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Biology and Biochemistry

D-Index
57
Citations
10273
World Ranking
13975
National Ranking
5903

Overview

Christian Melander is affiliated with the University of Notre Dame in the United States. Their research spans several interconnected areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, molecular medicine, pharmacology, epidemiology, and infectious diseases.

The scientist has contributed to a number of research topics, including:

  • Antibiotic Resistance in Bacteria
  • Bacterial biofilms and quorum sensing
  • Microbial Natural Products and Biosynthesis
  • Bacterial Genetics and Biotechnology
  • Cancer therapeutics and mechanisms
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Pneumocystis jirovecii pneumonia detection and treatment

Frequent publication venues for Christian Melander include:

  • ACS Infectious Diseases
  • Bioorganic & Medicinal Chemistry Letters
  • mBio
  • ChemMedChem
  • Antibiotics

Some of the recent published papers by Christian Melander are:

  • Natural products as inspiration for the development of bacterial antibiofilm agents, 2020, Natural Product Reports
  • Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections, 2023, Cell Reports
  • Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics, 2020, ACS Infectious Diseases
  • A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics, 2020, ACS Infectious Diseases
  • Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants, 2022, Bioorganic & Medicinal Chemistry Letters

Christian Melander has collaborated frequently with several coauthors, including:

  • Roberta J. Melander
  • Michael J. Zeiler
  • Anne E. Mattingly
  • Ansley M. Nemeth

Best Publications

  • Combination approaches to combat multidrug-resistant bacteria

    Roberta J. Worthington;Christian Melander

  • Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

    Mary Catherine Bowman;T. Eric Ballard;Christopher J. Ackerson;Daniel L. Feldheim

  • Small molecule control of bacterial biofilms

    Roberta J. Worthington;Justin J. Richards;Christian Melander

  • Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

    Steven A. Rogers;Robert W. Huigens;John Cavanagh;Christian Melander

  • Controlling bacterial biofilms.

    Justin J. Richards;Christian Melander

  • Overcoming Resistance to β-Lactam Antibiotics

    Roberta J. Worthington;Christian Melander

  • The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

    Roberta J. Melander;Christian Melander

  • Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands

    Robert K. Suto;Rajeswari S. Edayathumangalam;Cindy L. White;Christian Melander

  • Narrow-Spectrum Antibacterial Agents.

    Roberta J. Melander;Daniel V. Zurawski;Christian Melander

  • Inhibition of Pseudomonas aeruginosa Biofilm Formation with Bromoageliferin Analogues

    Robert W. Huigens;Justin J. Richards;Gina Parise;T. Eric Ballard

  • Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms.

    Justin J. Richards;T. Eric Ballard;Robert W. Huigens;Christian Melander

  • Sequence specific fluorescence detection of double strand DNA.

    Victor C. Rucker;Shane Foister;Christian Melander;Peter B. Dervan

  • Biologically inspired strategies for combating bacterial biofilms

    Meghan S Blackledge;Roberta J Worthington;Christian Melander

  • Construction and Screening of a 2‑Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum

    Steven A. Rogers;Christian Melander

  • Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.

    Joel M. Gottesfeld;Christian Melander;Christian Melander;Christian Melander;Robert K. Suto;Robert K. Suto;Robert K. Suto;Holger Raviol;Holger Raviol;Holger Raviol

  • DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia

    Ryan Burnett;Christian Melander;James W. Puckett;Leslie S. Son

  • Anti-Biofilm Compounds Derived from Marine Sponges

    Sean D. Stowe;Justin J. Richards;Ashley T. Tucker;Richele Thompson

  • Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

    Justin J. Richards;T. Eric Ballard;Christian Melander

  • Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

    Mark J. Kurth;Lisa A. Ahlberg Randall;Chixu Chen;Christian Melander

  • Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure–Activity Relationship Study

    T. Eric Ballard;Justin J. Richards;Amanda L. Wolfe;Christian Melander

Frequent Co-Authors

Peter B. Dervan
Peter B. Dervan California Institute of Technology
Joel M. Gottesfeld
Joel M. Gottesfeld Scripps Research Institute
Robert K. Ernst
Robert K. Ernst University of Maryland, Baltimore
Randall J. Basaraba
Randall J. Basaraba Colorado State University
David M. Margolis
David M. Margolis University of North Carolina at Chapel Hill
Karolin Luger
Karolin Luger University of Colorado Boulder
Beverly H. Koller
Beverly H. Koller University of North Carolina at Chapel Hill
Jonathan S. Lindsey
Jonathan S. Lindsey North Carolina State University
Wei Zeng
Wei Zeng South China University of Technology
John S. Gunn
John S. Gunn Nationwide Children's Hospital

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