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Nick R. Leslie

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
12732
World Ranking
14317
National Ranking
1122

Nick R. Leslie publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Nick R. Leslie sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 122 publications — 13th percentile

13% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Nick R. Leslie D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Nick R. Leslie sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 56 D-Index — 28th percentile

28% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Nick R. Leslie mainly investigates PTEN, Cancer research, Protein kinase B, Phosphatase and Cell biology. He is interested in Tensin, which is a branch of PTEN. Nick R. Leslie studied Cancer research and Lipid phosphatase activity that intersect with Loss function, microRNA and Gene dosage.

His Protein kinase B study integrates concerns from other disciplines, such as Oxidative stress, Protein kinase A, Carcinogenesis, Molecular biology and PI3K/AKT/mTOR pathway. The Phosphatase study combines topics in areas such as Suppressor and C2 domain. His Cell biology research focuses on Signal transduction in particular.

His most cited work include:

  • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. (931 citations)
  • Redox regulation of PI 3-kinase signalling via inactivation of PTEN (488 citations)
  • PTEN function: how normal cells control it and tumour cells lose it (362 citations)

What are the main themes of his work throughout his whole career to date?

Nick R. Leslie spends much of his time researching PTEN, Cell biology, Cancer research, Phosphatase and Protein kinase B. His studies deal with areas such as Suppressor and Phosphorylation as well as PTEN. He has included themes like Stromal cell and Growth factor in his Cell biology study.

Nick R. Leslie usually deals with Cancer research and limits it to topics linked to Mutant and Breast cancer. As a part of the same scientific family, Nick R. Leslie mostly works in the field of Phosphatase, focusing on Protein tyrosine phosphatase and, on occasion, Reactive oxygen species. Nick R. Leslie has researched Protein kinase B in several fields, including Protein phosphatase 2, Protein kinase A, Carcinogenesis, Molecular biology and Macrocephaly.

He most often published in these fields:

  • PTEN (66.67%)
  • Cell biology (44.44%)
  • Cancer research (42.59%)

What were the highlights of his more recent work (between 2013-2020)?

  • PTEN (66.67%)
  • Cancer research (42.59%)
  • PI3K/AKT/mTOR pathway (26.85%)

In recent papers he was focusing on the following fields of study:

Nick R. Leslie mostly deals with PTEN, Cancer research, PI3K/AKT/mTOR pathway, Protein kinase B and Cell biology. His PTEN research is multidisciplinary, incorporating elements of Suppressor, Mutant, Phosphoinositide 3-kinase and Phosphatase. The various areas that Nick R. Leslie examines in his Cancer research study include Macrocephaly, Cancer, Genetics and Mutation, Germline mutation.

His research in PI3K/AKT/mTOR pathway intersects with topics in Phenotype, Loss function, Germline and Regulator. His study focuses on the intersection of Protein kinase B and fields such as Protein kinase A with connections in the field of Drug resistance, Melanoma, Receptor and MAPK/ERK pathway. His study in Cell biology is interdisciplinary in nature, drawing from both Transcriptional regulation, Glioma and Monocyte.

Between 2013 and 2020, his most popular works were:

  • Three-dimensional bioprinting of complex cell laden alginate hydrogel structures (170 citations)
  • GSK3 and its interactions with the PI3K/AKT/mTOR signalling network (146 citations)
  • Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. (128 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Nick R. Leslie mostly deals with PTEN, Cancer research, Protein kinase B, PI3K/AKT/mTOR pathway and Germline mutation. His PTEN research is under the purview of Biochemistry. Nick R. Leslie interconnects Phosphatase, Glutathione, Protein tyrosine phosphatase, Enzyme and Suppressor in the investigation of issues within Cancer research.

His work carried out in the field of PI3K/AKT/mTOR pathway brings together such families of science as Loss function and Protein kinase A, Phosphorylation. His Phosphorylation study is concerned with Cell biology in general. His biological study spans a wide range of topics, including Molecular genetics, Allele and Macrocephaly.

Best Publications

  • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

    Laura S Harrington;Greg M Findlay;Alexander Gray;Tatiana Tolkacheva

  • Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Nick R Leslie;Deborah Bennett;Yvonne E Lindsay;Hazel Stewart

  • PTEN function: how normal cells control it and tumour cells lose it

    Nick R Leslie;C Peter Downes

  • PTEN: The down side of PI 3-kinase signalling.

    Nick R. Leslie;C.Peter Downes

  • PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability.

