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János G. Filep

János G. Filep

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
13645
World Ranking
6089
National Ranking
216

Overview

János G. Filep is affiliated with the University of Montreal in Canada and has contributed extensively to the fields of medicine, immunology, and molecular biology. Their research focuses particularly on immune response and inflammation, neutrophil, myeloperoxidase and oxidative mechanisms, as well as immune cells in cancer.

Their recent publications cover a range of topics related to inflammation and immune system regulation. Notable works include:

  • The Atlas of Inflammation Resolution (2020, Molecular Aspects of Medicine)
  • Roles of neutrophil granule proteins in orchestrating inflammation and immunity (2021, FEBS Journal)
  • C-reactive protein: a target for therapy to reduce inflammation (2023, Frontiers in Immunology)
  • Targeting Neutrophils for Promoting the Resolution of Inflammation (2022, Frontiers in Immunology)
  • 15-Epi-LXA 4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation (2020, Proceedings of the National Academy of Sciences)

Their work is published frequently in:

  • Journal of the American Society of Nephrology
  • Frontiers in Immunology
  • Molecular Aspects of Medicine
  • Proceedings of the National Academy of Sciences
  • Antioxidants

János G. Filep has collaborated regularly with several co-authors, including:

  • Kana N. Miyata
  • Julie R. Ingelfinger
  • John S.D. Chan
  • Shuiling Zhao
  • Junzheng Peng

Their research integrates several subfields such as immunology, molecular biology, endocrinology, diabetes and metabolism, epidemiology, and surgery. Key topics addressed encompass immune response and inflammation, neutrophil activity and oxidative mechanisms, immune cells in cancer, adipokines in inflammation and metabolic diseases, inflammasome and immune disorders, diabetes treatment and management, and genomics alongside oxidative stress related to phytochemicals.

Best Publications

  • Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells.

    Tarek Khreiss;Levente József;Lawrence A. Potempa;János G. Filep

  • Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes

    Levente József;Christine Zouki;Nicos A. Petasis;Charles N. Serhan

  • C-reactive protein and inflammation: conformational changes affect function.

    Wu Y;Potempa La;El Kebir D;Filep Jg

  • High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells

    Tusty-Jiuan Hsieh;Shao-Ling Zhang;Janos G. Filep;Shiow-Shih Tang

  • Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells

    Marie-Luise Brezniceanu;Fang Liu;Chih-Chang Wei;Isabelle Chénier

  • Prevention of In vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein.

    C Zouki;M Beauchamp;C Baron;J G Filep

  • 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.

    Driss El Kebir;Levente József;Wanling Pan;Lili Wang

  • Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation

    Driss El Kebir;Levente József;Wanling Pan;János G. Filep

  • Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice

    M.-L. Brezniceanu;F. Liu;C.-C. Wei;S. Tran

  • Glucocorticoid Receptor Regulates Expression of L-Selectin and CD11/CD18 on Human Neutrophils

    János G. Filep;Aline Delalandre;Yves Payette;Éva Földes-Filep

  • Loss of pentameric symmetry of C-reactive protein is associated with delayed apoptosis of human neutrophils.

    Tarek Khreiss;Levente József;Shireen Hossain;John S.D. Chan

  • Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ETA receptors and platelet-activating factor

    Christine Zouki;Chantal Baron;Alain Fournier;János G Filep

  • Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor

    A. Marilise Marrache;Fernand Gobeil;Sylvie G. Bernier;Jana Stankova

  • RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.

    S. Sachetelli;Q. Liu;S.-L. Zhang;F. Liu

  • Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1–32]

    Carlos Fernandez-Patron;Christine Zouki;Randy Whittal;John S. D. Chan

  • Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation

    Driss El Kebir;Levente József;Tarek Khreiss;Wanling Pan

  • Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains

    Shang-Rong Ji;Le Ma;Cai-Juan Bai;Jing-Ming Shi

  • Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.

    János G. Filep;Martin G. Sirois;Anne Rousseau;Alain Fournier

  • Loss of Pentameric Symmetry in C-Reactive Protein Induces Interleukin-8 Secretion Through Peroxynitrite Signaling in Human Neutrophils

    Tarek Khreiss;Levente József;Lawrence A. Potempa;János G. Filep

  • Acute pro‐inflammatory actions of endothelin‐1 in the guinea‐pig lung: involvement of ETA and ETB receptors

    János G. Filep;Alain Fournier;Éva Földes-Filep

Frequent Co-Authors

Julie R. Ingelfinger
Julie R. Ingelfinger Harvard University
Charles N. Serhan
Charles N. Serhan Brigham and Women's Hospital
Alain Fournier
Alain Fournier Institut National de la Recherche Scientifique
Nicos A. Petasis
Nicos A. Petasis University of Southern California
Olaf Wolkenhauer
Olaf Wolkenhauer University of Rostock
Oliver Soehnlein
Oliver Soehnlein University of Münster
Takao Shimizu
Takao Shimizu University of Tokyo
Catherine Godson
Catherine Godson University College Dublin
Jesper Z. Haeggström
Jesper Z. Haeggström Karolinska Institute
Angelo Azzi
Angelo Azzi Tufts University

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