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Hiroaki Suga

Hiroaki Suga

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
19215
World Ranking
5610
National Ranking
362

Overview

Hiroaki Suga is affiliated with the University of Tokyo in Japan. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant volume of work also related to the fields of medicine and molecular biology. Their scientific contributions span several key subfields including molecular biology, oncology, organic chemistry, pharmacology, and radiology, nuclear medicine, and imaging.

The main topics of Hiroaki Suga's research include:

  • Chemical Synthesis and Analysis
  • RNA and Protein Synthesis Mechanisms
  • Peptidase Inhibition and Analysis
  • Ubiquitin and Proteasome Pathways
  • Microbial Natural Products and Biosynthesis
  • Monoclonal and Polyclonal Antibodies Research
  • Click Chemistry and Applications

Hiroaki Suga has co-authored many publications with several frequent collaborators, including:

  • Yuki Goto
  • Takayuki Katoh
  • Alexander A. Vinogradov
  • Toby Passioura
  • Naohiro Terasaka

The scientist's body of work has been published repeatedly in several notable scientific venues, reflecting a focus on chemistry and molecular biology. Frequent publication venues include:

  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Angewandte Chemie International Edition
  • Nature Communications
  • Nucleic Acids Research

Recent publications by Hiroaki Suga demonstrate a focus on macrocyclic peptides, foldamer peptides, and cyclic peptide ligands, often combining synthetic and biological chemistry approaches. Selected recent papers include:

  • The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides, 2021, Accounts of Chemical Research
  • Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids, 2020, Nature Chemistry
  • GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf, 2020, ACS Central Science
  • Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming, 2020, Cell Chemical Biology
  • Ribosomal Elongation of Cyclic γ-Amino Acids using a Reprogrammed Genetic Code, 2020, Journal of the American Chemical Society

Best Publications

  • Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

    Alexander A Vinogradov;Yizhen Yin;Hiroaki Suga

  • A highly flexible tRNA acylation method for non-natural polypeptide synthesis.

    Hiroshi Murakami;Atsushi Ohta;Hiroshi Ashigai;Hiroaki Suga

  • Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs.

    Kristina M Smith;Yigong Bu;Hiroaki Suga;Hiroaki Suga

  • Flexizymes for genetic code reprogramming

    Yuki Goto;Takayuki Katoh;Hiroaki Suga;Hiroaki Suga

  • Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

    Yusuke Yamagishi;Ikuo Shoji;Shoji Miyagawa;Takashi Kawakami

  • Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides.

    Yuki Goto;Atsushi Ohta;Yusuke Sako;Yusuke Yamagishi

  • Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer

    Kristina M. Smith;Yigong Bu;Hiroaki Suga

  • Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.

    Jinwoo Kim;Jung-Gun Kim;Yongsung Kang;Ji Youn Jang

  • Ribozyme-catalyzed tRNA aminoacylation.

    Nick Lee;Yoshitaka Bessho;Kenneth Wei;Jack W. Szostak

  • Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

    Yoshiki Tanaka;Christopher J. Hipolito;Andrés D. Maturana;Koichi Ito

  • Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides.

    Takashi Kawakami;Hiroshi Murakami;Hiroaki Suga

  • RNA Display Methods for the Discovery of Bioactive Macrocycles

    Yichao Huang;Mareike Margarete Wiedmann;Hiroaki Suga

  • Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

    Atsushi Kodan;Tomohiro Yamaguchi;Toru Nakatsu;Keita Sakiyama

  • Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

    Jumpei Morimoto;Yuuki Hayashi;Hiroaki Suga

  • Selection-based discovery of druglike macrocyclic peptides.

    Toby Passioura;Takayuki Katoh;Yuki Goto;Hiroaki Suga

  • Diverse backbone-cyclized peptides via codon reprogramming

    Takashi Kawakami;Atsushi Ohta;Masaki Ohuchi;Hiroshi Ashigai

  • Molecular mechanisms of bacterial quorum sensing as a new drug target.

    Hiroaki Suga;Kristina M Smith

  • Synthesis of Polyester by Means of Genetic Code Reprogramming

    Atsushi Ohta;Hiroshi Murakami;Eri Higashimura;Hiroaki Suga

  • A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets

    Toby Passioura;Hiroaki Suga

  • An in vitro evolved precursor tRNA with aminoacylation activity.

    Hirohide Saito;Dimitrios Kourouklis;Hiroaki Suga

Frequent Co-Authors

Kevan M. Shokat
Kevan M. Shokat University of California, San Francisco
Osamu Nureki
Osamu Nureki University of Tokyo
Junichi Takagi
Junichi Takagi Osaka University
Karin Musier-Forsyth
Karin Musier-Forsyth The Ohio State University
Ivan Huc
Ivan Huc Ludwig-Maximilians-Universität München
Kunio Matsumoto
Kunio Matsumoto Kanazawa University
Craig M. Crews
Craig M. Crews Yale University
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Christian Hertweck
Christian Hertweck Friedrich Schiller University Jena

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