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D-Index & Metrics

Chemistry

D-Index
80
Citations
20401
World Ranking
3470
National Ranking
1133

Overview

Robert M. Williams was affiliated with Colorado State University in the United States. Their research spanned several fields primarily within biochemistry, genetics, and molecular biology, with extensions into medicine.

The scientist produced work across multiple subfields, including:

  • Pharmacology
  • Molecular Biology
  • Materials Chemistry
  • Biotechnology
  • Organic Chemistry

Their main research topics focused extensively on:

  • Microbial Natural Products and Biosynthesis
  • Marine Sponges and Natural Products
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Microbial Metabolism and Applications
  • Alkaloids: synthesis and pharmacology
  • Ethics and Social Impacts of AI

Among recent papers authored or coauthored by Williams were the following:

  • "Fungal-derived brevianamide assembly by a stereoselective semipinacolase," 2020, published in Nature Catalysis
  • "Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway," 2020, published in Journal of the American Chemical Society
  • "Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, Irpex lacteus and Phaeosphaeria oryzae," 2020, published in Journal of Natural Products
  • "Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides," 2020, published in ChemBioChem
  • "Understanding and Avoiding AI Failures: A Practical Guide," 2021, published by MDPI (MDPI AG)

Frequent collaborators included:

  • David H. Sherman
  • Sean A. Newmister
  • Sachiko Tsukamoto
  • Amy E. Fraley
  • Hikaru Kato

Key publication venues in their career were:

  • The Cambridge Structural Database
  • Journal of Natural Products
  • ChemBioChem
  • Nature Catalysis
  • Journal of the American Chemical Society

Best Publications

  • Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics.

    Jack D. Scott and;Robert M. Williams

  • The Asymmetric Total Synthesis of (+)- and (−)-Spirotryprostatin B

    Paul R. Sebahar and;Robert M. Williams

  • Paraherquamides, Brevianamides, and Asperparalines: Laboratory Synthesis and Biosynthesis. An Interim Report

    Unknown

  • Chemistry and Biology of Biosynthetic Diels–Alder Reactions

    Unknown

  • Asymmetric synthesis of arylglycines

    Robert M. Williams;James A. Hendrix

  • Notoamides A–D: Prenylated Indole Alkaloids Isolated from a Marine‐Derived Fungus, Aspergillus sp.

    Hikaru Kato;Takushi Yoshida;Takanori Tokue;Yuka Nojiri

  • Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal ()-Stephacidin A and (+)-Notoamide B from Aspergillus versicolor NRRL 35600**

    Thomas J. Greshock;Alan W. Grubbs;Ping Jiao;Donald T. Wicklow;Donald T. Wicklow

  • Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase

    Stefan Jennewein;Christopher D. Rithner;Robert M. Williams;Rodney B. Croteau

  • Enantiomeric natural products: occurrence and biogenesis.

    Jennifer M. Finefield;David H. Sherman;Martin Kreitman;Robert M. Williams;Robert M. Williams

  • Asymmetric synthesis of monosubstituted and .alpha.,.alpha.-disubstituted .alpha.-amino acids via diastereoselective glycine enolate alkylations

    Robert M. Williams;Myeong Nyeo Im

  • Practical asymmetric syntheses of .alpha.-amino acids through carbon-carbon bond constructions on electrophilic glycine templates

    Robert M. Williams;Peter J. Sinclair;Dongguan. Zhai;Daimo. Chen

  • Molecular cloning of a cytochrome P450 taxane 10β-hydroxylase cDNA from Taxus and functional expression in yeast

    Anne Schoendorf;Christopher D. Rithner;Robert M. Williams;Rodney B. Croteau

  • Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743

    Christopher M. Rath;Benjamin Janto;Josh Earl;Azad Ahmed

  • Cytochrome P450 Taxadiene 5α-Hydroxylase, a Mechanistically Unusual Monooxygenase Catalyzing the First Oxygenation Step of Taxol Biosynthesis

    Stefan Jennewein;Robert M. Long;Robert M. Williams;Rodney Croteau

  • Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5a-o1: the first oxygenation step in taxol biosynthesis

    Jerry Hefner;Steven M. Rubenstein;Raymond E.B. Ketchum;Donna M. Gibson

  • Biosynthesis of Prenylated Alkaloids Derived from Tryptophan

    Robert M. Williams;Emily M. Stocking;Juan F. Sanz-Cervera

  • Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

    Jennifer M. Finefield;Jens C. Frisvad;David H. Sherman;Robert M. Williams

  • Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

    Albert Bowers;Nathan West;Jack Taunton;Stuart L. Schreiber

  • Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

    Sajal K. Ghosh;Susan P. Perrine;Robert M. Williams;Douglas V. Faller

  • Asymmetric, stereocontrolled total synthesis of (-)-brevianamide B

    Robert M. Williams;Tomasz Glinka;Ewa Kwast;Hazel Coffman

  • Concise, asymmetric, stereocontrolled total synthesis of stephacidins A, B and notoamide B.

    Gerald D. Artman;and Alan W. Grubbs;Robert M. Williams

  • Stereocontrolled Total Synthesis of (+)-Paraherquamide B⊥

    Timothy D. Cushing;Juan F. Sanz-Cervera;Robert M. Williams

Frequent Co-Authors

David H. Sherman
David H. Sherman University of Michigan–Ann Arbor
Sachiko Tsukamoto
Sachiko Tsukamoto Kumamoto University
Rodney Croteau
Rodney Croteau Washington State University
Douglas V. Faller
Douglas V. Faller Takeda (Japan)
Olaf Wiest
Olaf Wiest University of Notre Dame
Oren P. Anderson
Oren P. Anderson Colorado State University
Janet L. Smith
Janet L. Smith University of Michigan–Ann Arbor
James E. Bradner
James E. Bradner Amgen (United States)
Jens Christian Frisvad
Jens Christian Frisvad Technical University of Denmark
Martin Kreitman
Martin Kreitman University of Chicago

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