2012 - Member of the National Academy of Medicine (NAM)
2010 - Member of the National Academy of Sciences
Member of the Association of American Physicians
Daniel L. Kastner mostly deals with Immunology, Genetics, Familial Mediterranean fever, Inflammation and Inflammasome. His research in Immunology intersects with topics in Mutation, Single-nucleotide polymorphism, Allele and Locus. His biological study spans a wide range of topics, including Pyrin domain and MEFV.
His research integrates issues of Tumor necrosis factor alpha, Interleukin, Innate immune system and Lipopolysaccharide in his study of Inflammation. The various areas that Daniel L. Kastner examines in his Inflammasome study include Acquired immune system, Cancer research and Cell biology. His research investigates the connection between Rheumatoid arthritis and topics such as Arthritis that intersect with problems in PTPN22.
His scientific interests lie mostly in Immunology, Genetics, Familial Mediterranean fever, Internal medicine and Gene. Immunology is closely attributed to Disease in his study. His is involved in several facets of Genetics study, as is seen by his studies on Haplotype, Single-nucleotide polymorphism, Allele, Genotype and Locus.
In his work, NALP3, Signal transducing adaptor protein and Mutation is strongly intertwined with Pyrin domain, which is a subfield of Familial Mediterranean fever. The study incorporates disciplines such as Gastroenterology and Endocrinology in addition to Internal medicine. Daniel L. Kastner combines subjects such as Cancer research and Cell biology with his study of Inflammasome.
Immunology, Cell biology, Genetics, Inflammation and Familial Mediterranean fever are his primary areas of study. His Immunology research integrates issues from Pyoderma gangrenosum and Disease. The Cell biology study combines topics in areas such as Chromatin, Ubiquitin, Degranulation and Mast cell.
His study in Cohort extends to Genetics with its themes. His work deals with themes such as Caspase 3, Neuroscience, Neurological injury and Neurodegeneration, which intersect with Inflammation. His Familial Mediterranean fever study integrates concerns from other disciplines, such as Haploinsufficiency and MEFV.
Daniel L. Kastner focuses on Immunology, Inflammation, Proinflammatory cytokine, Cell biology and Tumor necrosis factor alpha. His work carried out in the field of Immunology brings together such families of science as Adenosine and Adenosine deaminase deficiency. Daniel L. Kastner interconnects Caspase 3, Programmed cell death, Caspase 8 and Kinase activity in the investigation of issues within Inflammation.
His Proinflammatory cytokine study which covers Cytokine that intersects with Exome sequencing, Immunodeficiency, Autoinflammatory Syndrome and Immunophenotyping. His Cell biology study incorporates themes from Acquired immune system, Familial Mediterranean fever, Protein oligomerization and MEFV. His Tumor necrosis factor alpha research is multidisciplinary, incorporating perspectives in Necrosis, Treatment strategy, ADENOSINE DEAMINASE 2 and Adenosine Deaminase 2 Deficiency.
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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Ann B. Begovich;Victoria E H Carlton;Lee A. Honigberg;Steven J. Schrodi.
American Journal of Human Genetics (2004)
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C Coll;Avril A B Robertson;Jae Jin Chae;Sarah C Higgins.
Nature Medicine (2015)
GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES
Michael F McDermott;Ivona Aksentijevich;Jérôme Galon;Elizabeth M McDermott.
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie.
Nature Genetics (2010)
STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham.
The New England Journal of Medicine (2007)
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
Seth L. Masters;Anna Simon;Ivona Aksentijevich;Daniel L. Kastner.
Annual Review of Immunology (2009)
TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Robert M. Plenge;Mark Seielstad;Leonid Padyukov;Annette T. Lee.
The New England Journal of Medicine (2007)
Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition
Raphaela Goldbach-Mansky;Natalie J Dailey;Scott W Canna;Ana Gelabert.
The New England Journal of Medicine (2006)
Activated STING in a Vascular and Pulmonary Syndrome
Y. Liu;A.A. Jesus;B. Marrero;D. Yang.
The New England Journal of Medicine (2014)
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey.
The New England Journal of Medicine (2009)
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