What is he best known for?
The fields of study he is best known for:
Tom Owen-Hughes mostly deals with Chromatin, Nucleosome, Cell biology, Chromatin remodeling and Histone.
Tom Owen-Hughes has begun a study into Chromatin, looking into Biochemistry and Genetics.
His study on Nucleosome is covered under DNA.
His Cell biology research is multidisciplinary, incorporating perspectives in TAF1, Molecular biology, Histone acetyltransferase, Chromatin structure remodeling complex and Transcription factor II D.
His studies examine the connections between Chromatin remodeling and genetics, as well as such issues in Regulation of gene expression, with regards to In vivo, Function, Therapeutic gene modulation, Gene product and DNA supercoil.
His research integrates issues of CHD1L and Proliferating cell nuclear antigen in his study of Histone.
His most cited work include:
- Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. (910 citations)
- The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity (652 citations)
- Identification of multiple distinct Snf2 subfamilies with conserved structural motifs (518 citations)
What are the main themes of his work throughout his whole career to date?
Tom Owen-Hughes focuses on Nucleosome, Chromatin, Cell biology, Histone and Chromatin remodeling.
His work on Histone octamer and Histone code as part of general Nucleosome study is frequently connected to Histone methylation, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His Chromatin research entails a greater understanding of Genetics.
His research on Cell biology also deals with topics like
- Chromatin structure remodeling complex together with Nucleosome binding,
- SWI/SNF, which have a strong connection to SWI/SNF complex.
His work deals with themes such as Molecular biology, Biophysics and Acetylation, which intersect with Histone.
His research in Chromatin remodeling tackles topics such as Enzyme which are related to areas like Chromatin remodelling.
He most often published in these fields:
- Nucleosome (59.29%)
- Chromatin (53.10%)
- Cell biology (49.56%)
What were the highlights of his more recent work (between 2017-2021)?
- Cell biology (49.56%)
- Chromatin (53.10%)
- Nucleosome (59.29%)
In recent papers he was focusing on the following fields of study:
Tom Owen-Hughes mostly deals with Cell biology, Chromatin, Nucleosome, Histone and DNA.
Cell biology is closely attributed to Chromatin remodeling in his research.
His study on Nucleosome sliding is often connected to Asymmetry as part of broader study in Chromatin.
His Nucleosome research includes elements of Chromatin remodelling and Proliferating cell nuclear antigen.
The study incorporates disciplines such as Biophysics, DNA replication and Gene isoform in addition to Histone.
His research in DNA intersects with topics in ATPase and Ubiquitin.
Between 2017 and 2021, his most popular works were:
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. (96 citations)
- Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome (59 citations)
- Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC. (20 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Chromatin remodeling, Cell biology, Translation, Polysome and Protein biosynthesis.
The Chromatin remodeling study combines topics in areas such as Structural biology, Regulation of gene expression and Nucleosome.
His Cell biology study combines topics from a wide range of disciplines, such as Histone, Bromodomain, DNA, Myeloid leukemia and Ubiquitin ligase.
His studies deal with areas such as Size-exclusion chromatography, Ribosomal RNA, Amino acid and Proteomics as well as Translation.
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