World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
64
Citations
12739
World Ranking
8150
National Ranking
2352

Biology and Biochemistry

D-Index
62
Citations
12472
World Ranking
10901
National Ranking
4725

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - Fellow of Alfred P. Sloan Foundation
  • 1961 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Helen E. Blackwell is affiliated with the University of Wisconsin-Madison in the United States. Their research activity is primarily situated in the field of Biochemistry, Genetics and Molecular Biology, with a total of 62 publications. Within this wider discipline, their work prominently intersects with subfields such as Molecular Biology, Genetics, Infectious Diseases, Surfaces, Coatings and Films, and Microbiology.

The scientist's research topics focus strongly on areas related to bacterial behavior and interactions. Key topics covered include:

  • Bacterial biofilms and quorum sensing
  • Bacterial Genetics and Biotechnology
  • Antimicrobial Resistance in Staphylococcus
  • Lipid Membrane Structure and Behavior
  • Antimicrobial Peptides and Activities
  • Antibiotic Resistance in Bacteria
  • Surface Modification and Superhydrophobicity

Frequent coauthors contributing to Helen E. Blackwell's publications include:

  • David M. Lynn (14 publications)
  • Daniel E. Manson (8 publications)
  • Thomas J. Polaske (7 publications)
  • Emma E. Santa (7 publications)
  • Kayleigh E. Nyffeler (7 publications)

The scientist regularly publishes in specific academic venues. These include:

  • ACS Infectious Diseases (6 publications)
  • ACS Chemical Biology (6 publications)
  • ACS Applied Materials & Interfaces (5 publications)
  • Langmuir (3 publications)
  • Nature Microbiology (2 publications)

Recent papers authored include the following:

  • Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut, 2023, Nature Microbiology
  • Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values, 2020, ACS Infectious Diseases
  • Liquid Crystal Emulsions That Intercept and Report on Bacterial Quorum Sensing, 2020, ACS Applied Materials & Interfaces
  • Slippery Antifouling Polymer Coatings Fabricated Entirely from Biodegradable and Biocompatible Components, 2022, ACS Applied Materials & Interfaces
  • Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor, 2020, ACS Infectious Diseases

Helen E. Blackwell has received several awards and honors during their career, including:

  • Fellow of the American Association for the Advancement of Science (AAAS) in 2010
  • Fellow of Alfred P. Sloan Foundation in 2006
  • Fellow of the American Association for the Advancement of Science (AAAS) in 1961

Best Publications

  • Highly Efficient Synthesis of Covalently Cross‐Linked Peptide Helices by Ring‐Closing Metathesis

    Helen E. Blackwell;Robert H. Grubbs

  • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.

    Christina M. Grozinger;Elizabeth D. Chao;Helen E. Blackwell;Danesh Moazed

  • New Approaches to Olefin Cross-Metathesis

    Helen E. Blackwell;‡ Daniel J. O'Leary;Arnab K. Chatterjee;Rebecca A. Washenfelder

  • Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation

    Grant D. Geske;Rachel J. Wezeman;and Adam P. Siegel;Helen E. Blackwell

  • Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

    Sarah A. Fowler;Helen E. Blackwell

  • Modulation of Bacterial Quorum Sensing with Synthetic Ligands: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanisms of Action

    Grant D Geske;Jennifer C O'Neill;David M Miller;Margrith E Mattmann

  • Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

    Grant D. Geske;Jennifer C. O’Neill;Helen E. Blackwell

  • Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides.

    Helen E. Blackwell;Jack D. Sadowsky;Rebecca J. Howard;Joshua N. Sampson

  • Local and Tunable n→π* Interactions Regulate Amide Isomerism in the Peptoid Backbone

    Benjamin C Gorske;Brent L Bastian;Grant D Geske;Helen E Blackwell

  • Self-assembly of taper-shaped monoesters of oligo(ethylene oxide) with 3,4,5-tris(n-dodecan-1-yloxy)benzoic acid and of their polymethacrylates into tubular supramolecular architectures displaying a columnar hexagonal mesophase

    Virgil Percec;James Heck;Dimitris Tomazos;Frederick Falkenberg

  • Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains

    Joseph R. Stringer;J. Aaron Crapster;Ilia A. Guzei;Helen E. Blackwell

  • New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems

    Benjamin C. Gorske;Joseph R. Stringer;Brent L. Bastian;Sarah A. Fowler

  • Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform

    David R. Spring;Shyam Krishnan;Helen E. Blackwell;Stuart L. Schreiber

  • SIR1, an upstream component in auxin signaling identified by chemical genetics.

    Yunde Zhao;Xinhua Dai;Helen E. Blackwell;Stuart L. Schreiber

  • Out of the oil bath and into the oven—microwave-assisted combinatorial chemistry heats up

    Helen E. Blackwell

  • 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms.

    Reto Frei;Anthony S. Breitbach;Helen E. Blackwell

  • Chemical genetic approaches to plant biology

    Helen E. Blackwell;Yunde Zhao

  • New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides.

    Jennifer Campbell;Qi Lin;Grant D Geske;Helen E Blackwell

  • Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes

    Michael A. Welsh;Nora R. Eibergen;Joseph D. Moore;Helen E. Blackwell

  • Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach

    Uttam Manna;Namrata Raman;Michael A. Welsh;Yashira M. Zayas-Gonzalez

  • Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis

    Robert H. Grubbs;J. Scott Miller;Helen E. Blackwell

Frequent Co-Authors

Robert H. Grubbs
Robert H. Grubbs California Institute of Technology
David M. Lynn
David M. Lynn University of Wisconsin–Madison
Michael Welsh
Michael Welsh Uppsala University
Ilia A. Guzei
Ilia A. Guzei University of Wisconsin–Madison
Rebecca A. Washenfelder
Rebecca A. Washenfelder National Oceanic and Atmospheric Administration
Bernard Weisblum
Bernard Weisblum University of Wisconsin–Madison
Michael Givskov
Michael Givskov University of Copenhagen
Yunde Zhao
Yunde Zhao University of California, San Diego
Alexander R. Horswill
Alexander R. Horswill University of Colorado Anschutz Medical Campus
Jo Handelsman
Jo Handelsman University of Wisconsin–Madison

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