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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
32191
World Ranking
1907
National Ranking
45

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Hilal A. Lashuel is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research predominantly spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific focus areas in Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Physiology, and Biomedical Engineering.

Their work extensively addresses topics related to Parkinson's Disease Mechanisms and Treatments, Genetic Neurodegenerative Diseases, Neurological Disorders and Treatments, Alzheimer's Disease Research and Treatments, Mitochondrial Function and Pathology, Botulinum Toxin and Related Neurological Disorders, and Neurological Diseases and Metabolism.

Among recent notable publications, the following papers illustrate the focus and impact of their research:

  • The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration (2020, Proceedings of the National Academy of Sciences)
  • Half a century of amyloids: past, present and future (2020, Chemical Society Reviews)
  • Reverse engineering Lewy bodies: how far have we come and how far can we go? (2021, Nature Reviews. Neuroscience)
  • Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease (2021, npj Parkinson s Disease)
  • How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology (2020, Neurobiology of Disease)

Frequently publishing venues for this researcher include bioRxiv (Cold Spring Harbor Laboratory), npj Parkinson s Disease, Nature Communications, Neurobiology of Disease, and Science Advances.

Collaboration is a notable aspect of their work, with frequent coauthors including Anass Chiki, Anne-Laure Mahul-Mellier, Senthil T. Kumar, Nathan Riguet, and Pedro Magalhães.

Best Publications

  • Neurodegenerative disease: amyloid pores from pathogenic mutations.

    Hilal A. Lashuel;Dean Hartley;Benjamin M. Petre;Thomas Walz

  • The many faces of α-synuclein: from structure and toxicity to therapeutic target

    Hilal A. Lashuel;Cassia R. Overk;Abid Oueslati;Eliezer Masliah

  • The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

    Yichin Liu;Lara Fallon;Hilal A. Lashuel;Zhihua Liu

  • α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

    Hilal A. Lashuel;Benjamin M. Petre;Joseph Wall;Martha Simon

  • A century-old debate on protein aggregation and neurodegeneration enters the clinic

    Peter T. Lansbury;Hilal A. Lashuel

  • The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

    Anne-Laure Mahul-Mellier;Johannes Burtscher;Niran Maharjan;Laura Weerens

  • Amyloidogenic Protein–Membrane Interactions: Mechanistic Insight from Model Systems

    Sara M. Butterfield;Hilal A. Lashuel

  • α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

    Bruno Fauvet;Martial Kamdem Mbefo;Mohamed-Bilal Fares;Carole Desobry

  • Half a century of amyloids: past, present and future

    Pu Chun Ke;Pu Chun Ke;Ruhong Zhou;Ruhong Zhou;Louise C. Serpell;Roland Riek

  • Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

    Hilal A. Lashuel;Peter T. Lansbury

  • Inhibiting transthyretin amyloid fibril formation via protein stabilization

    Greta J. Miroy;Zhihong Lai;Hilal A. Lashuel;Scott A. Peterson

  • Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

    Katerina E. Paleologou;Adrian W. Schmid;Carla C. Rospigliosi;Hai Young Kim

  • Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies.

    Abid Oueslati;Margot Fournier;Hilal A. Lashuel

  • Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

    Katerina E. Paleologou;Abid Oueslati;Gideon Shakked;Carla C. Rospigliosi

  • Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: Implications for amyloid fibril formation and materials science

    Hilal A. Lashuel;Steven R. LaBrenz;Linda Woo;Louise C. Serpell

  • Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

    Yichin Liu;Yichin Liu;Hilal A. Lashuel;Hilal A. Lashuel;Sungwoon Choi;Xuechao Xing

  • Amyloid-β Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

    Igor Allaman;Mathilde Gavillet;Mireille Bélanger;Thierry Laroche

  • The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.

    Asad Jan;Ozgun Gokce;Ruth Luthi-Carter;Hilal A. Lashuel

  • Mixtures of Wild-type and a Pathogenic (E22G) Form of Aβ40 in Vitro Accumulate Protofibrils, Including Amyloid Pores☆

    Hilal A. Lashuel;Dean M. Hartley;Dean M. Hartley;Benjamin M. Petre;Joseph S. Wall

  • The Impact of the E46K Mutation on the Properties of α-Synuclein in Its Monomeric and Oligomeric States†

    Ross A. Fredenburg;Carla Rospigliosi;Robin K. Meray;Jeffrey C. Kessler

Frequent Co-Authors

Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Jeffery W. Kelly
Jeffery W. Kelly Scripps Research Institute
Giovanni Dietler
Giovanni Dietler École Polytechnique Fédérale de Lausanne
Peter T. Lansbury
Peter T. Lansbury Harvard University
David Eliezer
David Eliezer Cornell University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Thomas Walz
Thomas Walz Rockefeller University
Hugo Vanderstichele
Hugo Vanderstichele Fujirebio (Belgium)
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne

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