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Takao Shimizu

Takao Shimizu

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
119
Citations
57129
World Ranking
667
National Ranking
28

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Takao Shimizu is affiliated with the University of Tokyo in Japan and has a research focus that spans biochemistry, genetics, molecular biology, and medicine. Their scholarly work encompasses molecular biology, physiology, biochemistry, spectroscopy, and cognitive neuroscience. The scientist's research contributes notably to areas such as lipid metabolism and biosynthesis, metabolomics and mass spectrometry studies, sphingolipid metabolism and signaling, lipid membrane structure and behavior, receptor mechanisms and signaling, asthma and respiratory diseases, and pain mechanisms and treatments.

Shimizu has published extensively, with significant appearances in venues like bioRxiv (Cold Spring Harbor Laboratory), IUPHAR/BPS Guide to Pharmacology CITE, The FASEB Journal, Journal of Biological Chemistry, and Metabolites. Their published articles include:

  • The Atlas of Inflammation Resolution (2020, Molecular Aspects of Medicine)
  • Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids (2020, iScience)
  • Raman microscopy-based quantification of the physical properties of intracellular lipids (2021, Communications Biology)
  • Lysophosphatidic acid, a simple phospholipid with myriad functions (2023, Pharmacology & Therapeutics)
  • Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment (2021, iScience)

The scientist frequently collaborates with several co-authors, including Hideo Shindou, Fumie Hamano, Yoshihiro Kita, Suzumi M. Tokuoka, and Tomomi Hashidate-Yoshida. This network signals interdisciplinary cooperation within their research community.

Shimizu's main areas of investigation are centered on lipid metabolism and biosynthesis, which informs a broader understanding of cell signaling and metabolic processes. Other notable topics include metabolomics and mass spectrometry studies, which are critical for analyzing molecular profiles in biological systems. Their work also addresses the biochemistry of sphingolipids and lipid membrane structure, linking molecular composition to physiological functions.

Their research encompasses receptor mechanisms and signaling pathways, contributing knowledge relevant to disorders such as asthma and various respiratory diseases. Pain mechanisms and treatments also form part of their investigative scope, blending molecular insights with clinical relevance.

Best Publications

  • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

    Toshimasa Yamauchi;Junji Kamon;Yusuke Ito;Atsushi Tsuchida

  • A comprehensive classification system for lipids

    Eoin Fahy;Shankar Subramaniam;H. Alex Brown;Christopher K. Glass

  • Update of the LIPID MAPS comprehensive classification system for lipids

    Eoin Fahy;Shankar Subramaniam;Robert C. Murphy;Masahiro Nishijima

  • A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.

    Takehiko Yokomizo;Takashi Izumi;Kyungho Chang;Yoh Takuwa

  • Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

    Masato Iwabu;Toshimasa Yamauchi;Miki Okada-Iwabu;Koji Sato

  • Role of cytosolic phospholipase A2 in allergic response and parturition.

    Naonori Uozumi;Kazuhiko Kume;Takahide Nagase;Noriaki Nakatani

  • Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

    Zen-ichiro Honda;Motonao Nakamura;Ichiro Miki;Michiko Minami

  • Arachidonic acid cascade and signal transduction.

    Takao Shimizu;Leonhard S. Wolfe

  • A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.

    Takehiko Yokomizo;Kazuhiko Kato;Kan Terawaki;Takashi Izumi

  • Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family *

    Kyoko Noguchi;Satoshi Ishii;Takao Shimizu

  • Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

    Takao Shimizu

  • The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo

    Nan Chiang;Charles N. Serhan;Sven-Erik Dahlén;Jeffrey M. Drazen

  • Acyl-CoA:lysophospholipid acyltransferases.

    Hideo Shindou;Takao Shimizu

  • Stabilizing the ferroelectric phase in doped hafnium oxide

    M. Hoffmann;U. Schroeder;T. Schenk;T. Shimizu

  • The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

    Asami Tanimura;Maya Yamazaki;Yuki Hashimotodani;Motokazu Uchigashima

  • Selective production of organic acids in anaerobic acid reactor by pH control.

    J.-I Horiuchi;T Shimizu;K Tada;T Kanno

  • Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.

    Satoshi Ishii;Takao Shimizu

  • Indoleamine 2,3-dioxygenase. Purification and some properties.

    T Shimizu;S Nomiyama;F Hirata;O Hayaishi

  • Basophils Play a Pivotal Role in Immunoglobulin-G-Mediated but Not Immunoglobulin-E-Mediated Systemic Anaphylaxis

    Yusuke Tsujimura;Kazushige Obata;Kaori Mukai;Hideo Shindou

  • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR

    K. Ito;H. Suzuki;T. Hirohashi;K. Kume

Frequent Co-Authors

Takehiko Yokomizo
Takehiko Yokomizo Juntendo University
Satoshi Ishii
Satoshi Ishii Akita University
Kazuhiko Kume
Kazuhiko Kume Nagoya City University
Hiroshi Funakubo
Hiroshi Funakubo Tokyo Institute of Technology
Haruhiko Bito
Haruhiko Bito University of Tokyo
Ryo Taguchi
Ryo Taguchi University of Tokyo
Olof Rådmark
Olof Rådmark Karolinska Institute
Charles N. Serhan
Charles N. Serhan Brigham and Women's Hospital
Bengt Samuelsson
Bengt Samuelsson Karolinska Institute
Shuh Narumiya
Shuh Narumiya Kyoto University

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