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D-Index & Metrics

Molecular Biology

D-Index
66
Citations
17862
World Ranking
1612
National Ranking
125

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Tom Owen-Hughes is affiliated with the University of Dundee in the United Kingdom. Their research primarily centers on the fields of Biochemistry, Genetics, and Molecular Biology, with a particular focus on molecular biology as a subfield. Owen-Hughes' work encompasses various sub-disciplines such as pathology and forensic medicine, genetics, immunology, and plant science.

Their research topics include:

  • Genomics and Chromatin Dynamics
  • Chromatin Remodeling and Cancer
  • Cancer Mechanisms and Therapy
  • Epigenetics and DNA Methylation
  • DNA Repair Mechanisms
  • Mechanisms of cancer metastasis
  • RNA modifications and cancer

Owen-Hughes has contributed to several recent scientific papers. Notable publications include:

  • Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription, 2021, Cell Reports
  • Histone isoforms and the oncohistone code, 2020, Current Opinion in Genetics & Development
  • Proteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication, 2023, Cell Reports
  • Chromatin remodelling comes into focus, 2020, F1000Research
  • RNA polymerase II promotes the organization of chromatin following DNA replication, 2024, EMBO Reports

The scientist frequently collaborates with other researchers, including:

  • Ramasubramanian Sundaramoorthy
  • Vanesa Álvarez
  • Susanne Bandau
  • Hao Jiang
  • Angus I. Lamond

Owen-Hughes' work is often published in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Cell Reports
  • Current Opinion in Genetics & Development
  • F1000Research
  • EMBO Reports

They have been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

    P A Grant;L Duggan;J Côté;S M Roberts

  • The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

    Craig A. Mizzen;Xiang Jiao Yang;Tetsuro Kokubo;James E. Brownell

  • How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

    Nicholas J. Schurch;Pietá Schofield;Marek Gierliński;Christian Cole

  • Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

    Andrew Flaus;David M. A. Martin;Geoffrey J. Barton;Tom Owen-Hughes

  • Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

    Geeta J. Narlikar;Ramasubramanian Sundaramoorthy;Tom Owen-Hughes

  • Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

    Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo

  • A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

    Heinz Neumann;Susan M. Hancock;Ruth Buning;Andrew Routh

  • Evaluation of tools for differential gene expression analysis by RNA-seq on a 48 biological replicate experiment

    Nicholas J. Schurch;Pieta Schofield;Marek Gierliński;Christian Cole

  • BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.

    William Farnaby;Manfred Koegl;Michael J. Roy;Claire Whitworth

  • Nucleosome mobilization catalysed by the yeast SWI/SNF complex

    Iestyn Whitehouse;Andrew Flaus;Bradley R. Cairns;Malcolm F. White

  • The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression.

    Thomas A. Owen-Hughes;Graham D. Pavitt;Diogenes S. Santos;Julie M. Sidebotham

  • Histone-like protein H1 (H-NS), DNA supercoiling, and gene expression in bacteria

    Christopher S.J. Hulton;Alexander Seirafi;Jay C.D. Hinton;Julie M. Sidebotham

  • Generation of superhelical torsion by ATP-dependent chromatin remodeling activities.

    Kristina Havas;Andrew Flaus;Michael Phelan;Robert Kingston

  • A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization.

    Triantaffyllos Gkikopoulos;Pieta Schofield;Vijender Singh;Marina Pinskaya

  • Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex

    T. Owen-Hughes;R. T. Utley;J. Côté;C. L. Peterson

  • The chromatin-associated protein H-NS alters DNA topology in vitro.

    A. E. Tupper;T. A. Owen-Hughes;D. W. Ussery;D. S. Santos

  • Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities

    Michael Bruno;Andrew Flaus;Chris Stockdale;Chantal Rencurel

  • Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

    Michael H Hauer;Michael H Hauer;Andrew Seeber;Andrew Seeber;Vijender Singh;Raphael Thierry

  • Protein H1: a role for chromatin structure in the regulation of bacterial gene expression and virulence?

    C. F. Higgins;J. C. D. Hinton;C. S. J. Hulton;T. Owen-Hughes

  • Experimental analysis of chromatin function in transcription control.

    Owen-Hughes T;Workman Jl

Frequent Co-Authors

David Norman
David Norman University of California, San Francisco
Jerry L. Workman
Jerry L. Workman Stowers Institute for Medical Research
Richard J. Ward
Richard J. Ward Universidade de São Paulo
Geoffrey J. Barton
Geoffrey J. Barton University of Dundee
Andrew J. Bannister
Andrew J. Bannister University of Cambridge
Dmitri I. Svergun
Dmitri I. Svergun European Bioinformatics Institute
Christopher F. Higgins
Christopher F. Higgins Hammersmith Hospital
Jay C. D. Hinton
Jay C. D. Hinton University of Liverpool
Mark Blaxter
Mark Blaxter Wellcome Sanger Institute

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