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Osamu Nureki

Osamu Nureki

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
99
Citations
42879
World Ranking
1569
National Ranking
86

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Osamu Nureki is affiliated with the University of Tokyo in Japan. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, focusing extensively on Molecular Biology, Cellular and Molecular Neuroscience, Spectroscopy, Materials Chemistry, and Genetics.

Their work covers a variety of research topics including:

  • Receptor Mechanisms and Signaling
  • CRISPR and Genetic Engineering
  • Photoreceptor and Optogenetics Research
  • RNA and Protein Synthesis Mechanisms
  • Mass Spectrometry Techniques and Applications
  • Neuroscience and Neuropharmacology Research
  • Ion Channel Regulation and Function

Nureki has published in multiple venues with varying focus and scope. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Communications Biology
  • Molecular Cell

Some recent notable papers include:

  • Amplification-free RNA detection with CRISPR-Cas13, 2021, Communications Biology
  • Structural insights into tetraspanin CD9 function, 2020, Nature Communications
  • Base editors for simultaneous introduction of C-to-T and A-to-G mutations, 2020, Nature Biotechnology
  • Structure of the miniature type V-F CRISPR-Cas effector enzyme, 2020, Molecular Cell
  • Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine, 2022, Cell

Frequent collaborators in their research include:

  • Wataru Shihoya
  • Keitaro Yamashita
  • Tsukasa Kusakizako
  • Tomohiro Nishizawa
  • Fumiya K. Sano

Best Publications

  • Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

    Silvana Konermann;Mark D. Brigham;Alexandro E. Trevino;Julia Joung

  • Crystal structure of Cas9 in complex with guide RNA and target DNA

    Takashi Yamano;Hiroshi Nishimasu;Hiroshi Nishimasu;Bernd Zetsche;Hisato Hirano

  • Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

    Hideo Ogiso;Ryuichiro Ishitani;Osamu Nureki;Shuya Fukai

  • Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

    Hiroshi Nishimasu;Naoshi Dohmae;Ryuichiro Ishitani;Osamu Nureki

  • Engineered CRISPR-Cas9 nuclease with expanded targeting space

    Hiroshi Nishimasu;Xi Shi;Xi Shi;Soh Ishiguro;Soh Ishiguro;Linyi Gao;Linyi Gao

  • Integrated molecular analysis of adult T cell leukemia/lymphoma

    Keisuke Kataoka;Yasunobu Nagata;Akira Kitanaka;Yuichi Shiraishi

  • Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

    Mamiko Sakata-Yanagimoto;Terukazu Enami;Kenichi Yoshida;Yuichi Shiraishi

  • Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL.

    Michihiro Suga;Fusamichi Akita;Fusamichi Akita;Michihiro Sugahara;Minoru Kubo

  • Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa

    Toru Sengoku;Osamu Nureki;Akira Nakamura;Satoru Kobayashi

  • Crystal structure of the channelrhodopsin light-gated cation channel

    Hideaki E. Kato;Feng Zhang;Ofer Yizhar;Charu Ramakrishnan

  • Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein.

    Noriko Handa;Osamu Nureki;Kazuki Kurimoto;Insil Kim

  • A three-dimensional movie of structural changes in bacteriorhodopsin

    Eriko Nango;Antoine Royant;Antoine Royant;Minoru Kubo;Takanori Nakane

  • Enzyme structure with two catalytic sites for double-sieve selection of substrate.

    Osamu Nureki;Dmitry G. Vassylyev;Masaru Tateno;Atsushi Shimada

  • Crystal Structure of Staphylococcus aureus Cas9

    Hiroshi Nishimasu;Hiroshi Nishimasu;Le Cong;Winston X. Yan;F. Ann Ran;F. Ann Ran

  • Engineered Cpf1 variants with altered PAM specificities

    Linyi Gao;Linyi Gao;David B T Cox;David B T Cox;Winston X Yan;Winston X Yan;Winston X Yan;John C Manteiga

  • Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

    Yusuke Sato;Azusa Yoshikawa;Atsushi Yamagata;Hisatoshi Mimura

  • Structure and Engineering of Francisella novicida Cas9.

    Hisato Hirano;Jonathan S. Gootenberg;Takuro Horii;Omar O. Abudayyeh

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase.

    Shuya Fukai;Osamu Nureki;Shun ichi Sekine;Atsushi Shimada

  • Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

    Kazuki Kato;Hiroki Omura;Ryuichiro Ishitani;Osamu Nureki

Frequent Co-Authors

Ryuichiro Ishitani
Ryuichiro Ishitani University of Tokyo
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Junken Aoki
Junken Aoki Tohoku University
So Iwata
So Iwata Kyoto University
Hideki Kandori
Hideki Kandori Nagoya Institute of Technology
Mikako Shirouzu
Mikako Shirouzu RIKEN Center for Biosystems Dynamics Research
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo

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