2026 Lewis C. Cantley: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	233	83	77	61	57	949	245872
Molecular Biology	234	8	6	5	4	803	247477

Research.com Recognitions

2026 - Research.com Molecular Biology in United States Leader Award
2025 - Research.com Best Scientists Award
2025 - Research.com Molecular Biology in United States Leader Award
2024 - Research.com Genetics and Molecular Biology in United States Leader Award
2023 - Research.com Molecular Biology in United States Leader Award
2022 - Research.com Genetics and Molecular Biology in United States Leader Award
2019 - Louisa Gross Horwitz Prize, Columbia University
2019 - Fellow, National Academy of Inventors
2015 - Canada Gairdner International Award
2014 - Member of the National Academy of Medicine (NAM)
2013 - Breakthrough Prize in Life Sciences for the discovery of PI 3-Kinase and its role in cancer metabolism.
2011 - Robert J. and Claire Pasarow Foundation Medical Research Award
2010 - Fellow of the American Association for the Advancement of Science (AAAS)
2001 - Member of the National Academy of Sciences
1999 - Fellow of the American Academy of Arts and Sciences

Overview

Lewis C. Cantley is affiliated with Cornell University in the United States. Their research spans multiple fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

Their work engages deeply with subfields such as Molecular Biology, Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Cell Biology. Central topics in their research include:

Cancer, Hypoxia, and Metabolism
Cancer Genomics and Diagnostics
PI3K/AKT/mTOR signaling in cancer
Metabolism, Diabetes, and Cancer
RNA modifications and cancer
Pancreatic and Hepatic Oncology Research
Genetic factors in colorectal cancer

Lewis C. Cantley has authored numerous scientific papers, with recent notable publications as follows:

"An atlas of substrate specificities for the human serine/threonine kinome," 2023, Nature
"Identification of SARS-CoV-2 inhibitors using lung and colonic organoids," 2020, Nature
"Fatty acid synthesis is required for breast cancer brain metastasis," 2021, Nature Cancer
"Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition," 2020, Cancer Discovery
"The carbohydrate-insulin model: a physiological perspective on the obesity pandemic," 2021, American Journal of Clinical Nutrition

Frequent coauthors in Lewis C. Cantley's body of work include:

Jared L. Johnson
Tomer M. Yaron
Emily M. Huntsman
John Blenis
Olivier Elemento

Their publications are often found in leading journals and venues such as:

bioRxiv (Cold Spring Harbor Laboratory)
Cancer Research
Nature
Cancer Discovery
Cell

Over the course of their career, Lewis C. Cantley has been the recipient of various awards, including:

Louisa Gross Horwitz Prize, Columbia University, 2019
Fellow, National Academy of Inventors, 2019
Canada Gairdner International Award, 2015
Member of the National Academy of Medicine (NAM), 2014
Breakthrough Prize in Life Sciences, 2013, for the discovery of PI 3-Kinase and its role in cancer metabolism
Robert J. and Claire Pasarow Foundation Medical Research Award, 2011
Fellow of the American Association for the Advancement of Science (AAAS), 2010
Member of the National Academy of Sciences, 2001
Fellow of the American Academy of Arts and Sciences, 1999

Best Publications

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden;Lewis C. Cantley;Craig B. Thompson

16441
Citations
AKT/PKB signaling: navigating downstream.

Brendan D. Manning;Lewis C. Cantley

7218
Citations
The phosphoinositide 3-kinase pathway.

Lewis C. Cantley

7209
Citations
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Jeffrey A. Engelman;Kreshnik Zejnullahu;Tetsuya Mitsudomi;Youngchul Song

5364
Citations
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang;David W. White;Stefan Gross;Bryson D. Bennett

4456
Citations
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Jeffrey A. Engelman;Ji Luo;Lewis C. Cantley

3892
Citations
SH2 domains recognize specific phosphopeptide sequences

Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish

3551
Citations
Oncogenes and signal transduction

Lewis C Cantley;Kurt R Auger;Christopher Carpenter;Brian Duckworth

3505
Citations
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk;Matthew G. Vander Heiden;Marian H. Harris;Arvind Ramanathan

3183
Citations
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

Lewis C. Cantley;Benjamin G. Neel

2709
Citations
Ras, PI(3)K and mTOR signalling controls tumour cell growth.

Reuben J. Shaw;Lewis C. Cantley

2564
Citations
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw;Reuben J. Shaw;Katja A. Lamia;Debbie Vasquez;Seung Hoi Koo;Seung Hoi Koo

2318
Citations
PI3K pathway alterations in cancer: variations on a theme

TL Yuan;LC Cantley

2314
Citations
PI3K: Downstream AKTion Blocks Apoptosis

Thomas F Franke;David R Kaplan;Lewis C Cantley

2167
Citations
The PI3K pathway in human disease

David A. Fruman;Honyin Chiu;Benjamin D. Hopkins;Shubha Bagrodia

2141
Citations
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Reuben J. Shaw;Monica Kosmatka;Nabeel Bardeesy;Rebecca L. Hurley

2089
Citations
The structural basis for 14-3-3:phosphopeptide binding specificity.

Michael B Yaffe;Katrin Rittinger;Stefano Volinia;Paul R Caron

1998
Citations
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

Thomas F. Franke;David R. Kaplan;Lewis C. Cantley;Alex Toker

1995
Citations
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

John C. Obenauer;Lewis C. Cantley;Michael B. Yaffe

1976
Citations
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Haoqiang Ying;Alec C. Kimmelman;Costas A. Lyssiotis;Sujun Hua

1975
Citations

Frequent Co-Authors

John M. Asara Beth Israel Deaconess Medical Center

Matthew G. Vander Heiden MIT

Costas A. Lyssiotis University of Michigan–Ann Arbor

Jason W. Locasale Duke University

David A. Fruman University of California, Irvine

Stephen P. Soltoff Beth Israel Deaconess Medical Center

Gerburg M. Wulf Beth Israel Deaconess Medical Center

Michael B. Yaffe MIT

Jeffrey A. Engelman Novartis Institutes for BioMedical Research (NIBR)

Atsuo T. Sasaki University of Cincinnati

External Links

Wikipedia of Lewis C. Cantley Personal website of Lewis C. Cantley

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