His primary areas of investigation include Kinase, Cell biology, MAPK/ERK pathway, Phosphorylation and Protein kinase B. Kenneth R. McLeish focuses mostly in the field of Kinase, narrowing it down to matters related to Respiratory burst and, in some cases, NADPH oxidase. His research in Cell biology intersects with topics in Exocytosis and Cytoskeleton.
His research investigates the connection with MAPK/ERK pathway and areas like LY294002 which intersect with concerns in Phagocytosis, Calphostin C and Leukotriene B4. In most of his Phosphorylation studies, his work intersects topics such as PI3K/AKT/mTOR pathway. Kenneth R. McLeish usually deals with Protein kinase B and limits it to topics linked to Molecular biology and AKT1 and Phosphatidylinositol.
His scientific interests lie mostly in Cell biology, Kinase, Biochemistry, Immunology and Respiratory burst. His Cell biology research includes elements of Exocytosis and Receptor. Kenneth R. McLeish studied Kinase and Phosphorylation that intersect with Molecular biology.
His work in the fields of Biochemistry, such as G protein, Intracellular and Membrane protein, overlaps with other areas such as Peptide mass fingerprinting. As a part of the same scientific family, Kenneth R. McLeish mostly works in the field of Membrane protein, focusing on Polyacrylamide gel electrophoresis and, on occasion, Proteome. His Respiratory burst research is multidisciplinary, relying on both NADPH oxidase, Endocrinology, Internal medicine, Priming and Superoxide.
Kenneth R. McLeish mainly focuses on Immunology, Inflammation, Cell biology, Glomerulonephritis and Exocytosis. His research integrates issues of Bronchoalveolar lavage and Coagulopathy in his study of Immunology. His research on Cell biology frequently connects to adjacent areas such as Priming.
His Priming research is multidisciplinary, incorporating perspectives in Respiratory burst, NADPH oxidase, Azurophilic granule and Actin cytoskeleton. While the research belongs to areas of Glomerulonephritis, Kenneth R. McLeish spends his time largely on the problem of Podocyte, intersecting his research to questions surrounding Pathology, Bone marrow, Nephritis and Tumor necrosis factor alpha. He has included themes like Granule, Specific granule, Protein kinase C, MARCKS and Animal data in his Exocytosis study.
Kenneth R. McLeish spends much of his time researching Cell biology, Priming, Immunology, Exocytosis and Actin cytoskeleton. The Cell biology study combines topics in areas such as Chemokine, Innate immune system, Chemotaxis and Respiratory burst. Kenneth R. McLeish interconnects Reactive oxygen species and Phagocytosis in the investigation of issues within Priming.
His Exocytosis research includes themes of Protein kinase C, MARCKS, Azurophilic granule and Specific granule.
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Heat shock protein 27 controls apoptosis by regulating Akt activation.
Madhavi J. Rane;Yong Pan;Saurabh Singh;David W. Powell.
Journal of Biological Chemistry (2003)
Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
Visith Thongboonkerd;Kenneth R. Mcleish;Kenneth R. Mcleish;Kenneth R. Mcleish;John M. Arthur;John M. Arthur;John M. Arthur;Jon B. Klein;Jon B. Klein;Jon B. Klein.
Kidney International (2002)
Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways
Jon B. Klein;Madhavi J. Rane;Janice A. Scherzer;Patricia Y. Coxon.
Journal of Immunology (2000)
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.
Madhavi J. Rane;Patricia Y. Coxon;Dave W. Powell;Rose Webster.
Journal of Biological Chemistry (2001)
Akt Phosphorylates p47phox and Mediates Respiratory Burst Activity in Human Neutrophils
Qingdan Chen;David W. Powell;Madhavi J. Rane;Saurabh Singh.
Journal of Immunology (2003)
Antibacterial effect of microvesicles released from human neutrophilic granulocytes.
Csaba I. Timár;Ákos M. Lőrincz;Roland Csépányi-Kömi;Anna Vályi-Nagy.
Blood (2013)
Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules.
Richard A. Ward;Michio Nakamura;Kenneth R. McLeish;Kenneth R. McLeish.
Journal of Biological Chemistry (2000)
Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF.
Kenneth R. McLeish;Kenneth R. McLeish;Cindy Knall;Richard A. Ward;Par Gerwins.
Journal of Leukocyte Biology (1998)
Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding
David W. Powell;Madhavi J. Rane;Brian A. Joughin;Ralitsa Kalmukova.
Molecular and Cellular Biology (2003)
Alterations in the Renal Elastin-Elastase System in Type 1 Diabetic Nephropathy Identified by Proteomic Analysis
Visith Thongboonkerd;Michelle T Barati;Kenneth R McLeish;Charaf Benarafa.
Journal of The American Society of Nephrology (2004)
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