Brendan D. Manning

Overview

Best Publications

• AKT/PKB signaling: navigating downstream.

  Brendan D. Manning;Lewis C. Cantley

  7218
  Citations

• AKT/PKB Signaling: Navigating the Network

  Brendan D. Manning;Alex Toker

  3104
  Citations

• Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

  Katrin Düvel;Jessica L. Yecies;Suchithra Menon;Pichai Raman

  2171
  Citations

• Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

  Brendan D Manning;Brendan D Manning;Andrew R Tee;M.Nicole Logsdon;John Blenis

  1905
  Citations

• Targeting the PI3K-Akt pathway in human cancer : Rationale and promise

  Ji Luo;Brendan D. Manning;Lewis C. Cantley

  1672
  Citations

• Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

  James Brugarolas;Kui Lei;Rebecca L. Hurley;Brendan D. Manning

  1670
  Citations

• Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

  Andrew R Tee;Brendan D Manning;Brendan D Manning;Philippe P Roux;Lewis C Cantley;Lewis C Cantley

  1479
  Citations

• The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

  Gerta Hoxhaj;Brendan D. Manning

  1438
  Citations

• The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

  Jingxiang Huang;Brendan D. Manning

  1422
  Citations

• The LKB1 tumor suppressor negatively regulates mTOR signaling

  Reuben J Shaw;Nabeel Bardeesy;Brendan D Manning;Lyle Lopez

  1258
  Citations

• Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

  Andrew R. Tee;Diane C. Fingar;Brendan D. Manning;David J. Kwiatkowski

  1028
  Citations

• A complex interplay between Akt, TSC2 and the two mTOR complexes

  Jingxiang Huang;Brendan D. Manning

  852
  Citations

• Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

  Suchithra Menon;Christian C. Dibble;George Talbott;Gerta Hoxhaj

  816
  Citations

• Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

  William E. Dowdle;Beat Nyfeler;Jane Nagel;Robert A. Elling

  783
  Citations

• Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

  Christian C. Dibble;Brendan D. Manning

  774
  Citations

• Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

  Issam Ben-Sahra;Jessica J. Howell;John M. Asara;Brendan D. Manning

  752
  Citations

• mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

  Issam Ben-Sahra;Gerta Hoxhaj;Stéphane J. H. Ricoult;John M. Asara

  745
  Citations

• TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

  Christian C. Dibble;Winfried Elis;Suchithra Menon;Wei Qin;Wei Qin

  663
  Citations

• Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

  Jessica L. Yecies;Hui H. Zhang;Suchithra Menon;Sihao Liu

  657
  Citations

• The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

  Jingxiang Huang;Christian C. Dibble;Mika Matsuzaki;Brendan D. Manning

  627
  Citations