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Biology and Biochemistry

D-Index
65
Citations
16305
World Ranking
9092
National Ranking
4039

Overview

David Eliezer is affiliated with Cornell University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant focus also on medicine.

The scientist's work touches on several key subfields including molecular biology, neurology, physiology, cellular and molecular neuroscience, and cell biology. This broad range supports their focused research topics which include:

  • Parkinson's disease mechanisms and treatments
  • Alzheimer's disease research and treatments
  • Cellular transport and secretion
  • Neuroscience and neuropharmacology research
  • Protein structure and dynamics
  • Genetic neurodegenerative diseases
  • Receptor mechanisms and signaling

David Eliezer's recent publications demonstrate ongoing contributions to the understanding of neurodegenerative disease mechanisms and protein behavior. Notable papers include:

  • "Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration" (2020) published in Nature Neuroscience
  • "Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease" (2022) published in Nature Communications
  • "Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog" (2020) published in Nature Chemical Biology
  • "Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau" (2020) published in Journal of Biological Chemistry
  • "Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands" (2021) published in International Journal of Biological Macromolecules

Their frequent coauthors include Diana Acosta, Trudy F. Ramlall, Yun Huang, Tapojyoti Das, and Guohua Lv.

David Eliezer has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Journal of Biological Chemistry, Methods in Molecular Biology, and Nature Communications.

Best Publications

  • Conformational properties of alpha-synuclein in its free and lipid-associated states.

    David Eliezer;Esin Kutluay;Robert Bussell;Gillian Browne

  • α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

    Bruno Fauvet;Martial Kamdem Mbefo;Mohamed-Bilal Fares;Carole Desobry

  • A Structural and Functional Role for 11-mer Repeats in α-Synuclein and Other Exchangeable Lipid Binding Proteins

    Robert Bussell;David Eliezer

  • Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding.

    David Eliezer;Jian Yao;H. Jane Dyson;Peter E. Wright

  • Intracellular cholesterol transport

    Frederick R. Maxfield;Daniel Wüstner

  • Biophysical characterization of intrinsically disordered proteins.

    David Eliezer

  • Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

    Katerina E. Paleologou;Adrian W. Schmid;Carla C. Rospigliosi;Hai Young Kim

  • Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.

    Vladimir N Uversky;David Eliezer

  • Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

    Katerina E. Paleologou;Abid Oueslati;Gideon Shakked;Carla C. Rospigliosi

  • Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

    Elka R. Georgieva;Trudy F. Ramlall;Peter P. Borbat;Jack H. Freed

  • Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of α-Synuclein

    Robert Bussell;David Eliezer

  • Is apomyoglobin a molten globule? Structural characterization by NMR.

    David Eliezer;Peter E. Wright

  • Quantification of α-Synuclein Binding to Lipid Vesicles Using Fluorescence Correlation Spectroscopy

    Elizabeth Rhoades;Trudy F. Ramlall;Watt W. Webb;David Eliezer

  • The Impact of the E46K Mutation on the Properties of α-Synuclein in Its Monomeric and Oligomeric States†

    Ross A. Fredenburg;Carla Rospigliosi;Robin K. Meray;Jeffrey C. Kessler

  • NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding.

    J Yao;J Chung;D Eliezer;P E Wright

  • Structural Basis for Recognition of Diubiquitins by NEMO

    Yu Chih Lo;Su Chang Lin;Carla C. Rospigliosi;Dietrich B. Conze

  • The Novel Parkinson's Disease Linked Mutation G51D Attenuates In Vitro Aggregation and Membrane Binding of α-Synuclein, and Enhances its Secretion and Nuclear Localization in Cells

    Mohamed Bilal Fares;Nadine Ait-Bouziad;Igor Dikiy;Martial K. Mbefo

  • Alpha-Synuclein Function and Dysfunction on Cellular Membranes

    David Snead;David Eliezer

  • Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation

    Valerie L. Anderson;Trudy F. Ramlall;Carla C. Rospigliosi;Watt W. Webb

  • c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

    Anne Laure Mahul-Mellier;Bruno Fauvet;Amanda Gysbers;Igor Dikiy

Frequent Co-Authors

Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Keith O. Hodgson
Keith O. Hodgson Stanford University
Sebastian Doniach
Sebastian Doniach Stanford University
Peter E. Wright
Peter E. Wright Scripps Research Institute
Omar M. A. El-Agnaf
Omar M. A. El-Agnaf Hamad bin Khalifa University
Barbara Baird
Barbara Baird Cornell University
Jack H. Freed
Jack H. Freed Cornell University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Anant K. Menon
Anant K. Menon Cornell University
David Holowka
David Holowka Cornell University

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