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D. Allan Butterfield

D. Allan Butterfield

D-Index & Metrics

Biology and Biochemistry

D-Index
151
Citations
71929
World Ranking
175
National Ranking
122

Overview

D. Allan Butterfield is a researcher affiliated with the University of Kentucky in the United States. Their work spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology, with significant contributions in the study of neurodegenerative diseases and molecular mechanisms related to brain health.

The primary focus areas of Butterfield's research include Alzheimer's disease research and treatments, extracellular vesicles in disease, mitochondrial function and pathology, biochemical effects in animals, down syndrome and intellectual disability research, cholinesterase and neurodegenerative diseases, and heme oxygenase-1 and carbon monoxide.

Their publications have appeared predominantly in several key scientific venues. The most frequent publication venues include Free Radical Biology and Medicine, Antioxidants, Neurobiology of Disease, Alzheimer's & Dementia, and Analytical and Bioanalytical Chemistry.

Butterfield's recent papers include:

  • "Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease" (2020, Neurobiology of Disease)
  • "Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease" (2023, Physiological Reviews)
  • "The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease" (2021, Free Radical Biology and Medicine)
  • "Insufficient Sun Exposure Has Become a Real Public Health Problem" (2020, International Journal of Environmental Research and Public Health)
  • "mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder" (2021, Free Radical Biology and Medicine)

Butterfield frequently collaborated with several coauthors over their career, which include Marzia Perluigi, Fabio Di Domenico, Luksana Chaiswing, Eugenio Barone, and Subbarao Bondada. These collaborations have contributed to advancing research in oxidative stress, neurodegeneration, and molecular biology related to neurodegenerative disorders.

Their expertise covers several subfields such as molecular biology, physiology, public health, environmental and occupational health, neurology, and pharmacology, reflecting a multidisciplinary approach to understanding disease mechanisms and potential interventions.

Best Publications

  • Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

    Vittorio Calabrese;Cesare Mancuso;Menotti Calvani;Enrico Rizzarelli

  • Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

    D.Allan Butterfield;Jennifer Drake;Chava Pocernich;Alessandra Castegna

  • Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

    D Allan Butterfield;Barry Halliwell

  • Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress.

    D.Allan Butterfield;Christopher M. Lauderback

  • Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

    D Allan Butterfield

  • Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity.

    Sridhar Varadarajan;Servet Yatin;Marina Aksenova;D.Allan Butterfield

  • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

    D Allan Butterfield;Alessandra Castegna;Christopher M Lauderback;Jennifer Drake

  • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

    Alessandra Castegna;Michael Aksenov;Marina Aksenova;Visith Thongboonkerd

  • Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

    D. Allan Butterfield;Tanea Reed;Shelley F. Newman;Rukhsana Sultana

  • Proteomic identification of nitrated proteins in Alzheimer's disease brain.

    Alessandra Castegna;Visith Thongboonkerd;Jon B. Klein;Bert Lynn

  • Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies.

    Jaroslaw Kanski;Marina Aksenova;Antonia Stoyanova;D.Allan Butterfield

  • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Aβ1–42

    Christopher M. Lauderback;Janna M. Hackett;Feng F. Huang;Jeffrey N. Keller

  • Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

    D. Allan Butterfield;Aaron M. Swomley;Rukhsana Sultana

  • Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.

    D.Allan Butterfield;Jaroslaw Kanski

  • The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.

    Susan A. Farr;Susan A. Farr;H. Fai Poon;Dilek Dogrukol-Ak;Jeniffer Drake

  • Nutritional approaches to combat oxidative stress in Alzheimer's disease.

    D.Allan Butterfield;Alessandra Castegna;Chava B. Pocernich;Jennifer Drake

  • Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

    Vittorio Calabrese;Raffaele Lodi;Caterina Tonon;Velia D'Agata

  • Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.

    Rukhsana Sultana;Marzia Perluigi;D. Allan Butterfield

  • Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues.

    Yumin Chen;Paiboon Jungsuwadee;Mary Vore;D. Allan Butterfield

  • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

    S M Yatin;S Varadarajan;C D Link;D A Butterfield

Frequent Co-Authors

Daret K. St. Clair
Daret K. St. Clair University of Kentucky
William M. Pierce
William M. Pierce University of Louisville
William R. Markesbery
William R. Markesbery University of Kentucky
Jon B. Klein
Jon B. Klein University of Louisville
Vittorio Calabrese
Vittorio Calabrese University of Catania
Elizabeth Head
Elizabeth Head University of California, Irvine
William A. Banks
William A. Banks University of Washington
John E. Morley
John E. Morley Saint Louis University
Giovanni Scapagnini
Giovanni Scapagnini University of Molise
Jason M. Unrine
Jason M. Unrine University of Kentucky

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