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Biology and Biochemistry
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2023

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Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Medicine in United Kingdom Leader Award
  • 2022 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Mark A. Smith was affiliated with Case Western Reserve University in the United States. Their research spanned multiple interconnected fields within biochemistry, genetics, and molecular biology.

The scientist produced work concentrated mainly in cellular mechanics and interactions, cardiomyopathy and myosin studies, force microscopy techniques and applications, nuclear structure and function, RNA research and splicing, as well as microtubule and mitosis dynamics.

Smith contributed to the academic literature through publications in several journals, including:

  • Developmental Cell
  • Molecular Biology of the Cell
  • Heliyon
  • bioRxiv (Cold Spring Harbor Laboratory)

Among their recent papers were:

  • "Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains," 2020, published in Developmental Cell
  • "Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes," 2020, published in Molecular Biology of the Cell
  • "Nuclear pore complexes concentrate on Actin/LINC/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner," 2022, published in Heliyon
  • "Mechanosensing through direct binding of tensed F-actin by LIM domains," 2020, posted on bioRxiv (Cold Spring Harbor Laboratory)

Smith frequently collaborated with researchers including Elizabeth Blankman, Mary C. Beckerle, Xiaoyu Sun, Donovan Y.Z. Phua, and Lucas Axiotakis. These collaborations likely enriched their interdisciplinary exploration of molecular and cellular mechanisms.

The scientist's work was classified predominantly under biochemistry, genetics, and molecular biology, with a significant number of publications specifically in cell biology and molecular biology. Additional subfields included cardiology and cardiovascular medicine as well as atomic and molecular physics and optics.

The main scientific topics addressed by Smith focused on cellular mechanics and interactions, studies on cardiomyopathy and myosin, advanced force microscopy techniques, nuclear structure and function investigations, RNA biology and splicing processes, and dynamics related to microtubules and mitosis.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Oxidative damage is the earliest event in Alzheimer disease.

    Akihiko Nunomura;George Perry;Gjumrakch Aliev;Keisuke Hirai;Keisuke Hirai

  • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.

    Mark A. Smith;Peggy L. R. Harris;Lawrence M. Sayre;George Perry

  • Mitochondrial abnormalities in Alzheimer's disease.

    Keisuke Hirai;Gjumrakch Aliev;Akihiko Nunomura;Akihiko Nunomura;Hisashi Fujioka

  • Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

    Mark A. Smith;Peggy L. Richey Harris;Lawrence M. Sayre;Joseph S. Beckman

  • Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

    Xinglong Wang;Bo Su;Hyoung Gon Lee;Xinyi Li

  • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

    Lawrence M. Sayre;Dawn A. Zelasko;Peggy L. R. Harris;George Perry

  • Best Care at Lower Cost: The Path to Continuously Learning Health Care in America

    Mark Smith;Robert Saunders;Leigh Stuckhardt;J. Michael McGinnis

  • Oxidative damage in Alzheimer's

    M A Smith;G Perry;P L Richey;L M Sayre

  • Oxidative stress in Alzheimer's disease.

    Mark A. Smith;Catherine A. Rottkamp;Akihiko Nunomura;Arun K. Raina

  • Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

    Angelika Bierhaus;Stephan Schiekofer;Stephan Schiekofer;Markus Schwaninger;Martin Andrassy;Martin Andrassy

  • HIV-1 protease inhibitors. A review for clinicians.

    Steven G. Deeks;Mark Smith;Mark Holodniy;James O. Kahn

  • Oxidative stress and neurotoxicity

    Lawrence M. Sayre;George Perry;Mark A. Smith

  • Advanced Maillard reaction end products are associated with Alzheimer disease pathology

    Mark A. Smith;Shinji Taneda;Peggy L. Richey;Satoshi Miyata

  • RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer's Disease

    Akihiko Nunomura;George Perry;Miguel A. Pappolla;Ramon Wade

  • Automated banking machine system and method

    Mark D. Smith;Atta Mateen;David E. Kolinski-Schultz;Dale H. Blackson

  • Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

    Paula I. Moreira;Cristina Carvalho;Xiongwei Zhu;Mark A. Smith

  • Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease

    Lawrence M. Sayre;Mark A. Smith;George Perry

  • Involvement of Oxidative Stress in Alzheimer Disease

    Akihiko Nunomura;Rudy J. Castellani;Xiongwei Zhu;Paula I. Moreira

  • Mitochondrial Abnormalities in Alzheimer Disease

    G Perry;X Wang;M Smith;X Zhu

Frequent Co-Authors

George Perry
George Perry The University of Texas at San Antonio
Xiongwei Zhu
Xiongwei Zhu Case Western Reserve University
Paula I. Moreira
Paula I. Moreira University of Coimbra
Akihiko Nunomura
Akihiko Nunomura Jikei University School of Medicine
Xinglong Wang
Xinglong Wang University of Arizona
Lawrence M. Sayre
Lawrence M. Sayre Case Western Reserve University
Robert B. Petersen
Robert B. Petersen Case Western Reserve University
Robert P. Friedland
Robert P. Friedland University of Louisville
Jesús Avila
Jesús Avila Centro de Biología Molecular Severo Ochoa
Joseph C. LaManna
Joseph C. LaManna Case Western Reserve University

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