    Ana Silva;J. Andrés Yunes;Bruno A. Cardoso;Leila R. Martins

  • Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

    Juxiang Cao;Jennifer Schulte;Alexander Knight;Nicholas R Leslie

  • GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

    Miguel A. Hermida;J. Dinesh Kumar;Nicholas R. Leslie

  • Three-dimensional bioprinting of complex cell laden alginate hydrogel structures

    Atabak Ghanizadeh Tabriz;Miguel A Hermida;Nicholas R Leslie;Winemiao Shu

  • Mechanisms of PTEN loss in cancer: it’s all about diversity

    Virginia Álvarez-Garcia;Yasmine Tawil;Helen M. Wise;Nicholas R. Leslie

  • Understanding PTEN regulation: PIP2, polarity and protein stability.

    N R Leslie;I H Batty;H Maccario;L Davidson

  • Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

    Simon A. Hawley;Fiona A. Ross;Graeme J. Gowans;Priyanka Tibarewal

  • 3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat.

    Andrew McCormack;Christopher B. Highley;Nicholas R. Leslie;Ferry P.W. Melchels

  • Small Molecule Antagonists of the σ-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo

    Barbara A Spruce;Lorna A Campbell;Niall McTavish;Michelle A Cooper

  • PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration

    Nick R. Leslie;Xuesong Yang;C. Peter Downes;Cornelis J. Weijer

  • PTEN is destabilized by phosphorylation on Thr366.

    Helene Maccario;Nevin M. Perera;Lindsay Davidson;C. Peter Downes

  • Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

    Linda S. Steelman;Patrick M. Navolanic;Melissa L. Sokolosky;Jackson R. Taylor

  • The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

    Steven M Walker;Nick R Leslie;Nevin M Perera;Ian H Batty

  • The redox regulation of PI 3-kinase-dependent signaling.

    Nick R Leslie

  • Prostate cancer, PI3K, PTEN and prognosis.

    Helen M. Wise;Miguel A. Hermida;Nicholas R. Leslie

  • Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensedoesnot permit commercial exploitation or the creation of derivative works without specific permission.

    Juxiang Cao;Jennifer Schulte;Alexander Knight;Nicholas R Leslie

Frequent Co-Authors

C. Peter Downes
C. Peter Downes University of Dundee
Dario R. Alessi
Dario R. Alessi University of Dundee
David J. Sherratt
David J. Sherratt University of Oxford
Cornelis J. Weijer
Cornelis J. Weijer University of Dundee
Alan R. Prescott
Alan R. Prescott University of Dundee
Mathias Lösche
Mathias Lösche Carnegie Mellon University
Jeremy J. Lambert
Jeremy J. Lambert University of Dundee
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Yefim Manevich
Yefim Manevich Medical University of South Carolina
Wolfram Ostertag
Wolfram Ostertag Universität Hamburg

External Links

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Best Scientists Citing Nick R. Leslie

James A. McCubrey

James A. McCubrey

East Carolina University

Publications: 77

Alberto M. Martelli

Alberto M. Martelli

University of Bologna

Publications: 54

David J. Sherratt

David J. Sherratt

University of Oxford

Publications: 40

Lucio Cocco

Lucio Cocco

University of Bologna

Publications: 35

Pier Paolo Pandolfi

Pier Paolo Pandolfi

Beth Israel Deaconess Medical Center

Publications: 34

Massimo Libra

Massimo Libra

University of Catania

Publications: 32

Dario R. Alessi

Dario R. Alessi

University of Dundee

Publications: 31

Gordon B. Mills

Gordon B. Mills

Oregon Health & Science University

Publications: 25

Brendan D. Manning

Brendan D. Manning

Harvard University

Publications: 24

Charis Eng

Charis Eng

Cleveland Clinic Lerner College of Medicine

Publications: 24

Goutam Ghosh Choudhury

Goutam Ghosh Choudhury

The University of Texas Health Science Center at San Antonio

Publications: 23

Benoit Viollet

Benoit Viollet

Institut Cochin

Publications: 21

Christophe Erneux

Christophe Erneux

Université Libre de Bruxelles

Publications: 21

Ken Inoki

Ken Inoki

University of Michigan–Ann Arbor

Publications: 20

Ramon Parsons

Ramon Parsons

Icahn School of Medicine at Mount Sinai

Publications: 19

Bart Vanhaesebroeck

Bart Vanhaesebroeck

University College London

Publications: 17

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