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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
16097
World Ranking
9102
National Ranking
82

Overview

Varda Shoshan-Barmatz is affiliated with Ben-Gurion University of the Negev in Israel and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their scholarly work encompasses detailed studies on mitochondrial function and pathology, ATP synthase and ATPases research, cancer, hypoxia, metabolism, immune responses involving interferons, metabolism and genetic disorders, cell death mechanisms and regulation, and inflammasomes in immune disorders.

The scientist's publication record includes significant contributions in multiple fields with a particular emphasis on mitochondrial-related diseases and cellular metabolism. Key recent papers include:

  • VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases, 2020, Biomolecules
  • The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target, 2021, Molecular Therapy
  • Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer's disease protects against mitochondrial dysfunction and mitigates brain pathology, 2022, Translational Neurodegeneration
  • Apoptotic proteins with non-apoptotic activity: expression and function in cancer, 2023, APOPTOSIS
  • Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?, 2021, Frontiers in Physiology

Their work frequently appears in journals such as Biomolecules, Cancers, Molecular Therapy, APOPTOSIS, and Cells, indicating a strong presence in high-impact molecular biology and medicine venues.

Collaborations are an integral part of their research output, with frequent co-authors including Anna Shteinfer-Kuzmine, Swaroop Kumar Pandey, Ankit Verma, Srinivas Pittala, and Avijit Kumar Paul. These collaborations reflect an active engagement with peers in advancing studies on mitochondrial proteins, immune mechanisms, and cancer biology.

The scientist's research topics cover a wide area, including:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Cancer, Hypoxia, and Metabolism
  • Interferon and Immune Responses
  • Metabolism and Genetic Disorders
  • Cell Death Mechanisms and Regulation
  • Inflammasome and Immune Disorders

Within the broader scientific fields, the focus remains primarily on molecular biology, immunology, cancer research, clinical biochemistry, and epidemiology, demonstrating an interdisciplinary approach to understanding cellular function and disease mechanisms.

Best Publications

  • VDAC, a multi-functional mitochondrial protein regulating cell life and death.

    Varda Shoshan-Barmatz;Vito De Pinto;Markus Zweckstetter;Ziv Raviv

  • NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

    Raz Palty;William F. Silverman;Michal Hershfinkel;Teresa Caporale

  • VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.

    Jeonghan Kim;Rajeev Gupta;Luz P. Blanco;Shutong Yang

  • In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.

    Heftsi Azoulay-Zohar;Adrian Israelson;Salah Abu-Hamad;Varda Shoshan-Barmatz

  • Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function.

    Dan Gincel;Hilal Zaid;Varda Shoshan-Barmatz

  • The Voltage-Dependent Anion Channel (VDAC): Function in Intracellular Signalling, Cell Life and Cell Death

    V. Shoshan-Barmatz;A. Israelson;D. Brdiczka;S. S. Sheu

  • The voltage-dependent anion channel-1 modulates apoptotic cell death.

    H Zaid;S Abu-Hamad;A Israelson;I Nathan

  • Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

    Adrian Israelson;Nir Arbel;Sandrine Da Cruz;Hristelina Ilieva

  • The expression level of the voltage-dependent anion channel controls life and death of the cell

    Salah Abu-Hamad;Sara Sivan;Varda Shoshan-Barmatz

  • Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

    Nurit Keinan;Dalia Tyomkin;Varda Shoshan-Barmatz

  • The voltage-dependent anion channel: characterization, modulation, and role in mitochondrial function in cell life and death.

    Varda Shoshan-Barmatz;Dan Gincel

  • Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

    Salah Abu-Hamad;Hilal Zaid;Adrian Israelson;Edna Nahon

  • VDAC, a multi-functional mitochondrial protein as a pharmacological target.

    Varda Shoshan-Barmatz;Danya Ben-Hail

  • The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.

    Salah Abu-Hamad;Nir Arbel;Doron Calo;Laetitia Arzoine

  • Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria.

    Ran Zalk;Adrian Israelson;Erez S. Garty;Heftsi Azoulay-Zohar

  • The mitochondrial voltage-dependent anion channel 1 in tumor cells.

    Varda Shoshan-Barmatz;Danya Ben-Hail;Lee Admoni;Yakov Krelin

  • Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

    N Goldin;L Arzoine;A Heyfets;A Israelson

  • VDAC1, mitochondrial dysfunction, and Alzheimer's disease.

    Varda Shoshan-Barmatz;Edna Nahon-Crystal;Anna Shteinfer-Kuzmine;Rajeev Gupta

  • Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity

    Laetitia Arzoine;Noam Zilberberg;Ronit Ben-Romano;Varda Shoshan-Barmatz

  • Voltage-dependent Anion Channel 1-based Peptides Interact with Bcl-2 to Prevent Antiapoptotic Activity

    Nir Arbel;Varda Shoshan-Barmatz

Frequent Co-Authors

Helmut E. Meyer
Helmut E. Meyer Ruhr University Bochum
Claes B. Wollheim
Claes B. Wollheim University of Geneva
Leif Groop
Leif Groop Lund University
Lorenzo Galluzzi
Lorenzo Galluzzi Cornell University
John J. Lemasters
John J. Lemasters Medical University of South Carolina
Koji Yamanaka
Koji Yamanaka Nagoya University
Israel Sekler
Israel Sekler Ben-Gurion University of the Negev
Sidney Fleischer
Sidney Fleischer Vanderbilt University
Eric H. Davidson
Eric H. Davidson California Institute of Technology

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