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Roger F. Butterworth

Roger F. Butterworth

D-Index & Metrics

Medicine

D-Index
95
Citations
28027
World Ranking
10180
National Ranking
406

Overview

Roger F. Butterworth is affiliated with the University of Montreal in Canada and has contributed to medical research primarily in the field of Medicine, with a focus on Infectious Diseases, Neurology, Hepatology, Epidemiology, and Cardiology and Cardiovascular Medicine.

Their work covers a range of topics, notably:

  • Long-Term Effects of COVID-19
  • COVID-19 Clinical Research Studies
  • Liver Disease and Transplantation
  • Liver Disease Diagnosis and Treatment
  • Infectious Encephalopathies and Encephalitis
  • Cardiac, Anesthesia and Surgical Outcomes
  • Respiratory Support and Mechanisms

Roger F. Butterworth has published research primarily in the following venues:

  • Journal of Pharmaceutics & Pharmacology (3 publications)
  • Drugs in R&D (2 publications)
  • Frontiers in Neuroscience (1 publication)
  • Metabolic Brain Disease (1 publication)
  • International Journal of Obstetric Anesthesia (1 publication)

Frequent coauthors collaborating with Butterworth include:

  • Vorakamol Phoophiboon
  • Antenor Rodrigues
  • Matthew Ko
  • Mayson Laércio de Araújo Sousa
  • Annia Schreiber

Selected recent papers highlight the range and focus of their research. These include:

  • "Potential for the Repurposing of Adamantane Antivirals for COVID-19," 2021, published in Drugs in R&D
  • "Ammonia Removal by Metabolic Scavengers for the Prevention and Treatment of Hepatic Encephalopathy in Cirrhosis," 2021, published in Drugs in R&D
  • "Adamantanes for the treatment of neurodegenerative diseases in the presence of SARS-CoV-2," 2023, published in Frontiers in Neuroscience
  • "Region-selective permeability of the blood-brain barrier to α-aminoisobutyric acid during thiamine deficiency and following its reversal," 2020, published in Metabolic Brain Disease
  • "Potential for the Repurposing of Adamantanes for the Treatment of Covid-19," 2020, published in Journal of Pharmaceutics & Pharmacology

The research consistently addresses neurological and infectious diseases in the context of the COVID-19 pandemic, as well as liver-related disorders such as hepatic encephalopathy. Investigations into mechanisms such as blood-brain barrier permeability and antiviral repurposing are recurrent themes in Butterworth's work.

Best Publications

  • Neurobiology of ammonia

    Vicente Felipo;Roger F. Butterworth

  • Ammonia: key factor in the pathogenesis of hepatic encephalopathy.

    Roger F. Butterworth;Jean-François Giguère;Jean Michaud;Joël Lavoie

  • The nutritional management of hepatic encephalopathy in patients with cirrhosis: International society for hepatic encephalopathy and nitrogen metabolism consensus

    Piero Amodio;Chantal Bemeur;Roger Butterworth;Juan Cordoba

  • Pathophysiology of hepatic encephalopathy: a new look at ammonia.

    Roger F. Butterworth

  • Review article: the design of clinical trials in hepatic encephalopathy - an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement

    J. S. Bajaj;J. Cordoba;Kevin D Mullen;P. Amodio

  • Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats.

    Margaret Swain;Roger F. Butterworth;Andres T. Blei

  • Hepatic encephalopathy: An update of pathophysiologic mechanisms.

    Alan S. Hazell;Roger F. Butterworth

  • Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

    L Spahr;R F Butterworth;S Fontaine;L Bui

  • Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis

    Andres T. Blei;Sigurdur Olafsson;Guy Therrien;Roger F. Butterworth

  • Experimental models of hepatic encephalopathy: ISHEN guidelines.

    Roger F. Butterworth;Michael D. Norenberg;Vicente Felipo;Peter Ferenci

  • Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

    Christopher F. Rose;Roger F. Butterworth;Joseph Zayed;Louise Normandin

  • Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes.

    Freimut Schliess;Boris Görg;Richard Fischer;Paul Desjardins

  • Selective increase of brain lactate synthesis in experimental acute liver failure: Results of a [1H-13C] nuclear magnetic resonance study

    Claudia Zwingmann;Nicolas Chatauret;Dieter Leibfritz;Roger F. Butterworth

  • Complications of cirrhosis III. Hepatic encephalopathy

    Roger F. Butterworth

  • Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.

    Joël Lavoie;Jean-Francois Giguère;Gilles Pomier Layrargues;Roger F. Butterworth

  • Hepatic encephalopathy: a central neuroinflammatory disorder?

    Roger F. Butterworth

  • Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome.

    Roger F. Butterworth;Jillian J. Kril;Clive G. Harper

  • Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy

    Roger F. Butterworth;Laurent Spahr;Suzanne Fontaine;Gilles Pomier Layrargues

  • Effect of ammonium ions on synaptic transmission in the mammalian central nervous system.

    John C. Szerb;Roger F. Butterworth

  • Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

    Roger F. Butterworth;Anne Marie Besnard

Frequent Co-Authors

Alan S. Hazell
Alan S. Hazell University of Montreal
Glen B. Baker
Glen B. Baker University of Alberta
Dieter Leibfritz
Dieter Leibfritz University of Bremen
Andres T. Blei
Andres T. Blei Northwestern University
Edith Hamel
Edith Hamel Montreal Neurological Institute and Hospital
Vicente Felipo
Vicente Felipo Centro de Investigacion Principe Felipe
Peter R. Dodd
Peter R. Dodd University of Queensland
Stephen Hanessian
Stephen Hanessian University of Montreal
Tomás A. Reader
Tomás A. Reader University of Montreal
Jillian J. Kril
Jillian J. Kril University of Sydney

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