World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
91
Citations
30152
World Ranking
1963
National Ranking
145

Biology and Biochemistry

D-Index
96
Citations
33628
World Ranking
1825
National Ranking
122

Overview

Markus Zweckstetter is affiliated with the German Center for Neurodegenerative Diseases in Germany, focusing his research primarily in biochemistry, genetics, and molecular biology. His work encompasses a broad range of topics related to molecular biology and neurology, with an emphasis on mechanisms underlying neurodegenerative diseases.

The main fields of study in Zweckstetter's research include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these areas, the subfields of study he contributes to are:

  • Molecular Biology
  • Neurology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Cell Biology

His research topics cover:

  • RNA Research and Splicing
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Protein Structure and Dynamics
  • Heat shock proteins research
  • RNA modifications and cancer
  • Neurological disorders and treatments

Zweckstetter has contributed to numerous publications, often appearing in certain key academic venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Protein Science
  • Angewandte Chemie International Edition
  • Proceedings of the National Academy of Sciences

Frequent co-authors in his research include:

  • Alain Ibáñez de Opakua
  • Stefan Becker
  • Maria-Sol Cima-Omori
  • Adriana Savastano
  • Pijush Chakraborty

Among his recent published papers are:

  • "Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates," 2020, Nature Communications
  • "Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry," 2022, Chemical Reviews
  • "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease," 2021, npj Parkinson's Disease
  • "Molecular Basis of Small-Molecule Binding to α-Synuclein," 2022, Journal of the American Chemical Society
  • "Liquid-liquid phase separation of tau: From molecular biophysics to physiology and disease," 2021, Protein Science

Best Publications

  • N-acetyltransferase 8-like accelerates lipid turnover and increases energy in brown adipocytes

    Ariane Pessentheiner;Helmut Josef Pelzmann;Evelyn Walenta;Martina Schweiger

  • Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein

    Carlos W. Bertoncini;Young-Sang Jung;Claudio O. Fernandez;Wolfgang Hoyer

  • VDAC, a multi-functional mitochondrial protein regulating cell life and death.

    Varda Shoshan-Barmatz;Vito De Pinto;Markus Zweckstetter;Ziv Raviv

  • Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

    Susmitha Ambadipudi;Jacek Biernat;Dietmar Riedel;Eckhard Mandelkow

  • Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

    Marco D Mukrasch;Stefan Bibow;Jegannath Korukottu;Sadasivam Jeganathan

  • Structure of the human voltage-dependent anion channel

    Monika Bayrhuber;Thomas Meins;Michael Habeck;Stefan Becker

  • RNA polymerase II clustering through carboxy-terminal domain phase separation

    Marc Boehning;Claire Dugast-Darzacq;Marija Rankovic;Anders S Hansen

  • Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

    Harindranath Kadavath;Romina V. Hofele;Jacek Biernat;Satish Kumar

  • Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

    Damla Pinar Karpinar;Madhu Babu Gajula Balija;Sebastian Kügler;Felipe Opazo

  • Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

    Rodolfo M. Rasia;Carlos W. Bertoncini;Derek Marsh;Wolfgang Hoyer

  • Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

    Jens Wagner;Sergey Ryazanov;Sergey Ryazanov;Andrei Leonov;Andrei Leonov;Johannes Levin

  • Structural Ensembles of Intrinsically Disordered Proteins Depend Strongly on Force Field: A Comparison to Experiment

    Sarah Rauscher;Vytautas Gapsys;Michal J. Gajda;Markus Zweckstetter;Markus Zweckstetter;Markus Zweckstetter

  • Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

    Katerina E. Paleologou;Adrian W. Schmid;Carla C. Rospigliosi;Hai Young Kim

  • Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.

    Andrés Binolfi;Rodolfo M. Rasia;Carlos W. Bertoncini;Marcelo Ceolin

  • NMR: prediction of molecular alignment from structure using the PALES software.

    Markus Zweckstetter

  • Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates.

    Adriana Savastano;Alain Ibáñez de Opakua;Marija Rankovic;Markus Zweckstetter;Markus Zweckstetter

  • Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

    Katerina E. Paleologou;Abid Oueslati;Gideon Shakked;Carla C. Rospigliosi

  • Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions.

    Marco D. Mukrasch;Jacek Biernat;Martin von Bergen;Christian Griesinger

  • Mars -- robust automatic backbone assignment of proteins.

    Young-Sang Jung;Markus Zweckstetter

  • Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

    G. Elif Karagöz;G. Elif Karagöz;Afonso M.S. Duarte;Afonso M.S. Duarte;Elias Akoury;Hans Ippel;Hans Ippel

Frequent Co-Authors

Stefan Becker
Stefan Becker Max Planck Society
Christian Griesinger
Christian Griesinger Max Planck Society
Jacek Biernat
Jacek Biernat German Center for Neurodegenerative Diseases
Eckhard Mandelkow
Eckhard Mandelkow German Center for Neurodegenerative Diseases
Tiago F. Outeiro
Tiago F. Outeiro University of Göttingen
Martin Blackledge
Martin Blackledge Grenoble Alpes University
Henning Urlaub
Henning Urlaub University of Göttingen
Adam Lange
Adam Lange Humboldt-Universität zu Berlin
Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Bert L. de Groot
Bert L. de Groot Max Planck Society

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