World's Best Scientists 2026 revealed!

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Immunology

D-Index
119
Citations
56748
World Ranking
341
National Ranking
215

Medicine

D-Index
119
Citations
57216
World Ranking
3867
National Ranking
2114

Research.com Recognitions

  • 2012 - Member of the National Academy of Medicine (NAM)
  • 2010 - Member of the National Academy of Sciences
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Daniel L. Kastner is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Subfields of particular interest include molecular biology, immunology, rheumatology, genetics, and hematology.

The scientist has explored numerous topics within their work, including inflammasome and immune disorders, otitis media and relapsing polychondritis, immunodeficiency and autoimmune disorders, autoimmune and inflammatory disorders research, interferon and immune responses, systemic lupus erythematosus research, and adenosine and purinergic signaling.

Their recent papers illustrate involvement in research on somatic mutations, autoinflammatory diseases, and hematologic manifestations. Notable papers include:

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease, 2020, New England Journal of Medicine
  • Strategic vision for improving human health at The Forefront of Genomics, 2020, Nature
  • Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS, 2021, Arthritis & Rheumatology
  • Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1, 2021, Blood Advances
  • Estimated Prevalence and Clinical Manifestations of UBA1 Variants Associated With VEXAS Syndrome in a Clinical Population, 2023, JAMA

Frequent coauthors in their research include:

  • Amanda K. Ombrello
  • Ivona Aksentijevich
  • David B. Beck
  • Peter C. Grayson
  • Marcela A. Ferrada

The scientist's publications often appear in specific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of the Rheumatic Diseases
  • Blood
  • Arthritis & Rheumatology
  • Journal of Allergy and Clinical Immunology

Daniel L. Kastner has been recognized with several academic honors, including membership in the National Academy of Sciences (2010), the National Academy of Medicine (2012), and the Association of American Physicians.

Best Publications

  • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    Rebecca C Coll;Avril A B Robertson;Jae Jin Chae;Sarah C Higgins

  • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

    Ann B. Begovich;Victoria E H Carlton;Lee A. Honigberg;Steven J. Schrodi

  • GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES

    Michael F McDermott;Ivona Aksentijevich;Jérôme Galon;Elizabeth M McDermott

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Activated STING in a Vascular and Pulmonary Syndrome

    Y. Liu;A.A. Jesus;B. Marrero;D. Yang

  • STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham

  • Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

    Seth L. Masters;Anna Simon;Ivona Aksentijevich;Daniel L. Kastner

  • The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

    Geun-Shik Lee;Naeha Subramanian;Andrew I. Kim;Ivona Aksentijevich

  • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

    Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    David B. Beck;Marcela A. Ferrada;Keith A. Sikora;Amanda K. Ombrello

  • TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

    Robert M. Plenge;Mark Seielstad;Leonid Padyukov;Annette T. Lee

  • Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

    Raphaela Goldbach-Mansky;Natalie J Dailey;Scott W Canna;Ana Gelabert

  • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

    Ariel C. Bulua;Anna Simon;Ravikanth Maddipati;Martin Pelletier

  • De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

    Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • A guiding map for inflammation

    Mihai G Netea;Frances Balkwill;Michel Chonchol;Fabio Cominelli

  • Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease

    Elaine F. Remmers;Fulya Cosan;Yohei Kirino;Michael J. Ombrello

  • The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

    Jae Jin Chae;Geryl Wood;Seth L. Masters;Katharina Richard

  • Common variants at CD40 and other loci confer risk of rheumatoid arthritis

    Soumya Raychaudhuri;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Annette T Lee;Rachel Hackett

  • EULAR recommendations for the management of familial Mediterranean fever

    Seza Ozen;Erkan Demirkaya;Burak Erer;Avi Livneh

  • Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

    Robert M. Plenge;Leonid Padyukov;Elaine F. Remmers;Shaun Purcell

Frequent Co-Authors

Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Elaine F. Remmers
Elaine F. Remmers National Institutes of Health
Raphaela Goldbach-Mansky
Raphaela Goldbach-Mansky National Institute of Allergy and Infectious Diseases
Peter K. Gregersen
Peter K. Gregersen Feinstein Institute for Medical Research
Lindsey A. Criswell
Lindsey A. Criswell National Institutes of Health
Elon Pras
Elon Pras Tel Aviv University
Christopher I. Amos
Christopher I. Amos Baylor College of Medicine
Massimo Gadina
Massimo Gadina National Institutes of Health
Michael F. Seldin
Michael F. Seldin University of California, Davis
Robert M. Plenge
Robert M. Plenge Bristol Myers Squibb

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