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Samuel J. Danishefsky

Samuel J. Danishefsky

D-Index & Metrics

Chemistry

D-Index
125
Citations
60198
World Ranking
399
National Ranking
173

Research.com Recognitions

  • 2006 - NAS Award in Chemical Sciences, National Academy of Sciences (US) For his wide-ranging accomplishments in natural products total synthesis and for his pioneering chemical synthesis of carbohydrates for the development of anticancer vaccines.
  • 2006 - Benjamin Franklin Medal, Franklin Institute
  • 2001 - F.A. Cotton Medal for Excellence in Chemical Research, American Chemical Society (ACS)
  • 1999 - William H. Nichols Medal, American Chemical Society (ACS)
  • 1998 - Arthur C. Cope Award, American Chemical Society (ACS)
  • 1996 - Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry, Elsevier
  • 1995 - Wolf Prize in Chemistry, Wolf Foundation for designing and developing novel chemical reactions which have opened new avenues to the synthesis of complex molecules, particularly polysaccharides and many other biologically and medicinally important compounds.
  • 1986 - Member of the National Academy of Sciences
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1984 - Fellow of the American Academy of Arts and Sciences
  • 1981 - Ernest Guenther Award, American Chemical Society (ACS)

Overview

Samuel J. Danishefsky is an active researcher affiliated with Columbia University in the United States. Their work spans multiple scientific disciplines, focusing primarily on Medicine, Biochemistry, Genetics and Molecular Biology, as well as Environmental Science.

The main subfields of study include Radiology, Nuclear Medicine and Imaging, Molecular Biology, and Ecology. Their research topics prominently cover areas such as Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, and Bacteriophages and microbial interactions.

One recent publication by Samuel J. Danishefsky is titled "Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide," published in 2020 in UNC Libraries.

  • S. Munir Alam
  • Baptiste Aussedat
  • Yusuf Vohra
  • Robert Meyerhoff
  • Evan M. Cale

  • UNC Libraries

Samuel J. Danishefsky has received several awards throughout their career, including the NAS Award in Chemical Sciences by the National Academy of Sciences (US) in 2006, awarded for broad accomplishments in natural products total synthesis and pioneering chemical synthesis of carbohydrates for anticancer vaccine development.

Other awards include the Benjamin Franklin Medal from the Franklin Institute in 2006, the F.A. Cotton Medal for Excellence in Chemical Research from the American Chemical Society (ACS) in 2001, and the William H. Nichols Medal from ACS in 1999.

They were also honored with the Arthur C. Cope Award from ACS in 1998, the Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry in 1996, and the Wolf Prize in Chemistry from the Wolf Foundation in 1995, recognized for contributions in designing and developing novel chemical reactions relevant to the synthesis of complex molecules.

Additional recognitions include being a Fellow of the American Association for the Advancement of Science (AAAS) since 1986, a Member of the National Academy of Sciences since 1986, a Fellow of the American Academy of Arts and Sciences since 1984, and recipient of the Ernest Guenther Award from ACS in 1981.

Best Publications

  • The B-alkyl Suzuki-Miyaura cross-coupling reaction: Development, mechanistic study, and applications in natural product synthesis

    Sherry R. Chemler;Dirk Trauner;Samuel J. Danishefsky

  • Free‐Radical‐Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides

    Unknown

  • From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate‐Based Anticancer Vaccines

    Samuel J. Danishefsky;Jennifer R. Allen

  • Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence

    Unknown

  • Gelsemine: A Thought‐Provoking Target for Total Synthesis

    Unknown

  • On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides

    Randall L. Halcomb;Samuel J. Danishefsky

  • Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

    C Schneider;L Sepp-Lorenzino;E Nimmesgern;O Ouerfelli

  • Useful diene for the Diels-Alder reaction

    Unknown

  • Total Synthesis of Baccatin III and Taxol

    Unknown

  • Siloxy dienes in total synthesis

    Samuel Danishefsky

  • A common pharmacophore for cytotoxic natural products that stabilize microtubules

    Iwao Ojima;Subrata Chakravarty;Tadashi Inoue;Songnian Lin

  • Total Synthesis of (–)‐Epothilone A

    Aaron Balog;Dongfang Meng;Ted Kamenecka;Peter Bertinato

  • Total Syntheses of Epothilones A and B

    Dongfang Meng;Peter Bertinato;Aaron Balog;Dai Shi Su

  • Total synthesis of taxol

    Samuel J. Danishefsky;William G. Bornmann;Yves Queneau;Thomas V. Magee

  • Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man

    S. F. Slovin;G. Ragupathi;S. Adluri;G. Ungers

  • A Strategy for the Solid-Phase Synthesis of Oligosaccharides

    Unknown

  • Synthetic and Immunological Studies on Clustered Modes of Mucin-Related Tn and TF O-Linked Antigens: The Preparation of a Glycopeptide-Based Vaccine for Clinical Trials against Prostate Cancer†

    Scott D. Kuduk;Jacob B. Schwarz;Xiao-Tao Chen;Peter W. Glunz

  • The Total Synthesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug

    Matthew D. Shair;Tae Young Yoon;Karoline K. Mosny;T. C. Chou

  • REMOTE EFFECTS IN MACROLIDE FORMATION THROUGH RING-FORMING OLEFIN METATHESIS : AN APPLICATION TO THE SYNTHESIS OF FULLY ACTIVE EPOTHILONE CONGENERS

    Dongfang Meng;Dai-Shi Su;Aaron Balog;Peter Bertinato

  • Development of Globo-H Cancer Vaccine

    Samuel J. Danishefsky;Youe Kong Shue;Michael N. Chang;Chi Huey Wong;Chi Huey Wong

  • Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis.

    Jin Chen;Qian Wan;Yu Yuan;Jianglong Zhu

  • Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

    Mark M. Moasser;Laura Sepp-Lorenzino;Nancy E. Kohl;Allen Oliff

  • Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

    Dai Shi Su;Dongfang Meng;Dongfang Meng;Peter Bertinato;Aaron Balog

  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof

    Samuel J. Danishefsky;Peter Bertinato;Dai-Shi Su;Dang Fang Meng

  • Interactivity of chiral catalysts and chiral auxiliaries in the cycloaddition of activated dienes with aldehydes: a synthesis of L-glucose

    Mark. Bednarski;Samuel. Danishefsky

  • Erythropoietin derived by chemical synthesis.

    Ping Wang;Suwei Dong;Jae-Hung Shieh;Elizabeth Peguero

  • Total Synthesis of Baccatin III and Taxol

    S. J. Danishefsky;J. J. Masters;W. B. Young;J. T. Link

Frequent Co-Authors

Ting-Chao Chou
Ting-Chao Chou Memorial Sloan Kettering Cancer Center
Philip O. Livingston
Philip O. Livingston Memorial Sloan Kettering Cancer Center
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Jon T. Njardarson
Jon T. Njardarson University of Arizona
Gong Chen
Gong Chen Nankai University
Barton F. Haynes
Barton F. Haynes Duke University
Susan Band Horwitz
Susan Band Horwitz Albert Einstein College of Medicine
Erik J. Sorensen
Erik J. Sorensen Princeton University
Dalibor Sames
Dalibor Sames Columbia University

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