid Padyukov, Vivianne Malmström, Saedís Saevarsdóttir, and Johan Askling. These collaborations have contributed to a significant output in well-regarded venues.

The most common publication venues for Klareskog include:

  • Annals of the Rheumatic Diseases
  • Arthritis & Rheumatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Lara D. Veeken
  • Arthritis Research & Therapy

Lars Klareskog's research contributions span genetics, immunology, and clinical studies related to autoimmune diseases, with an emphasis on rheumatoid arthritis and related inflammatory disorders. This multidisciplinary approach involves both genetic analyses and studies of environmental interactions, contributing to ongoing understanding of disease mechanisms and potential therapeutic targets.

Best Publications

  • Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

    Lars Klareskog;Désirée van der Heijde;Julien P de Jager;Andrew Gough

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

    Daniel Tracey;Lars Klareskog;Eric H. Sasso;Jochen G. Salfeld

  • A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

    Lars Klareskog;Patrik Stolt;Karin Lundberg;Henrik Källberg

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Phil H. Lee;Verneri Anttila;Hyejung Won;Yen-Chen A. Feng

  • STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham

  • EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

    Bernard Combe;Robert Landewé;Cedric Lukas;Horatio D Bolosiu

  • Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    Hunna J. Watson;Hunna J. Watson;Hunna J. Watson;Zeynep Yilmaz;Laura M. Thornton;Christopher Hübel;Christopher Hübel

  • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

    Soumya Raychaudhuri;Cynthia Sandor;Eli A. Stahl;Eli A. Stahl;Jan Freudenberg

  • Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

    Yun Liu;Martin J Aryee;Leonid Padyukov;M Daniele Fallin;M Daniele Fallin

  • Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis

    Eva Baecklund;Anastasia Iliadou;Johan Askling;Anders Ekbom;Anders Ekbom

  • TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

    Robert M. Plenge;Mark Seielstad;Leonid Padyukov;Annette T. Lee

  • A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis

    Leonid Padyukov;Camilla Silva;Patrik Stolt;Lars Alfredsson

  • Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases

    P Stolt;C Bengtsson;B Nordmark;S Lindblad

  • Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

    Ulrike Harre;Dan Georgess;Holger Bang;Aline Bozec

  • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

    Steve Eyre;John Bowes;John Bowes;Dorothée Diogo;Dorothée Diogo;Annette Lee

  • Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.

    Désirée van der Heijde;Lars Klareskog;Vicente Rodriguez-Valverde;Catalin Codreanu

  • Incidence of Cancer Among Patients With Rheumatoid Arthritis

    Gloria Gridley;Joseph K. McLaughlin;Anders Ekbom;Lars Klareskog

  • Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study

    Edward C. Keystone;Mark C. Genovese;Lars Klareskog;Elizabeth C. Hsia

  • Rheumatoid arthritis

    Unknown

Frequent Co-Authors

Lars Alfredsson
Lars Alfredsson Karolinska Institute
Leonid Padyukov
Leonid Padyukov Karolinska Institute
Rikard Holmdahl
Rikard Holmdahl Karolinska Institute
Anca I. Catrina
Anca I. Catrina Karolinska University Hospital
Vivianne Malmström
Vivianne Malmström Karolinska University Hospital
Johan Rönnelid
Johan Rönnelid Uppsala University
Robert M. Plenge
Robert M. Plenge Bristol Myers Squibb
Peter K. Gregersen
Peter K. Gregersen Feinstein Institute for Medical Research
Johan Askling
Johan Askling Karolinska Institute
Jane Worthington
Jane Worthington University of Manchester

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