H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Immunology D-index 73 Citations 29,759 128 World Ranking 897 National Ranking 496
Medicine D-index 88 Citations 36,255 177 World Ranking 6458 National Ranking 3567

Research.com Recognitions

Awards & Achievements

2012 - Member of the National Academy of Medicine (NAM)

2010 - Member of the National Academy of Sciences

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Mutation
  • Genetics

Daniel L. Kastner mostly deals with Immunology, Genetics, Familial Mediterranean fever, Inflammation and Inflammasome. His research in Immunology intersects with topics in Mutation, Single-nucleotide polymorphism, Allele and Locus. His biological study spans a wide range of topics, including Pyrin domain and MEFV.

His research integrates issues of Tumor necrosis factor alpha, Interleukin, Innate immune system and Lipopolysaccharide in his study of Inflammation. The various areas that Daniel L. Kastner examines in his Inflammasome study include Acquired immune system, Cancer research and Cell biology. His research investigates the connection between Rheumatoid arthritis and topics such as Arthritis that intersect with problems in PTPN22.

His most cited work include:

  • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. (1299 citations)
  • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases (1061 citations)
  • GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES (1030 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Immunology, Genetics, Familial Mediterranean fever, Internal medicine and Gene. Immunology is closely attributed to Disease in his study. His is involved in several facets of Genetics study, as is seen by his studies on Haplotype, Single-nucleotide polymorphism, Allele, Genotype and Locus.

In his work, NALP3, Signal transducing adaptor protein and Mutation is strongly intertwined with Pyrin domain, which is a subfield of Familial Mediterranean fever. The study incorporates disciplines such as Gastroenterology and Endocrinology in addition to Internal medicine. Daniel L. Kastner combines subjects such as Cancer research and Cell biology with his study of Inflammasome.

He most often published in these fields:

  • Immunology (43.75%)
  • Genetics (31.99%)
  • Familial Mediterranean fever (19.85%)

What were the highlights of his more recent work (between 2017-2021)?

  • Immunology (43.75%)
  • Cell biology (10.29%)
  • Genetics (31.99%)

In recent papers he was focusing on the following fields of study:

Immunology, Cell biology, Genetics, Inflammation and Familial Mediterranean fever are his primary areas of study. His Immunology research integrates issues from Pyoderma gangrenosum and Disease. The Cell biology study combines topics in areas such as Chromatin, Ubiquitin, Degranulation and Mast cell.

His study in Cohort extends to Genetics with its themes. His work deals with themes such as Caspase 3, Neuroscience, Neurological injury and Neurodegeneration, which intersect with Inflammation. His Familial Mediterranean fever study integrates concerns from other disciplines, such as Haploinsufficiency and MEFV.

Between 2017 and 2021, his most popular works were:

  • A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease (83 citations)
  • The Pyrin Inflammasome in Health and Disease. (60 citations)
  • Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease (53 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Mutation
  • Internal medicine

Daniel L. Kastner focuses on Immunology, Inflammation, Proinflammatory cytokine, Cell biology and Tumor necrosis factor alpha. His work carried out in the field of Immunology brings together such families of science as Adenosine and Adenosine deaminase deficiency. Daniel L. Kastner interconnects Caspase 3, Programmed cell death, Caspase 8 and Kinase activity in the investigation of issues within Inflammation.

His Proinflammatory cytokine study which covers Cytokine that intersects with Exome sequencing, Immunodeficiency, Autoinflammatory Syndrome and Immunophenotyping. His Cell biology study incorporates themes from Acquired immune system, Familial Mediterranean fever, Protein oligomerization and MEFV. His Tumor necrosis factor alpha research is multidisciplinary, incorporating perspectives in Necrosis, Treatment strategy, ADENOSINE DEAMINASE 2 and Adenosine Deaminase 2 Deficiency.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

Ann B. Begovich;Victoria E H Carlton;Lee A. Honigberg;Steven J. Schrodi.
American Journal of Human Genetics (2004)

1726 Citations

GERMLINE MUTATIONS IN THE EXTRACELLULAR DOMAINS OF THE 55 KDA TNF RECEPTOR, TNFR1, DEFINE A FAMILY OF DOMINANTLY INHERITED AUTOINFLAMMATORY SYNDROMES

Michael F McDermott;Ivona Aksentijevich;Jérôme Galon;Elizabeth M McDermott.
Cell (1999)

1370 Citations

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie.
Nature Genetics (2010)

1270 Citations

STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham.
The New England Journal of Medicine (2007)

1174 Citations

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

Seth L. Masters;Anna Simon;Ivona Aksentijevich;Daniel L. Kastner.
Annual Review of Immunology (2009)

1100 Citations

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C Coll;Avril A B Robertson;Jae Jin Chae;Sarah C Higgins.
Nature Medicine (2015)

1046 Citations

TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

Robert M. Plenge;Mark Seielstad;Leonid Padyukov;Annette T. Lee.
The New England Journal of Medicine (2007)

983 Citations

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Raphaela Goldbach-Mansky;Natalie J. Dailey;Scott W. Canna;Ana Gelabert.
The New England Journal of Medicine (2006)

911 Citations

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Ivona Aksentijevich;Miroslawa Nowak;Mustapha Mallah;Jae Jin Chae.
Arthritis & Rheumatism (2002)

870 Citations

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey.
The New England Journal of Medicine (2009)

826 Citations

If you think any of the details on this page are incorrect, let us know.

Contact us

Best Scientists Citing Daniel L. Kastner

Seza Ozen

Seza Ozen

Hacettepe University

Publications: 131

Peter K. Gregersen

Peter K. Gregersen

Feinstein Institute for Medical Research

Publications: 126

Marco Gattorno

Marco Gattorno

Istituto Giannina Gaslini

Publications: 105

Lars Klareskog

Lars Klareskog

Karolinska Institute

Publications: 103

Leonid Padyukov

Leonid Padyukov

Karolinska University Hospital

Publications: 102

Constantine A. Stratakis

Constantine A. Stratakis

National Institutes of Health

Publications: 98

Jane Worthington

Jane Worthington

Manchester Academic Health Science Centre

Publications: 97

Robert M. Plenge

Robert M. Plenge

Bristol Myers Squibb

Publications: 96

Javier Martín

Javier Martín

Spanish National Research Council

Publications: 89

Marta E. Alarcón-Riquelme

Marta E. Alarcón-Riquelme

University of Granada

Publications: 89

Michael F. McDermott

Michael F. McDermott

University of Leeds

Publications: 87

Anne Barton

Anne Barton

University of Manchester

Publications: 85

Charles A. Dinarello

Charles A. Dinarello

University of Colorado Denver

Publications: 82

Helen J. Lachmann

Helen J. Lachmann

University College London

Publications: 81

Hal M. Hoffman

Hal M. Hoffman

University of California, San Diego

Publications: 81

Lars Alfredsson

Lars Alfredsson

Karolinska Institute

Publications: 80

Something went wrong. Please try again later.