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Stephen Hanessian

Stephen Hanessian

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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
87
Citations
28372
World Ranking
2399
National Ranking
50

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award
  • 1997 - Izaak Walton Killam Memorial Prize, Canada Council
  • 1996 - Prix Marie-Victorin, Government of Quebec
  • 1988 - Fellow of the Royal Society of Canada Academy of Science
  • 1988 - Chemical Institute of Canada Medal

Overview

Stephen Hanessian is affiliated with the University of Montreal in Canada. Their research primarily spans the fields of Materials Science, Chemistry, and Biochemistry, Genetics and Molecular Biology. Within these broad disciplines, their work focuses on subfields such as Materials Chemistry, Organic Chemistry, and Molecular Biology, with smaller contributions in Physiology and Physical and Theoretical Chemistry.

The scientist's research topics include:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Chemical Synthesis and Analysis
  • Asymmetric Synthesis and Catalysis
  • Advanced biosensing and bioanalysis techniques
  • Synthesis and Catalytic Reactions
  • Oxidative Organic Chemistry Reactions

They have published frequently in venues such as:

  • The Cambridge Structural Database
  • The Journal of Organic Chemistry
  • Canadian Journal of Chemistry
  • Synthesis
  • ACS Medicinal Chemistry Letters

Among recent scientific papers authored or coauthored by Stephen Hanessian are:

  • Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity (2021, EMBO Molecular Medicine)
  • Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics (2023, Nucleic Acids Research)
  • Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines (2020, ACS Medicinal Chemistry Letters)
  • Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA (2022, Journal of the American Chemical Society)
  • Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2-Functionalized Isoquinolones: Creating Diversity at C-6 and C-7 to Address Bioactive Analogues (2020, ACS Omega)

Frequent collaborators in their work include Sofiane Hocine, Gilles Berger, Jean-Baptiste Garsi, Thierry Maris, and Aaron Gabriel Nunez Avila.

Stephen Hanessian has received several awards over the course of their career, including:

  • Izaak Walton Killam Memorial Prize from the Canada Council in 1997
  • Prix Marie-Victorin granted by the Government of Quebec in 1996
  • Chemical Institute of Canada Medal in 1988
  • Fellowship of the Royal Society of Canada's Academy of Science in 1988

Best Publications

  • Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

    Stephen Hanessian;Grant McNaughton-Smith;Henry-Georges Lombart;William D. Lubell

  • Regioselective manipulation of hydroxyl groups via organotin derivatives

    S. David;S. Hanessian

  • Preparative Carbohydrate Chemistry

    Unknown

  • The Preparation and Synthetic Utility of tert-Butyldiphenylsilyl Ethers

    Stephen Hanessian;Pierre Lavallee

  • Analysis of trimethylsilyl derivatives of carbohydrates by gas chromatography and mass spectrometry

    Don C. DeJongh;T. Radford;Jeremy D. Hribar;Stephen Hanessian

  • trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition.

    Youssef L. Bennani† and;Stephen Hanessian

  • Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

    Martin Büschleb;Stéphane Dorich;Stephen Hanessian;Daniel Tao

  • Catalytic asymmetric conjugate addition of nitroalkanes to cycloalkenones.

    Stephen Hanessian;Vinh Pham

  • Chemistry of the glycosidic linkage. An efficient synthesis of 1,2-trans-di-saccharides

    Stephen Hanessian;Joseph Banoub

  • Design of Secondary Structures in Unnatural Peptides: Stable Helical γ-Tetra-, Hexa-, and Octapeptides and Consequences of α-Substitution

    Stephen Hanessian;Xuehong Luo;and Robert Schaum;Stephen Michnick

  • Synthesis of naturally occurring C-nucleosides, their analogs, and functionalized C-glycosyl precursors.

    Stephen Hanessian;André G. Pernet

  • Reaction of O-benzylidene sugars with N-bromosuccinimide. II. Scope and synthetic utility in the methyl 4,6-0-benzylidenehexopyranoside series

    Stephen Hanessian;Nike R. Plessas

  • Procedures for the direct replacement of primary hydroxyl groups in carbohydrates by halogen

    S. Hanessian;M.M. Ponpipom;P. Lavallee

  • Neuronal activity‐dependent increase of net matrix metalloproteinase activity is associated with MMP‐9 neurotoxicity after kainate

    Jérôme Jourquin;Evelyne Tremblay;Nadège Décanis;Gérard Charton

  • Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron

    Stephen Hanessian;Teresa Abad-Grillo;Grant McNaughton-Smith

  • Chemistry and biology of the aeruginosin family of serine protease inhibitors.

    Karolina Ersmark;Juan R. Del Valle;Stephen Hanessian

  • Design and reactivity of topologically unique, chiral phosphonamides. Remarkable diastereofacial selectivity in asymmetric olefination and alkylation

    Stephen Hanessian;D. Delorme;S. Beaudoin;Y. Leblanc

  • Recent Progress in the Chemistry of Daphniphyllum Alkaloids

    Amit Kumar Chattopadhyay;Stephen Hanessian

  • Stereocontrolled glycosyl transfer reactions with unprotected glycosyl donors.

    Stephen Hanessian;Boliang Lou

  • The reaction of O-benzylidene sugars with N-bromosuccinimide

    Stephen Hanessian

  • Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins.

    Crystel Ogier;Anne Bernard;Anne-Marie Chollet;Thierry Le Diguardher

Frequent Co-Authors

Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Punit P. Seth
Punit P. Seth Ionis Pharmaceuticals (United States)
Eric Westhof
Eric Westhof University of Strasbourg
Raffaele Saladino
Raffaele Saladino Tuscia University
Roger F. Butterworth
Roger F. Butterworth University of Montreal
Hing L. Sham
Hing L. Sham Global Blood Therapeutics (United States)
Peter C. Tyler
Peter C. Tyler Victoria University of Wellington
Beat Ernst
Beat Ernst University of Basel
René Roy
René Roy University of Quebec at Montreal
Larry E. Overman
Larry E. Overman University of California, Irvine

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