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Best Female Scientists
2025

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Best Female Scientists

D-Index
123
Citations
62544
World Ranking
471
National Ranking
273

Biology and Biochemistry

D-Index
127
Citations
67835
World Ranking
464
National Ranking
298

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2018 - Member of the National Academy of Sciences
  • 2013 - Fellow of the American Academy of Arts and Sciences
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Shelley L. Berger is affiliated with the University of Pennsylvania in the United States. Their research spans several disciplines within biochemistry, genetics, and molecular biology, with significant contributions to medicine as well.

The scientist has published extensively in the subfields of molecular biology, immunology, oncology, genetics, and physiology. Their main research topics include:

  • CAR-T cell therapy research
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Insect and Arachnid Ecology and Behavior
  • Histone Deacetylase Inhibitors Research

Shelley L. Berger has contributed to research published in various prominent venues. Frequent publication sources include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Molecular Cell
  • Cancer Research
  • Genes & Development

Some of their recent papers are:

  • Loss of epigenetic information as a cause of mammalian aging, 2023, Cell
  • SIRT1 is downregulated by autophagy in senescence and ageing, 2020, Nature Cell Biology
  • An NK-like CAR T cell transition in CAR T cell dysfunction, 2021, Cell
  • An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease, 2020, Nature Genetics
  • Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence, 2020, Genes & Development

The scientist has collaborated frequently with other researchers, including:

  • Hua Huang
  • Karl M. Glastad
  • Benjamin A. García
  • Greg Donahue
  • Charly R. Good

Throughout their career, Shelley L. Berger has been recognized with several honors. These awards include:

  • Member of the National Academy of Sciences, 2018
  • Fellow of the American Academy of Arts and Sciences, 2013
  • Fellow of the American Association for the Advancement of Science (AAAS), 2012

Best Publications

  • The complex language of chromatin regulation during transcription

    Shelley L. Berger

  • Acetylation of Histones and Transcription-Related Factors

    David E. Sterner;Shelley L. Berger

  • An operational definition of epigenetics

    Shelley L. Berger;Tony Kouzarides;Ramin Shiekhattar;Ali Shilatifard

  • Geroscience: Linking Aging to Chronic Disease

    Brian K. Kennedy;Shelley L. Berger;Anne Brunet;Judith Campisi;Judith Campisi

  • IDH mutation impairs histone demethylation and results in a block to cell differentiation

    Chao Lu;Patrick S. Ward;Patrick S. Ward;Gurpreet S. Kapoor;Dan Rohle;Dan Rohle

  • Histone modifications in transcriptional regulation.

    Shelley L Berger

  • TOX transcriptionally and epigenetically programs CD8 + T cell exhaustion

    Omar Khan;Josephine R. Giles;Sierra McDonald;Sasikanth Manne

  • Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

    P A Grant;L Duggan;J Côté;S M Roberts

  • Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

    Kristen E. Pauken;Morgan A. Sammons;Pamela M. Odorizzi;Sasikanth Manne

  • Cytoplasmic chromatin triggers inflammation in senescence and cancer

    Zhixun Dou;Kanad Ghosh;Maria Grazia Vizioli;Jiajun Zhu

  • New nomenclature for chromatin-modifying enzymes.

    C. David Allis;Shelley L. Berger;Jacques Cote;Sharon R Dent

  • p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.

    Lin Liu;Daniel M. Scolnick;Raymond C. Trievel;Hong Bing Zhang

  • Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

    Sean R. Collins;Kyle M. Miller;Nancy L. Maas;Assen Roguev

  • The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

    Craig A. Mizzen;Xiang Jiao Yang;Tetsuro Kokubo;James E. Brownell

  • p53 is regulated by the lysine demethylase LSD1

    Jing Huang;Roopsha Sengupta;Alexsandra B. Espejo;Min Gyu Lee

  • Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

    Nickolai A. Barlev;Lin Liu;Nabil H. Chehab;Kyle Mansfield

  • BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

    David E. Jensen;Monja Proctor;Sandra T. Marquis;Heather Perry Gardner

  • Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

    Karl W. Henry;Anastasia Wyce;Wan Sheng Lo;Laura J. Duggan

  • Epigenetic Mechanisms of Longevity and Aging.

    Payel Sen;Parisha P. Shah;Raffaella Nativio;Shelley L. Berger

  • Repression of p53 activity by Smyd2-mediated methylation.

    Jing Huang;Laura Perez-Burgos;Brandon J. Placek;Roopsha Sengupta

Frequent Co-Authors

Ronen Marmorstein
Ronen Marmorstein University of Pennsylvania
Danny Reinberg
Danny Reinberg University of Miami
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
Peter D. Adams
Peter D. Adams Sanford Burnham Prebys Medical Discovery Institute
Roberto Bonasio
Roberto Bonasio University of Pennsylvania
Laurence J. Zwiebel
Laurence J. Zwiebel Vanderbilt University
Jerry L. Workman
Jerry L. Workman Stowers Institute for Medical Research
C. David Allis
C. David Allis Rockefeller University
Nancy M. Bonini
Nancy M. Bonini University of Pennsylvania
E. John Wherry
E. John Wherry University of Pennsylvania

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