D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Genetics and Molecular Biology
USA
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 188 Citations 140,170 461 World Ranking 13 National Ranking 9
Best Scientists D-index 236 Citations 235,570 847 World Ranking 53 National Ranking 38

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2022 - Research.com Genetics and Molecular Biology in United States Leader Award

2019 - Fellow, National Academy of Inventors

2019 - Louisa Gross Horwitz Prize, Columbia University

2015 - Canada Gairdner International Award

2014 - Member of the National Academy of Medicine (NAM)

2013 - Breakthrough Prize in Life Sciences for the discovery of PI 3-Kinase and its role in cancer metabolism.

2011 - Robert J. and Claire Pasarow Foundation Medical Research Award

2010 - Fellow of the American Association for the Advancement of Science (AAAS)

2001 - Member of the National Academy of Sciences

1999 - Fellow of the American Academy of Arts and Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Lewis C. Cantley mainly focuses on Biochemistry, Cell biology, Signal transduction, PI3K/AKT/mTOR pathway and Cancer research. His studies examine the connections between Biochemistry and genetics, as well as such issues in Cancer cell, with regards to Metabolic pathway. The various areas that Lewis C. Cantley examines in his Cell biology study include Receptor and Cell growth.

The concepts of his Signal transduction study are interwoven with issues in Regulation of gene expression and Immunology. The study incorporates disciplines such as Protein kinase B and Protein kinase A in addition to PI3K/AKT/mTOR pathway. The Cancer research study combines topics in areas such as Cancer, Mutant, KRAS, TSC2 and PTEN.

His most cited work include:

  • Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation (8625 citations)
  • The phosphoinositide 3-kinase pathway. (4510 citations)
  • AKT/PKB signaling: navigating downstream. (4442 citations)

What are the main themes of his work throughout his whole career to date?

Lewis C. Cantley mostly deals with Cell biology, Biochemistry, Cancer research, Kinase and Signal transduction. As part of his studies on Cell biology, Lewis C. Cantley frequently links adjacent subjects like Cell growth. His study looks at the relationship between Biochemistry and topics such as Cancer cell, which overlap with Metabolism.

His studies in Cancer research integrate themes in fields like Cancer, Breast cancer, KRAS, Receptor tyrosine kinase and PI3K/AKT/mTOR pathway. Lewis C. Cantley combines subjects such as Carcinogenesis and Protein kinase B with his study of PI3K/AKT/mTOR pathway. His research on Kinase frequently links to adjacent areas such as Molecular biology.

He most often published in these fields:

  • Cell biology (45.69%)
  • Biochemistry (39.84%)
  • Cancer research (27.32%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cancer research (27.32%)
  • PI3K/AKT/mTOR pathway (20.32%)
  • Cancer (15.15%)

In recent papers he was focusing on the following fields of study:

Lewis C. Cantley spends much of his time researching Cancer research, PI3K/AKT/mTOR pathway, Cancer, Cell biology and Kinase. The various areas that he examines in his Cancer research study include Metastasis, Brain metastasis, Cancer cell, Carcinogenesis and Breast cancer. His Cancer cell study combines topics in areas such as Cell culture, Biochemistry, Pancreatic cancer and Metabolic pathway.

The concepts of his PI3K/AKT/mTOR pathway study are interwoven with issues in Insulin receptor, Protein kinase B and Insulin. His Cell biology research integrates issues from Cell cycle and Downregulation and upregulation. His Kinase research includes elements of TFEB and Phosphorylation.

Between 2015 and 2021, his most popular works were:

  • The PI3K Pathway in Human Disease (672 citations)
  • Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion (472 citations)
  • Chromosomal instability drives metastasis through a cytosolic DNA response. (398 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His primary areas of investigation include Cancer research, Cancer, PI3K/AKT/mTOR pathway, Cancer cell and Cell biology. His work carried out in the field of Cancer research brings together such families of science as Cell growth, Interferon, Mitosis, Crosstalk and Metastasis. The Cancer study combines topics in areas such as Exome sequencing and Bioinformatics.

PI3K/AKT/mTOR pathway is a subfield of Signal transduction that Lewis C. Cantley investigates. His research integrates issues of Pancreatic cancer, Carcinogenesis, Biochemistry, Alanine and Lipid biosynthesis in his study of Cancer cell. The study incorporates disciplines such as Fructose-bisphosphate aldolase and Actin cytoskeleton in addition to Cell biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden;Lewis C. Cantley;Craig B. Thompson.
Science (2009)

11684 Citations

The phosphoinositide 3-kinase pathway.

Lewis C. Cantley.
Science (2002)

6526 Citations

AKT/PKB signaling: navigating downstream.

Brendan D. Manning;Lewis C. Cantley.
Cell (2007)

6211 Citations

MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

Jeffrey A. Engelman;Kreshnik Zejnullahu;Tetsuya Mitsudomi;Youngchul Song.
Science (2007)

4811 Citations

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang;David W. White;Stefan Gross;Bryson D. Bennett.
Nature (2009)

3442 Citations

Oncogenes and signal transduction

Lewis C Cantley;Kurt R Auger;Christopher Carpenter;Brian Duckworth.
Cell (1991)

3416 Citations

SH2 domains recognize specific phosphopeptide sequences

Songyang Zhou;Songyang Zhou;Steven E. Shoelson;Manas Chaudhuri;Gerald Gish.
Cell (1993)

3413 Citations

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Jeffrey A. Engelman;Ji Luo;Lewis C. Cantley.
Nature Reviews Genetics (2006)

3251 Citations

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk;Matthew G. Vander Heiden;Marian H. Harris;Arvind Ramanathan.
Nature (2008)

2640 Citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

Lewis C. Cantley;Benjamin G. Neel.
Proceedings of the National Academy of Sciences of the United States of America (1999)

2599 Citations

Editorial Boards

Cancer Discovery
(Impact Factor: 38.272)

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