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Molecular Biology

D-Index
82
Citations
41749
World Ranking
914
National Ranking
484

Research.com Recognitions

  • 2018 - Member of the National Academy of Sciences
  • 2017 - Fellow of the American Academy of Arts and Sciences

Overview

Karolin Luger is affiliated with the University of Colorado Boulder in the United States and has produced extensive research primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their scholarly output includes over 100 publications, with a strong focus on molecular biology and related subfields such as oncology, electrical and electronic engineering, genetics, and plant science.

The core topics in Luger's research portfolio encompass Genomics and Chromatin Dynamics, PARP inhibition in cancer therapy, RNA and protein synthesis mechanisms, DNA repair mechanisms, integrated circuits and semiconductor failure analysis, RNA modifications and cancer, and bacterial genetics and biotechnology.

Notable recent papers authored or coauthored by Karolin Luger include:

  • Inhibitors of PARP: Number crunching and structure gazing, 2022, Proceedings of the National Academy of Sciences
  • Virus-encoded histone doublets are essential and form nucleosome-like structures, 2021, Cell
  • The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer, 2021, Molecular Cell
  • HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase, 2021, eLife
  • Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs, 2021, Nature Communications

Luger collaborates frequently with several researchers, including Johannes Rudolph, Samuel Bowerman, Uma M. Muthurajan, Jyothi Mahadevan, and Keda Zhou, reflecting a network of partnerships across various domains of molecular and cellular biology.

Publication venues where Karolin Luger's work appears regularly include bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, eLife, Nature Communications, and Nature Microbiology. This distribution highlights interdisciplinary dissemination across both preprint and peer-reviewed journals in biophysics and molecular life sciences.

Recognitions awarded to Karolin Luger include election as a Member of the National Academy of Sciences in 2018 and as a Fellow of the American Academy of Arts and Sciences in 2017, indicating acknowledged contributions to their scientific disciplines.

Best Publications

  • Crystal structure of the nucleosome core particle at 2.8 Å resolution

    Karolin Luger;Armin W. Mäder;Robin K. Richmond;David F. Sargent

  • Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 Å Resolution

    Curt A. Davey;David F. Sargent;Karolin Luger;Armin W. Maeder

  • Preparation of nucleosome core particle from recombinant histones.

    Karolin Luger;Thomas J. Rechsteiner;Timothy J. Richmond

  • New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

    Karolin Luger;Mekonnen L. Dechassa;David J. Tremethick

  • Reconstitution of Nucleosome Core Particles from Recombinant Histones and DNA

    Pamela N. Dyer;Raji S. Edayathumangalam;Cindy L. White;Yunhe Bao

  • Crystal structure of a nucleosome core particle containing the variant histone H2A.Z

    Robert K. Suto;Michael J. Clarkson;David J. Tremethick;Karolin Luger

  • The histone tails of the nucleosome

    Karolin Luger;Timothy J Richmond

  • Characterization of nucleosome core particles containing histone proteins made in bacteria

    Karolin Luger;Thomas J Rechsteiner;Andrew J Flaus;Mary M.Y Waye

  • Expression and Purification of Recombinant Histones and Nucleosome Reconstitution

    Karolin Luger;Thomas J. Rechsteiner;Timothy J. Richmond

  • The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.

    Andrew J. Barbera;Jayanth V. Chodaparambil;Brenna Kelley-Clarke;Vladimir Joukov

  • Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions.

    Cindy L. White;Robert K. Suto;Karolin Luger

  • Structural determinants for generating centromeric chromatin

    Ben E. Black;Daniel R. Foltz;Daniel R. Foltz;Srinivas Chakravarthy;Karolin Luger

  • H2A.Z Alters the Nucleosome Surface to Promote HP1α-Mediated Chromatin Fiber Folding

    Jun Y. Fan;Danny Rangasamy;Karolin Luger;David J. Tremethick

  • DNA binding within the nucleosome core.

    Karolin Luger;Timothy J Richmond

  • Structure and dynamic behavior of nucleosomes.

    Karolin Luger

  • The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states

    Jun Y. Fan;Faye Gordon;Karolin Luger;Jeffrey C. Hansen

  • Nucleosome structure(s) and stability: variations on a theme.

    Andrew J Andrews;Karolin Luger

  • Nucleosome and chromatin fiber dynamics

    Karolin Luger;Jeffrey C Hansen

  • The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis

    Ramesh Yelagandula;Hume Stroud;Sarah Holec;Keda Zhou

  • Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo.

    Karolin Luger;Ulrich Hommel;Marzell Herold;Jan Hofsteenge

Frequent Co-Authors

Jeffrey C. Hansen
Jeffrey C. Hansen Colorado State University
Joel M. Gottesfeld
Joel M. Gottesfeld Scripps Research Institute
David J. Tremethick
David J. Tremethick Australian National University
Peter B. Dervan
Peter B. Dervan California Institute of Technology
Christian Melander
Christian Melander University of Notre Dame
Ben E. Black
Ben E. Black University of Pennsylvania
Simon E. V. Phillips
Simon E. V. Phillips University of Oxford
Jörg Langowski
Jörg Langowski German Cancer Research Center

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