World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
24106
World Ranking
4276
National Ranking
2090

Overview

Jon B. Klein is affiliated with the University of Louisville in the United States and has a research background primarily anchored in the field of Medicine. Their work extensively covers multiple subfields including Nephrology, Molecular Biology, Genetics, Endocrinology, Diabetes and Metabolism, as well as Pulmonary and Respiratory Medicine.

The scientist's main research topics reflect an emphasis on understanding and investigating Renal Diseases and Glomerulopathies, which dominate their portfolio. Other significant areas of study include Chronic Kidney Disease and Diabetes, Ion Transport and Channel Regulation, Amyloidosis in terms of diagnosis, treatment, and outcomes, Cell Adhesion Molecules, advanced proteomics techniques and their applications, and the role of extracellular vesicles in disease.

Their recent published papers illustrate focused work within nephrology and related disciplines. These include:

  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes, 2021, Nature Communications
  • Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy, 2021, Journal of the American Society of Nephrology
  • Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis, 2020, Journal of the American Society of Nephrology
  • Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers, 2020, Oncotarget
  • Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease, 2022, American Journal of Kidney Diseases

Jon B. Klein frequently publishes in several scientific venues, notably:

  • Journal of the American Society of Nephrology
  • American Journal of Kidney Diseases
  • Kidney International Reports
  • Scientific Reports
  • Glomerular Diseases

The scientist collaborates with several frequent co-authors including:

  • Michael L. Merchant
  • Timothy D. Cummins
  • William E. Smoyer
  • Daniel W. Wilkey
  • Michelle T. Barati

Throughout their career, Jon B. Klein has concentrated on integrating molecular biology techniques with clinical nephrology, emphasizing proteomics and extracellular vesicles to better understand kidney-related diseases and possible biomarker identification.

Best Publications

  • M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.

    Laurence H. Beck;Ramon G.B. Bonegio;Gérard Lambeau;David M. Beck

  • Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

    Nicola M Tomas;Laurence H Beck;Catherine Meyer-Schwesinger;Barbara Seitz-Polski

  • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.

    Alessandra Castegna;Michael Aksenov;Visith Thongboonkerd;Jon B. Klein

  • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

    Alessandra Castegna;Michael Aksenov;Marina Aksenova;Visith Thongboonkerd

  • Proteomic identification of nitrated proteins in Alzheimer's disease brain.

    Alessandra Castegna;Visith Thongboonkerd;Jon B. Klein;Bert Lynn

  • Heat shock protein 27 controls apoptosis by regulating Akt activation.

    Madhavi J. Rane;Yong Pan;Saurabh Singh;David W. Powell

  • Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation

    Visith Thongboonkerd;Kenneth R. Mcleish;Kenneth R. Mcleish;Kenneth R. Mcleish;John M. Arthur;John M. Arthur;John M. Arthur;Jon B. Klein;Jon B. Klein;Jon B. Klein

  • Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

    D. Allan Butterfield;H. Fai Poon;Daret St. Clair;Jeffery N. Keller

  • Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach.

    Rukhsana Sultana;H. Fai Poon;Jian Cai;William M. Pierce

  • Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

    Michael L. Merchant;Ilse M. Rood;Jeroen K. J. Deegens;Jon B. Klein;Jon B. Klein

  • Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.

    Rukhsana Sultana;Debra Boyd-Kimball;H. Fai Poon;Jian Cai

  • Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways

    Jon B. Klein;Madhavi J. Rane;Janice A. Scherzer;Patricia Y. Coxon

  • Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

    Harald Mischak;Guenter Allmaier;Rolf Apweiler;Teresa Attwood

  • Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.

    Tanea Reed;Marzia Perluigi;Marzia Perluigi;Rukhsana Sultana;William M. Pierce

  • Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

    Marcus G. Pezzolesi;G. David Poznik;Josyf C. Mychaleckyj;Andrew D. Paterson

  • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.

    Madhavi J. Rane;Patricia Y. Coxon;Dave W. Powell;Rose Webster

  • Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

    Xia Shen;Shirong Zheng;Visith Thongboonkerd;Ming Xu

  • Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis

    Rukhsana Sultana;Debra Boyd-Kimball;H. Fai Poon;Jain Cai

  • AGRO100 inhibits activation of nuclear factor-κB (NF-κB) by forming a complex with NF-κB essential modulator (NEMO) and nucleolin

    Allicia C. Girvan;Yun Teng;Lavona K. Casson;Shelia D. Thomas

  • Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome

    Ilse M. Rood;Jeroen K.J. Deegens;Michael L. Merchant;Wim P.M. Tamboer

Frequent Co-Authors

Kenneth R. McLeish
Kenneth R. McLeish University of Louisville
William M. Pierce
William M. Pierce University of Louisville
D. Allan Butterfield
D. Allan Butterfield University of Kentucky
Visith Thongboonkerd
Visith Thongboonkerd Mahidol University
Brad H. Rovin
Brad H. Rovin The Ohio State University
William R. Markesbery
William R. Markesbery University of Kentucky
David Gozal
David Gozal Marshall University
John B. Harley
John B. Harley United States Department of Veterans Affairs
Gerald Sonnenfeld
Gerald Sonnenfeld Binghamton University
Christopher J. O'Donnell
Christopher J. O'Donnell Harvard Medical School

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