World's Best Scientists 2026 revealed!
Junken Aoki

Junken Aoki

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
108
Citations
39523
World Ranking
1056
National Ranking
56

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Junken Aoki is affiliated with Tohoku University in Japan and has a research focus primarily in the fields of Biochemistry, Genetics, and Molecular Biology, along with Medicine. Their work spans several subfields including Molecular Biology, Physiology, Cell Biology, Immunology, and Cellular and Molecular Neuroscience.

The scientist's main research topics include:

  • Sphingolipid Metabolism and Signaling
  • Lipid Membrane Structure and Behavior
  • Receptor Mechanisms and Signaling
  • Protein Kinase Regulation and GTPase Signaling
  • Lipid Metabolism and Biosynthesis
  • Endoplasmic Reticulum Stress and Disease
  • Mass Spectrometry Techniques and Applications

Junken Aoki has published extensively, with notable recent papers including:

  • "Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures," 2020, Journal of Lipid Research
  • "Structure of SARS-CoV-2 membrane protein essential for virus assembly," 2022, Nature Communications
  • "Lysophospholipid Mediators in Health and Disease," 2021, Annual Review of Pathology Mechanisms of Disease
  • "Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs," 2020, Molecular Cell
  • "Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease," 2021, Kidney International

The scientist frequently collaborates with several co-authors, including Kuniyuki Kano, Asuka Inoue, Nozomu Kono, Makoto Kurano, and Yutaka Yatomi.

Their work is often published in venues such as:

  • Nature Communications
  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Lipid Research
  • The FASEB Journal

Best Publications

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.

    Makiko Umezu-Goto;Yasuhiro Kishi;Akitsu Taira;Kotaro Hama

  • Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

    Gerhard Liebisch;Eoin Fahy;Junken Aoki;Edward A. Dennis

  • LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing.

    Xiaoqin Ye;Kotaro Hama;James J. A. Contos;Brigitte Anliker

  • Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

    Thomas M. McIntyre;Aaron V. Pontsler;Adriana R. Silva;Andy St. Hilaire

  • Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.

    Kenichi Takahashi;Hiroyuki Nakanishi;Masako Miyahara;Kenji Mandai

  • Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

    Koji Bandoh;Junken Aoki;Hiroyuki Hosono;Susumu Kobayashi

  • Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

    Masayuki Tanaka;Shinichi Okudaira;Yasuhiro Kishi;Ryunosuke Ohkawa

  • Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

    Junken Aoki;Akitsu Taira;Yasukazu Takanezawa;Yasuhiro Kishi

  • Illuminating G-Protein-Coupling Selectivity of GPCRs.

    Asuka Inoue;Asuka Inoue;Francesco Raimondi;Francois Marie Ngako Kadji;Gurdeep Singh

  • Two pathways for lysophosphatidic acid production.

    Junken Aoki;Asuka Inoue;Asuka Inoue;Shinichi Okudaira;Shinichi Okudaira

  • TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

    Asuka Inoue;Jun Ishiguro;Hajime Kitamura;Naoaki Arima

  • Lack of beta-arrestin signaling in the absence of active G proteins

    Manuel Grundmann;Nicole Merten;Davide Malfacini;Asuka Inoue;Asuka Inoue

  • The experimental power of FR900359 to study Gq-regulated biological processes

    Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Mechanisms of lysophosphatidic acid production

    Junken Aoki

  • Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

    Thomas J. Cahill;Alex R.B. Thomsen;Jeffrey T. Tarrasch;Bianca Plouffe

  • The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

    Shigetomo Fukuhara;Szandor Simmons;Shunsuke Kawamura;Asuka Inoue

  • Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.

    Koji Bandoh;Junken Aoki;Akitsu Taira;Masafumi Tsujimoto

  • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

    Junken Aoki;Yasuhiro Kishi

Frequent Co-Authors

Asuka Inoue
Asuka Inoue Tohoku University
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
Yutaka Yatomi
Yutaka Yatomi University of Tokyo
Keizo Inoue
Keizo Inoue University of Tokyo
Osamu Nureki
Osamu Nureki University of Tokyo
Tomohiko Ohwada
Tomohiko Ohwada University of Tokyo
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Jerold Chun
Jerold Chun Sanford Burnham Prebys Medical Discovery Institute
Masayuki Miyasaka
Masayuki Miyasaka Osaka University
Masayuki Tanaka
Masayuki Tanaka National Institutes of Natural Sciences

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