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Chemistry

D-Index
64
Citations
11631
World Ranking
8209
National Ranking
2372

Biology and Biochemistry

D-Index
65
Citations
12163
World Ranking
9358
National Ranking
4128

Overview

Hendrik Luesch is affiliated with the University of Florida in the United States and has contributed extensively to research in biochemistry, genetics, and molecular biology, with additional works in medicine. Their research spans multiple subfields including molecular biology, pharmacology, biotechnology, organic chemistry, and materials chemistry.

The primary focus of Luesch's research includes microbial natural products and biosynthesis, marine sponges and natural products, algal biology and biofuel production, computational drug discovery methods, chemical synthesis and analysis, crystallization and solubility studies, and X-ray diffraction in crystallography.

Luesch has published papers in several frequent venues such as:

  • Natural Product Reports
  • Journal of Natural Products
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database
  • Organic Letters

Among their recent papers are:

  • "Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWTand EGFRT790M" (2020) in Organic & Biomolecular Chemistry
  • "Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site" (2021) in Proceedings of the National Academy of Sciences
  • "Natural products as modulators of eukaryotic protein secretion" (2020) in Natural Product Reports
  • "Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties" (2020) in ACS Chemical Biology
  • "High-throughput gene screen reveals modulators of nuclear shape" (2020) in Molecular Biology of the Cell

Collaboration has been an integral part of Luesch's research activities. Frequent coauthors include:

  • Ranjala Ratnayake
  • Valerie J. Paul
  • Qi-Yin Chen
  • Yousong Ding
  • Gustavo Seabra

Best Publications

  • Marine natural products: a new wave of drugs?

    Rana Montaser;Hendrik Luesch

  • Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

    Kanchan Taori;Valerie J Paul;Hendrik Luesch

  • Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.

    Hendrik Luesch;Richard E. Moore;Valerie J. Paul;Susan L. Mooberry

  • Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.

    Hendrik Luesch;Wesley Y. Yoshida;Richard E. Moore;Valerie J. Paul

  • Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.

    Hsiangling Teo;Sourav Ghosh;Hendrik Luesch;Hendrik Luesch;Arkasubhra Ghosh

  • Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.

    Yongcheng Ying;Kanchan Taori;Hyoungsu Kim;Jiyong Hong

  • Isolation, Structure Determination, and Biological Activity of Lyngbyabellin A from the Marine Cyanobacterium Lyngbya majuscula

    Hendrik Luesch;Wesley Y. Yoshida;Richard E. Moore;Valerie J. Paul

  • A genomic screen for activators of the antioxidant response element.

    Yanxia Liu;Jonathan T. Kern;John R. Walker;Jeffrey A. Johnson

  • New apratoxins of marine cyanobacterial origin from Guam and Palau.

    Hendrik Luesch;Wesley Y Yoshida;Richard E Moore;Valerie J Paul

  • Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

    George G. Harrigan;Hendrik Luesch;Wesley Y. Yoshida;Richard E. Moore

  • Largazole: From discovery to broad-spectrum therapy

    Jiyong Hong;Hendrik Luesch

  • A functional genomics approach to the mode of action of apratoxin A

    Hendrik Luesch;Hendrik Luesch;Sumit K Chanda;R Marina Raya;Paul D DeJesus

  • The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares

    H. Luesch;G. G. Harrigan;G. Goetz;F. D. Horgen

  • Biological targets and mechanisms of action of natural products from marine cyanobacteria

    Lilibeth A. Salvador-Reyes;Lilibeth A. Salvador-Reyes;Hendrik Luesch

  • Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

    Yanxia Liu;Brian K. Law;Hendrik Luesch

  • Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.

    Susan Matthew;Peter J Schupp;Hendrik Luesch

  • Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

    Yanxia Liu;Lilibeth A. Salvador;Seongrim Byeon;Yongcheng Ying

  • Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.

    Hendrik Luesch;Ronald Pangilinan;Wesley Y. Yoshida;Richard E. Moore

  • Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.

    Rui Wang;Valerie J. Paul;Hendrik Luesch

  • Lyngbyastatins 5–7, Potent Elastase Inhibitors from Floridian Marine Cyanobacteria, Lyngbya spp.

    Kanchan Taori;Susan Matthew;James R. Rocca;Valerie J. Paul

  • Symplostatin 2: a dolastatin 13 analogue from the marine cyanobacterium Symploca hydnoides.

    George G. Harrigan;Hendrik Luesch;Wesley Y. Yoshida;Richard E. Moore

Frequent Co-Authors

Valerie J. Paul
Valerie J. Paul Smithsonian Institution
Richard E. Moore
Richard E. Moore University of Hawaii at Manoa
Wesley Y. Yoshida
Wesley Y. Yoshida University of Hawaii at Manoa
Tao Ye
Tao Ye Pennsylvania State University
Khalil A. Abboud
Khalil A. Abboud University of Florida
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Shouguang Jin
Shouguang Jin Franklin College
Max Teplitski
Max Teplitski University of Florida
Walter Hunziker
Walter Hunziker Agency for Science, Technology and Research
Yi Zhang
Yi Zhang Xidian University

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