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Biology and Biochemistry

D-Index
47
Citations
8189
World Ranking
18702
National Ranking
7646

Overview

Kenneth R. McLeish is affiliated with the University of Louisville in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on subfields including Immunology, Immunology and Allergy, Infectious Diseases, Nephrology, and Molecular Biology.

Their recent publications explore various aspects of immune response, inflammation, and renal diseases, reflecting key topics of interest such as Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Cell Adhesion Molecules Research, COVID-19 Clinical Research Studies, Renal Diseases and Glomerulopathies, Immune Response and Inflammation, Long-Term Effects of COVID-19, and Chronic Kidney Disease and Diabetes.

Notable recent papers include:

  • "A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients" (2021, JCI Insight)
  • "Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions" (2020, Journal of Leukocyte Biology)
  • "Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis" (2020, Journal of the American Society of Nephrology)
  • "Therapeutic targeting of neutrophil exocytosis" (2020, Journal of Leukocyte Biology)
  • "The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release" (2021, Frontiers in Immunology)

Kenneth R. McLeish frequently collaborates with several researchers, including Michael L. Merchant, Michelle T. Barati, Xiao Hu, Jiapeng Huang, and Jun Yan. These collaborations have resulted in multiple joint publications, demonstrating active engagement within their research community.

Publications are often found in specialized journals that align with their research interests. Frequent publication venues include:

  • Journal of the American Society of Nephrology
  • Frontiers in Immunology
  • Journal of Leukocyte Biology
  • JCI Insight
  • Immunological Reviews

Best Publications

  • Heat shock protein 27 controls apoptosis by regulating Akt activation.

    Madhavi J. Rane;Yong Pan;Saurabh Singh;David W. Powell

  • Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation

    Visith Thongboonkerd;Kenneth R. Mcleish;Kenneth R. Mcleish;Kenneth R. Mcleish;John M. Arthur;John M. Arthur;John M. Arthur;Jon B. Klein;Jon B. Klein;Jon B. Klein

  • Proteomic analysis of human neutrophil granules.

    George Lominadze;David W. Powell;Greg C. Luerman;Andrew J. Link

  • Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways

    Jon B. Klein;Madhavi J. Rane;Janice A. Scherzer;Patricia Y. Coxon

  • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.

    Madhavi J. Rane;Patricia Y. Coxon;Dave W. Powell;Rose Webster

  • Akt Phosphorylates p47phox and Mediates Respiratory Burst Activity in Human Neutrophils

    Qingdan Chen;David W. Powell;Madhavi J. Rane;Saurabh Singh

  • Antibacterial effect of microvesicles released from human neutrophilic granulocytes.

    Csaba I. Timár;Ákos M. Lőrincz;Roland Csépányi-Kömi;Anna Vályi-Nagy

  • Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules.

    Richard A. Ward;Michio Nakamura;Kenneth R. McLeish;Kenneth R. McLeish

  • Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF.

    Kenneth R. McLeish;Kenneth R. McLeish;Cindy Knall;Richard A. Ward;Par Gerwins

  • Multiple Phenotypic Changes Define Neutrophil Priming.

    Irina Miralda;Silvia M. Uriarte;Kenneth R. McLeish;Kenneth R. McLeish

  • Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding

    David W. Powell;Madhavi J. Rane;Brian A. Joughin;Ralitsa Kalmukova

  • The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets

    Neelakshi R. Jog;Madhavi J. Rane;George Lominadze;Gregory C. Luerman

  • Alterations in the Renal Elastin-Elastase System in Type 1 Diabetic Nephropathy Identified by Proteomic Analysis

    Visith Thongboonkerd;Michelle T Barati;Kenneth R McLeish;Charaf Benarafa

  • Identification of 14-3-3ζ as a Protein Kinase B/Akt Substrate

    David W. Powell;Madhavi J. Rane;Qingdan Chen;Saurabh Singh

  • Oxidant stress in hemodialysis patients: what are the determining factors?

    Richard A. Ward;Kenneth R. McLeish

  • Polymorphonuclear leukocyte oxidative burst is enhanced in patients with chronic renal insufficiency.

    Richard A. Ward;Kenneth R. McLeish

  • Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils.

    Kenneth R. McLeish;Jon B. Klein;Jon B. Klein;Patricia Y. Coxon;Kimberly Z. Head

  • Comparison of proteins expressed on secretory vesicle membranes and plasma membranes of human neutrophils.

    Silvia M. Uriarte;David W. Powell;Gregory C. Luerman;Michael L. Merchant

  • Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst.

    Silvia M. Uriarte;Madhavi J. Rane;Gregory C. Luerman;Michelle T. Barati

  • Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury.

    Michael M Schissler;Syed Zaidi;Haresh Kumar;Datinder Deo

Frequent Co-Authors

Jon B. Klein
Jon B. Klein University of Louisville
Visith Thongboonkerd
Visith Thongboonkerd Mahidol University
William M. Pierce
William M. Pierce University of Louisville
Gerald Sonnenfeld
Gerald Sonnenfeld Binghamton University
John B. Harley
John B. Harley United States Department of Veterans Affairs
Alex B. Lentsch
Alex B. Lentsch University of Cincinnati
Brad H. Rovin
Brad H. Rovin The Ohio State University
Martha K. Cathcart
Martha K. Cathcart Cleveland Clinic Lerner College of Medicine
William M. Nauseef
William M. Nauseef University of Iowa
Lee-Ann H. Allen
Lee-Ann H. Allen University of Iowa

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