World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
81
Citations
25176
World Ranking
3222
National Ranking
1069

Research.com Recognitions

  • 1994 - Fellow of Alfred P. Sloan Foundation
  • 1990 - Corday–Morgan Prize, Royal Society of Chemistry (UK)

Overview

David Crich is affiliated with the University of Georgia in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and chemistry. Their research primarily focuses on carbohydrate chemistry and synthesis, glycosylation and glycoproteins research, and chemical synthesis and analysis. Additional areas of work include RNA and protein synthesis mechanisms, enzyme catalysis and immobilization, enzyme production and characterization, and antibiotic resistance in bacteria.

Crich's work spans various subfields including molecular biology, organic chemistry, infectious diseases, materials chemistry, and biotechnology. This broad interdisciplinary approach is reflected in their frequent publication venues:

  • The Journal of Organic Chemistry (9 publications)
  • Organic Letters (8 publications)
  • Journal of the American Chemical Society (7 publications)
  • Carbohydrate Research (7 publications)
  • ACS Infectious Diseases (4 publications)

Frequent collaborators of Crich include Sven N. Hobbie, Klara Haldimann, Andrea Vasella, Jarvis Hill, and Erik C. Böttger, each contributing across multiple joint publications.

Some of Crich's recent papers encompass:

  • "Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease," 2020, ACS Infectious Diseases
  • "Mechanisms of Stereodirecting Participation and Ester Migration from Near and Far in Glycosylation and Related Reactions," 2020, Chemical Reviews
  • "En Route to the Transformation of Glycoscience: A Chemist's Perspective on Internal and External Crossroads in Glycochemistry," 2020, Journal of the American Chemical Society
  • "Guidelines for O-Glycoside Formation from First Principles," 2021, ACS Central Science
  • "Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors," 2022, Angewandte Chemie International Edition

Their contributions have been recognized by awards such as the Corday-Morgan Prize from the Royal Society of Chemistry (UK) in 1990 and being named a Fellow of the Alfred P. Sloan Foundation in 1994.

Best Publications

  • Chemistry of Acyl Radicals

    Chryssostomos Chatgilialoglu;David Crich;Mitsuo Komatsu;Ilhyong Ryu

  • The invention of new radical chain reactions. Part VIII. Radical chemistry of thiohydroxamic esters; A new method for the generation of carbon radicals from carboxylic acids

    Derek H.R. Barton;David Crich;William B. Motherwell

  • Radical chemistry associated with the thiocarbonyl group

    David Crich;Leticia Quintero

  • Free Radical Chain Reactions in Organic Synthesis

    William B. Motherwell;David Crich

  • Mechanism of a Chemical Glycosylation Reaction

    David Crich

  • Chemistry of the Hexahydropyrrolo[2,3-b]indoles: configuration, conformation, reactivity, and applications in synthesis.

    David Crich;Abhisek Banerjee

  • Direct chemical synthesis of β-mannopyranosides and other glycosides via glycosyl triflates

    David Crich;Sanxing Sun

  • Direct Formation of β-Mannopyranosides and Other Hindered Glycosides from Thioglycosides

    David Crich;Sanxing Sun

  • Formation of beta-Mannopyranosides of Primary Alcohols Using the Sulfoxide Method.

    David Crich;Sanxing Sun

  • The Experimental Evidence in Support of Glycosylation Mechanisms at the SN1–SN2 Interface

    Philip Ouma Adero;Harsha Amarasekara;Peng Wen;Luis Bohé

  • Native chemical ligation at phenylalanine.

    David Crich;Abhisek Banerjee

  • Why are the hydroxy groups of partially protected N-acetylglucosamine derivatives such poor glycosyl acceptors, and what can be done about it? A comparative study of the reactivity of N-acetyl-, N-phthalimido-, and 2-azido-2-deoxy-glucosamine derivatives in glycosylation. 2-Picolinyl ethers as reactivity-enhancing replacements for benzyl ethers.

    David Crich;Vadim Dudkin

  • New and improved methods for the radical decarboxylation of acids

    Derek H. R. Barton;David Crich;William B. Motherwell

  • Mechanism of 4,6‐O‐Benzylidene‐Directed β‐Mannosylation as Determined by α‐Deuterium Kinetic Isotope Effects

    David Crich;N. Susantha Chandrasekera

  • Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.

    Brendan T. Freitas;Ian A. Durie;Jackelyn Murray;Jaron E. Longo

  • A practical alternative to the hunsdiecker reaction

    Derek H.R. Barton;David Crich;William B. Motherwell

  • Chemistry of 4,6-O-Benzylidene-d-glycopyranosyl Triflates: Contrasting Behavior between the Gluco and Manno Series

    David Crich;Weiling Cai

  • Dissecting the mechanisms of a class of chemical glycosylation using primary 13C kinetic isotope effects

    Min Huang;Graham E. Garrett;Graham E. Garrett;Nicolas Birlirakis;Luis Bohé

  • O-Sialylation with N-Acetyl-5-N,4-O-Carbonyl-Protected Thiosialoside Donors in Dichloromethane: Facile and Selective Cleavage of the Oxazolidinone Ring

    David Crich;Wenju Li

  • Mechanisms of Stereodirecting Participation and Ester Migration from Near and Far in Glycosylation and Related Reactions

    Asiri A. Hettikankanamalage;Robert Lassfolk;Filip S. Ekholm;Reko Leino

  • α-Selective Sialylations at −78 °C in Nitrile Solvents with a 1-Adamantanyl Thiosialoside

    David Crich;Wenju Li

Frequent Co-Authors

Andrea Vasella
Andrea Vasella ETH Zurich
Erik C. Böttger
Erik C. Böttger University of Zurich
William B. Motherwell
William B. Motherwell University College London
Derek H. R. Barton
Derek H. R. Barton Texas A&M University
Martin Newcomb
Martin Newcomb University of Illinois at Chicago
Mark D. Smith
Mark D. Smith University of South Carolina
Andrew D. Mesecar
Andrew D. Mesecar Purdue University West Lafayette
Donald M. Kuhn
Donald M. Kuhn Wayne State University
Jochen Schacht
Jochen Schacht University of Michigan–Ann Arbor
Fabien Kenig
Fabien Kenig University of Illinois at Chicago

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry who wish to expand their career options, exploring related fields like forensic science and criminal justice can be highly beneficial. Many universities now offer affordable programs, such as a forensic science bachelor degree online, which combines chemical knowledge with investigative techniques.

Graduate studies are also gaining popularity, with options for an online master's degree in forensic psychology providing deeper insight into the psychological aspects behind criminal behavior. These degrees can open doors to specialized roles in both science and law enforcement sectors.

High earning potential is a notable incentive—there are several high paying jobs in forensics that leverage scientific expertise in crime labs, legal consulting, or investigative analysis.

When planning your education path, it’s important to understand financial commitments. Resources like how much does a criminal justice degree cost break down typical tuition and fees, helping you make informed decisions about your investment in education.

Best Scientists Citing David Crich

Trending Scientists