Nick R. Leslie

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• Cancer

Nick R. Leslie mainly investigates PTEN, Cancer research, Protein kinase B, Phosphatase and Cell biology. He is interested in Tensin, which is a branch of PTEN. Nick R. Leslie studied Cancer research and Lipid phosphatase activity that intersect with Loss function, microRNA and Gene dosage.

His Protein kinase B study integrates concerns from other disciplines, such as Oxidative stress, Protein kinase A, Carcinogenesis, Molecular biology and PI3K/AKT/mTOR pathway. The Phosphatase study combines topics in areas such as Suppressor and C2 domain. His Cell biology research focuses on Signal transduction in particular.

His most cited work include:

• The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. (931 citations)
• Redox regulation of PI 3-kinase signalling via inactivation of PTEN (488 citations)
• PTEN function: how normal cells control it and tumour cells lose it (362 citations)

What are the main themes of his work throughout his whole career to date?

Nick R. Leslie spends much of his time researching PTEN, Cell biology, Cancer research, Phosphatase and Protein kinase B. His studies deal with areas such as Suppressor and Phosphorylation as well as PTEN. He has included themes like Stromal cell and Growth factor in his Cell biology study.

Nick R. Leslie usually deals with Cancer research and limits it to topics linked to Mutant and Breast cancer. As a part of the same scientific family, Nick R. Leslie mostly works in the field of Phosphatase, focusing on Protein tyrosine phosphatase and, on occasion, Reactive oxygen species. Nick R. Leslie has researched Protein kinase B in several fields, including Protein phosphatase 2, Protein kinase A, Carcinogenesis, Molecular biology and Macrocephaly.

He most often published in these fields:

• PTEN (66.67%)
• Cell biology (44.44%)
• Cancer research (42.59%)

What were the highlights of his more recent work (between 2013-2020)?

• PTEN (66.67%)
• Cancer research (42.59%)
• PI3K/AKT/mTOR pathway (26.85%)

In recent papers he was focusing on the following fields of study:

Nick R. Leslie mostly deals with PTEN, Cancer research, PI3K/AKT/mTOR pathway, Protein kinase B and Cell biology. His PTEN research is multidisciplinary, incorporating elements of Suppressor, Mutant, Phosphoinositide 3-kinase and Phosphatase. The various areas that Nick R. Leslie examines in his Cancer research study include Macrocephaly, Cancer, Genetics and Mutation, Germline mutation.

His research in PI3K/AKT/mTOR pathway intersects with topics in Phenotype, Loss function, Germline and Regulator. His study focuses on the intersection of Protein kinase B and fields such as Protein kinase A with connections in the field of Drug resistance, Melanoma, Receptor and MAPK/ERK pathway. His study in Cell biology is interdisciplinary in nature, drawing from both Transcriptional regulation, Glioma and Monocyte.

Between 2013 and 2020, his most popular works were:

• Three-dimensional bioprinting of complex cell laden alginate hydrogel structures (170 citations)
• GSK3 and its interactions with the PI3K/AKT/mTOR signalling network (146 citations)
• Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells. (128 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• Cancer

Nick R. Leslie mostly deals with PTEN, Cancer research, Protein kinase B, PI3K/AKT/mTOR pathway and Germline mutation. His PTEN research is under the purview of Biochemistry. Nick R. Leslie interconnects Phosphatase, Glutathione, Protein tyrosine phosphatase, Enzyme and Suppressor in the investigation of issues within Cancer research.

His work carried out in the field of PI3K/AKT/mTOR pathway brings together such families of science as Loss function and Protein kinase A, Phosphorylation. His Phosphorylation study is concerned with Cell biology in general. His biological study spans a wide range of topics, including Molecular genetics, Allele and Macrocephaly.