2023 - Research.com Medicine in Australia Leader Award
2023 - Research.com Biology and Biochemistry in Australia Leader Award
His primary areas of study are Alzheimer's disease, Biochemistry, Amyloid, Oxidative stress and Amyloid precursor protein. His Alzheimer's disease study deals with the bigger picture of Internal medicine. Ashley I. Bush interconnects PBT2 and Copper in the investigation of issues within Biochemistry.
The Amyloid study combines topics in areas such as P3 peptide, Stereochemistry and Pathogenesis. His study in Oxidative stress is interdisciplinary in nature, drawing from both Neurotoxicity, Neuroscience, Mitochondrion and Hyperphosphorylation. His Amyloid precursor protein research incorporates themes from Molecular biology, Endocrinology, Ferroxidase activity and Cell biology.
Internal medicine, Alzheimer's disease, Disease, Biochemistry and Endocrinology are his primary areas of study. Ashley I. Bush works mostly in the field of Internal medicine, limiting it down to concerns involving Zinc and, occasionally, Copper. The concepts of his Alzheimer's disease study are interwoven with issues in Amyloid beta, Neurodegeneration, Dementia, Cognitive decline and Amyloid.
His study looks at the intersection of Disease and topics like Neuroscience with Parkinson's disease and Alpha-synuclein. In his research, Cell biology is intimately related to Amyloid precursor protein, which falls under the overarching field of Biochemistry. His work is dedicated to discovering how Oxidative stress, Pharmacology are connected with Toxicity and other disciplines.
Ashley I. Bush mainly focuses on Disease, Cognitive decline, Internal medicine, Neurodegeneration and Alzheimer's disease. His Cognitive decline research includes elements of Amyloid beta, Long-term potentiation, Ferritin, Apolipoprotein E and Amyloid. His Internal medicine research incorporates elements of Endocrinology, Oncology and Schizophrenia.
His Neurodegeneration study combines topics from a wide range of disciplines, such as Oxidative stress, Neuroscience, Neuroprotection, Amyloid precursor protein and Cell biology. His work deals with themes such as Rotenone and Neurotoxicity, Toxicity, which intersect with Amyloid precursor protein. His Alzheimer's disease research includes themes of Cerebrospinal fluid, Immunology, Dementia, Biomarker and Positron emission tomography.
Ashley I. Bush spends much of his time researching Alzheimer's disease, Neurodegeneration, Cognitive decline, Internal medicine and Neuroscience. Alzheimer's disease is a subfield of Disease that Ashley I. Bush tackles. He combines subjects such as Substantia nigra, GPX4, Neuroprotection, Amyloid precursor protein and Ferritin with his study of Neurodegeneration.
He has included themes like Oxidative stress, Apolipoprotein E and Cerebrospinal fluid in his Cognitive decline study. His Internal medicine research is multidisciplinary, incorporating elements of Bipolar disorder, Endocrinology, Neuropsychological assessment and Schizophrenia. When carried out as part of a general Neuroscience research project, his work on Blood–brain barrier is frequently linked to work in Quantitative susceptibility mapping, therefore connecting diverse disciplines of study.
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Neurodegenerative diseases and oxidative stress.
Kevin J. Barnham;Colin L. Masters;Ashley I. Bush;Ashley I. Bush.
Nature Reviews Drug Discovery (2004)
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell;José Pedro Friedmann Angeli;Hülya Bayir;Ashley I. Bush.
Cell (2017)
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
Catriona A. McLean;Robert A. Cherny;Fiona W. Fraser;Stephanie J. Fuller.
Annals of Neurology (1999)
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Ashley I. Bush;Warren H. Pettingell;Gerd Multhaup;Marc D. Paradis.
Science (1994)
The neurobiology of zinc in health and disease
Christopher J. Frederickson;Jae-Young Koh;Ashley I. Bush;Ashley I. Bush.
Nature Reviews Neuroscience (2005)
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
Robert A Cherny;Craig S Atwood;Michel E Xilinas;Danielle N Gray.
Neuron (2001)
The metallobiology of Alzheimer's disease.
Ashley I. Bush.
Trends in Neurosciences (2003)
The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†
Xudong Huang;Craig S. Atwood;Mariana A. Hartshorn;Gerd Multhaup.
Biochemistry (1999)
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
C. S. Atwood;R. D. Moir;Xudong Huang;R. C. Scarpa.
Journal of Biological Chemistry (1998)
Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial
Craig W Ritchie;Ashley I Bush;Andrew J Mackinnon;Steve Macfarlane.
JAMA Neurology (2003)
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