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Chemistry

D-Index
106
Citations
42243
World Ranking
951
National Ranking
381

Biology and Biochemistry

D-Index
107
Citations
43245
World Ranking
1099
National Ranking
661

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William H. Gerwick is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields, primarily within biochemistry, genetics, and molecular biology, with significant contributions in medicine.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of their research focus are:

  • Molecular Biology
  • Pharmacology
  • Organic Chemistry
  • Biotechnology
  • Public Health, Environmental and Occupational Health

The central topics in William H. Gerwick's research encompass:

  • Microbial Natural Products and Biosynthesis
  • Metabolomics and Mass Spectrometry Studies
  • Marine Sponges and Natural Products
  • Computational Drug Discovery Methods
  • Ubiquitin and Proteasome Pathways
  • Genomics and Phylogenetic Studies
  • Research on Leishmaniasis Studies

Frequent co-authors collaborating with William H. Gerwick include:

  • Evgenia Glukhov
  • Lena Gerwick
  • Pieter C. Dorrestein
  • Anthony J. O'Donoghue
  • Jehad Almaliti

William H. Gerwick has published numerous papers in various venues. Among the frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Natural Products
  • ACS Chemical Biology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Marine Drugs

Selected recent papers include:

  • Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra, 2020, Nature Biotechnology
  • NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products, 2021, Journal of Natural Products
  • Artificial intelligence for natural product drug discovery, 2023, Nature Reviews Drug Discovery
  • A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products, 2020, Journal of the American Chemical Society
  • microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data, 2024, Nature Microbiology

William H. Gerwick received the honor of Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

    Mingxun Wang;Jeremy J Carver;Vanessa V Phelan;Laura M Sanchez

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • Marine natural products as anticancer drugs

    T Luke Simmons;Eric Andrianasolo;Kerry McPhail;Patricia Flatt

  • Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

    William H. Gerwick;Bradley S. Moore

  • Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

    Kai Dührkop;Louis Felix Nothias;Markus Fleischauer;Raphael Reher

  • Molecular Networking as a Dereplication Strategy

    Jane Y. Yang;Laura M. Sanchez;Christopher M. Rath;Xueting Liu

  • Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula

    Daniel J Edwards;Brian L Marquez;Lisa M Nogle;Kerry McPhail

  • Retrospective analysis of natural products provides insights for future discovery trends

    Cameron R. Pye;Matthew J. Bertin;R. Scott Lokey;William H. Gerwick

  • Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

    William H. Gerwick;Philip J. Proteau;Dale G. Nagle;Ernest Hamel

  • The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria.

    P. J. Proteau;W. H. Gerwick;W. H. Gerwick;F. Garcia-Pichel;F. Garcia-Pichel;R. Castenholz;R. Castenholz

  • Marine natural products as novel antioxidant prototypes.

    Satoshi Takamatsu;Tyler W. Hodges;Ira Rajbhandari;William H. Gerwick

  • NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products.

    Hyun Woo Kim;Mingxun Wang;Christopher A. Leber;Louis-Félix Nothias

  • Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth

    Emily M. Trentacoste;Roshan P. Shrestha;Sarah R. Smith;Corine Glé

  • Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

    Pascal Verdier-Pinard;Jing Yu Lai;Hae Dong Yoo;Jurong Yu

  • The Genomisotopic Approach: A Systematic Method to Isolate Products of Orphan Biosynthetic Gene Clusters

    Harald Gross;Harald Gross;Virginia O. Stockwell;Marcella D. Henkels;Brian Nowak-Thompson

  • Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula†

    Zunxue Chang;Namthip Sitachitta;James V. Rossi;Mary Ann Roberts

  • Artificial intelligence for natural product drug discovery

    Unknown

  • Biologically active secondary metabolites from marine cyanobacteria.

    Joshawna K Nunnery;Emily Mevers;William H Gerwick

  • The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

    Zunxue Chang;Patricia Flatt;William H. Gerwick;Viet Anh Nguyen

  • Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites.

    Niclas Engene;Erin C. Rottacker;Jan Kaštovský;Tara Byrum

  • Nitrogen-containing metabolites from marine cyanobacteria.

    William H Gerwick;Lik Tong Tan;Namthip Sitachitta

  • Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages

    T. Luke Simmons;R. Cameron Coates;Benjamin R. Clark;Niclas Engene

  • The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore

    Christopher S. Stevenson;Elizabeth A. Capper;Amy K. Roshak;Brian Marquez

Frequent Co-Authors

Pieter C. Dorrestein
Pieter C. Dorrestein University of California, San Diego
David H. Sherman
David H. Sherman University of Michigan–Ann Arbor
Bradley S. Moore
Bradley S. Moore University of California, San Diego
Janet L. Smith
Janet L. Smith University of Michigan–Ann Arbor
Roger G. Linington
Roger G. Linington Simon Fraser University
Thomas A. Kursar
Thomas A. Kursar University of Utah
Phyllis D. Coley
Phyllis D. Coley University of Utah
Pavel A. Pevzner
Pavel A. Pevzner University of California, San Diego
Nuno Bandeira
Nuno Bandeira University of California, San Diego
Christine L. Willis
Christine L. Willis University of Bristol

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