Member of the European Molecular Biology Organization (EMBO)
Tom Owen-Hughes mostly deals with Chromatin, Nucleosome, Cell biology, Chromatin remodeling and Histone. Tom Owen-Hughes has begun a study into Chromatin, looking into Biochemistry and Genetics. His study on Nucleosome is covered under DNA.
His Cell biology research is multidisciplinary, incorporating perspectives in TAF1, Molecular biology, Histone acetyltransferase, Chromatin structure remodeling complex and Transcription factor II D. His studies examine the connections between Chromatin remodeling and genetics, as well as such issues in Regulation of gene expression, with regards to In vivo, Function, Therapeutic gene modulation, Gene product and DNA supercoil. His research integrates issues of CHD1L and Proliferating cell nuclear antigen in his study of Histone.
Tom Owen-Hughes focuses on Nucleosome, Chromatin, Cell biology, Histone and Chromatin remodeling. His work on Histone octamer and Histone code as part of general Nucleosome study is frequently connected to Histone methylation, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His Chromatin research entails a greater understanding of Genetics.
His research on Cell biology also deals with topics like
Tom Owen-Hughes mostly deals with Cell biology, Chromatin, Nucleosome, Histone and DNA. Cell biology is closely attributed to Chromatin remodeling in his research. His study on Nucleosome sliding is often connected to Asymmetry as part of broader study in Chromatin.
His Nucleosome research includes elements of Chromatin remodelling and Proliferating cell nuclear antigen. The study incorporates disciplines such as Biophysics, DNA replication and Gene isoform in addition to Histone. His research in DNA intersects with topics in ATPase and Ubiquitin.
His scientific interests lie mostly in Chromatin remodeling, Cell biology, Translation, Polysome and Protein biosynthesis. The Chromatin remodeling study combines topics in areas such as Structural biology, Regulation of gene expression and Nucleosome. His Cell biology study combines topics from a wide range of disciplines, such as Histone, Bromodomain, DNA, Myeloid leukemia and Ubiquitin ligase.
His studies deal with areas such as Size-exclusion chromatography, Ribosomal RNA, Amino acid and Proteomics as well as Translation.
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Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
P A Grant;L Duggan;J Côté;S M Roberts.
Genes & Development (1997)
The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity
Craig A. Mizzen;Xiang Jiao Yang;Tetsuro Kokubo;James E. Brownell.
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs
Andrew Flaus;David M. A. Martin;Geoffrey J. Barton;Tom Owen-Hughes.
Nucleic Acids Research (2006)
How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
Nicholas J. Schurch;Pietá Schofield;Marek Gierliński;Christian Cole.
Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes
Geeta J. Narlikar;Ramasubramanian Sundaramoorthy;Tom Owen-Hughes.
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo.
Evaluation of tools for differential gene expression analysis by RNA-seq on a 48 biological replicate experiment
Nicholas J. Schurch;Pieta Schofield;Marek Gierliński;Christian Cole.
arXiv: Genomics (2015)
A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation
Heinz Neumann;Susan M. Hancock;Ruth Buning;Andrew Routh.
Molecular Cell (2009)
Nucleosome mobilization catalysed by the yeast SWI/SNF complex
Iestyn Whitehouse;Andrew Flaus;Bradley R. Cairns;Malcolm F. White.
The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression.
Thomas A. Owen-Hughes;Graham D. Pavitt;Diogenes S. Santos;Julie M. Sidebotham.
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