World's Best Scientists 2026 revealed!

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Chemistry

D-Index
74
Citations
17219
World Ranking
4784
National Ranking
1503

Biology and Biochemistry

D-Index
79
Citations
20099
World Ranking
4368
National Ranking
2128

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Janet L. Smith is affiliated with the University of Michigan-Ann Arbor in the United States. Their scientific work spans multiple fields, including Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on molecular biology, pharmacology, public health, environmental and occupational health, immunology, and oncology at the subfield level.

Their research covers several main topics, which include microbial natural products and biosynthesis, mosquito-borne diseases and control, carbohydrate chemistry and synthesis, interferon and immune responses, enzyme structure and function, malaria research and control, and microbial metabolic engineering and bioproduction.

Recent scholarly articles authored or co-authored by Janet L. Smith highlight a diverse range of subjects. These papers include:

  • Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction (2021, Science)
  • Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands (2021, Frontiers in Immunology)
  • Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway (2020, Journal of the American Chemical Society)
  • Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2 (2020, Journal of Controlled Release)
  • Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction (2023, Proceedings of the National Academy of Sciences)

Janet L. Smith frequently collaborates with several colleagues in their research efforts. Prominent co-authors include David H. Sherman, Nagarajan Venugopalan, Stephen Corcoran, Mark Hilgart, and David J. Kissick.

Publication venues where Janet L. Smith has contributed frequently encompass:

  • Acta Crystallographica Section A Foundations and Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Structural Dynamics
  • Structure
  • Biophysical Journal

Their contributions have been recognized through awards such as becoming a Member of the National Academy of Sciences in 2020 and a Fellow of the American Association for the Advancement of Science (AAAS) in 2007.

Best Publications

  • Structure of the Cytochrome b6f Complex of Oxygenic Photosynthesis: Tuning the Cavity

    Genji Kurisu;Genji Kurisu;Huamin Zhang;Janet L. Smith;William A. Cramer

  • Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.

    W A Hendrickson;A Pähler;J L Smith;Y Satow

  • A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

    James A. Brannigan;Guy Dodson;Guy Dodson;Helen J. Duggleby;Peter C.E. Moody;Peter C.E. Moody

  • A New Generation of Crystallographic Validation Tools for the Protein Data Bank

    Randy J. Read;Paul D. Adams;W. Bryan Arendall;Axel T. Brunger

  • Structure of myohemerythrin in the azidomet state at 1.7/1.3 A resolution.

    Steven Sheriff;Wayne A. Hendrickson;Wayne A. Hendrickson;Janet L. Smith;Janet L. Smith

  • Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

    David L. Akey;W. Clay Brown;Somnath Dutta;Jamie Konwerski

  • Crystal structure of chloroplast cytochrome freveals a novel cytochrome fold and unexpected heme ligation

    Sergio E Martinez;Deru Huang;Andrzej Szczepaniak;William A Cramer

  • Structure of a modular polyketide synthase

    Somnath Dutta;Jonathan R. Whicher;Douglas A. Hansen;Wendi A. Hale

  • Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site.

    Minsun Leesong;Barry S Henderson;James R Gillig;John M Schwab

  • Enzymes Utilizing Glutamine as an Amide Donor

    Howard Zalkin;Janet L. Smith

  • Structure of the allosteric regulatory enzyme of purine biosynthesis

    Janet L. Smith;Eugene J. Zaluzec;Eugene J. Zaluzec;Jean Pierre Wery;Jean Pierre Wery;Liwen Niu;Liwen Niu

  • The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.

    J.J Tesmer;T.J Klem;M.L Deras;V.J Davisson

  • The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.

    Kyung H. Choi;James M. Groarke;James M. Groarke;Dorothy C. Young;Richard J. Kuhn

  • SOME NEW STRUCTURAL ASPECTS AND OLD CONTROVERSIES CONCERNING THE CYTOCHROME b6f COMPLEX OF OXYGENIC PHOTOSYNTHESIS.

    W. A. Cramer;G. M. Soriano;M. Ponomarev;D. Huang

  • Coupled Formation of an Amidotransferase Interdomain Ammonia Channel and a Phosphoribosyltransferase Active Site

    Joseph M. Krahn;Jeong Hyun Kim;Mark R. Burns;Ronald J. Parry

  • Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4.

    D M Knipe;D Senechek;S A Rice;J L Smith

  • Structural heterogeneity in protein crystals

    Janet L. Smith;Wayne A. Hendrickson;Richard B. Honzatko;Steven Sheriff

  • Extended surface for membrane association in Zika virus NS1 structure

    W Clay Brown;David L Akey;Jamie R Konwerski;Jeffrey T Tarrasch

  • Structural rearrangements of a polyketide synthase module during its catalytic cycle.

    Jonathan R. Whicher;Somnath Dutta;Douglas A. Hansen;Wendi A. Hale

  • The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

    Jonathan M Goldberg;Gerard Manning;Allen Liu;Petra Fey

  • Biological identity and diversity in photosynthesis and respiration: structure of the lumen-side domain of the chloroplast Rieske protein

    Christopher J Carrell;Huamin Zhang;William A Cramer;Janet L Smith

  • Structure of the Flavivirus Helicase: Implications for Catalytic Activity, Protein Interactions, and Proteolytic Processing

    Jinhua Wu;Aloke Kumar Bera;Richard J. Kuhn;Janet L. Smith

Frequent Co-Authors

David H. Sherman
David H. Sherman University of Michigan–Ann Arbor
William H. Gerwick
William H. Gerwick University of California, San Diego
William A. Cramer
William A. Cramer Purdue University West Lafayette
Howard Zalkin
Howard Zalkin Purdue University West Lafayette
Richard Kuhn
Richard Kuhn Purdue University West Lafayette
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Robert M. Williams
Robert M. Williams Colorado State University
Georgios Skiniotis
Georgios Skiniotis Stanford University
Ruma Banerjee
Ruma Banerjee University of Michigan–Ann Arbor

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