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Biology and Biochemistry

D-Index
51
Citations
9173
World Ranking
17193
National Ranking
172

Overview

Israel Sekler is affiliated with Ben-Gurion University of the Negev in Israel and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on mitochondrial function and pathology, neuroscience and neuropharmacology, and ion transport and channel regulation.

The scientist's publication record includes work across several subfields such as molecular biology, cellular and molecular neuroscience, physiology, nutrition and dietetics, and epidemiology. Sekler's research topics notably involve mitochondrial function and pathology, ion channel regulation and function, ATP synthase and ATPases, Alzheimer's disease research and treatments, and the role of trace elements in health.

Israel Sekler has published numerous papers, with some of the recent notable contributions being:

  • "Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis" (2020, eLife)
  • "Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation" (2021, Communications Biology)
  • "Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease" (2022, Proceedings of the National Academy of Sciences)
  • "NCLX prevents cell death during adrenergic activation of the brown adipose tissue" (2020, Nature Communications)
  • "Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica" (2020, International Journal of Molecular Sciences)

Their work has appeared frequently in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Calcium, SSRN Electronic Journal, eLife, and Communications Biology.

Israel Sekler collaborates regularly with several co-authors, including:

  • Michal Hershfinkel (15 collaborations)
  • Grace E. Stutzmann (7 collaborations)
  • Essam A. Assali (7 collaborations)
  • Alexandra Stavsky (7 collaborations)
  • Hila Asraf (6 collaborations)

Best Publications

  • Zinc in the physiology and pathology of the CNS.

    Stefano L. Sensi;Pierre Paoletti;Ashley I. Bush;Ashley I. Bush;Israel Sekler

  • NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

    Raz Palty;William F. Silverman;Michal Hershfinkel;Teresa Caporale

  • Role of GPR40 in fatty acid action on the β cell line INS-1E

    Hagit Shapiro;Sigal Shachar;Israel Sekler;Michal Hershfinkel

  • A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport

    Michal Hershfinkel;Arie Moran;Nili Grossman;Israel Sekler

  • Mechanism and regulation of cellular zinc transport.

    Israel Sekler;Stefano L. Sensi;Michal Hershfinkel;William F. Silverman

  • Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus

    Limor Besser;Ehud Chorin;Israel Sekler;William F. Silverman

  • Identification of the Zn2+ Binding Site and Mode of Operation of a Mammalian Zn2+ Transporter

    Ehud Ohana;Eitan Hoch;Chen Keasar;Taiho Kambe

  • The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

    Andrei I. Tarasov;Francesca Semplici;Magalie A. Ravier;Magalie A. Ravier;Elisa A. Bellomo

  • The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.

    T C Pozos;I Sekler;M S Cyert

  • NCLX: the mitochondrial sodium calcium exchanger.

    Liron Boyman;George S.B. Williams;George S.B. Williams;Daniel Khananshvili;Israel Sekler

  • Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor

    Ehud Chorin;Ofir Vinograd;Ilya Fleidervish;David Gilad

  • PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.

    Marko Kostic;Marthe H.R. Ludtmann;Hilmar Bading;Michal Hershfinkel

  • Lithium-Calcium Exchange Is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger *

    Raz Palty;Ehud Ohana;Michal Hershfinkel;Micha Volokita

  • Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity

    Eitan Hoch;Wei Lin;Jin Chai;Michal Hershfinkel

  • The Zinc Sensing Receptor, a Link Between Zinc and Cell Signaling

    Michal Hershfinkel;William F. Silverman;Israel Sekler

  • Zinc Released from Injured Cells Is Acting via the Zn2+-sensing Receptor, ZnR, to Trigger Signaling Leading to Epithelial Repair

    Haleli Sharir;Anna Zinger;Andrey Nevo;Israel Sekler

  • ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc

    Christiane Nolte;Ariel Gore;Israel Sekler;Wolfgang Kresse

  • Mitochondrial Exchanger NCLX Plays a Major Role in the Intracellular Ca2+ Signaling, Gliotransmission, and Proliferation of Astrocytes

    Julia Parnis;Vedrana Montana;Ignacio Delgado-Martinez;Vitali Matyash

  • Distribution of the zinc transporter ZnT‐1 in comparison with chelatable zinc in the mouse brain

    Israel Sekler;Arie Moran;Michal Hershfinkel;Amir Dori

  • NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+ Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State

    Umberto De Marchi;Umberto De Marchi;Jaime Santo-Domingo;Jaime Santo-Domingo;Cyril Castelbou;Israel Sekler

Frequent Co-Authors

Elias Aizenman
Elias Aizenman University of Pittsburgh
Uri Pick
Uri Pick Weizmann Institute of Science
Orian S. Shirihai
Orian S. Shirihai University of California, Los Angeles
Guy A. Rutter
Guy A. Rutter Imperial College London
Mohamed Trebak
Mohamed Trebak Pennsylvania State University
Ron R. Kopito
Ron R. Kopito Stanford University
Donald L. Gill
Donald L. Gill Pennsylvania State University
Glen K. Andrews
Glen K. Andrews University of Kansas
Helmut Kettenmann
Helmut Kettenmann Shenzhen Institutes of Advanced Technology
Mark Stoneking
Mark Stoneking Max Planck Society

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