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Immunology

D-Index
137
Citations
113770
World Ranking
175
National Ranking
116

Medicine

D-Index
137
Citations
113793
World Ranking
1853
National Ranking
1056

Overview

E. John Wherry is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on several subfields including Immunology, Oncology, Infectious Diseases, Molecular Biology, and Neurology. This broad expertise reflects a comprehensive investigation into immune system functions and related medical disciplines.

The scientist's main research topics cover diverse aspects of immune cell activities with specific attention to Immune Cell Function and Interaction, T-cell and B-cell Immunology, and CAR-T cell therapy research. Further themes include Cancer Immunotherapy and Biomarkers, SARS-CoV-2 and COVID-19 Research, Immunotherapy and Immune Responses, as well as COVID-19 Clinical Research Studies.

Frequent coauthors include Divij Mathew, Josephine R. Giles, Allison R. Greenplate, Sasikanth Manne, and Amy E. Baxter, indicating a collaborative approach within the research community.

Major publication venues where their work frequently appears are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • The Journal of Immunology
  • Science Immunology
  • Immunity

Key recent papers authored by or involving E. John Wherry include:

  • Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications, 2020, Science
  • Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms, 2020, Immunity
  • mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern, 2021, Science
  • T cell responses in patients with COVID-19, 2020, Nature reviews. Immunology
  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, 2022, Nature

Best Publications

  • Molecular and cellular insights into T cell exhaustion

    E. John Wherry;Makoto Kurachi

  • T cell exhaustion

    E John Wherry

  • Restoring function in exhausted CD8 T cells during chronic viral infection.

    Daniel L. Barber;E. John Wherry;David Masopust;Baogong Zhu

  • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

    Cheryl L Day;Daniel E Kaufmann;Photini Kiepiela;Julia A Brown

  • Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

    Gang Chen;Alexander C. Huang;Wei Zhang;Wei Zhang;Gao Zhang

  • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

    Christina Twyman-Saint Victor;Andrew J. Rech;Amit Maity;Ramesh Rengan;Ramesh Rengan

  • Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

    E. John Wherry;Sang Jun Ha;Susan M. Kaech;W. Nicholas Haining

  • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

    Shawn D Blackburn;Haina Shin;W Nicholas Haining;W Nicholas Haining;Tao Zou

  • Effector and memory T-cell differentiation: implications for vaccine development

    Susan M. Kaech;E. John Wherry;Rafi Ahmed

  • Lineage relationship and protective immunity of memory CD8 T cell subsets.

    E. John Wherry;Volker Teichgräber;Todd C. Becker;David Masopust

  • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

    Susan M Kaech;Joyce T Tan;E John Wherry;Bogumila T Konieczny

  • Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

    E. John Wherry;Joseph N. Blattman;Kaja Murali-Krishna;Robbert van der Most

  • CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

    Laura M. McLane;Mohamed S. Abdel-Hakeem;E. John Wherry

  • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

    Arlene H Sharpe;E John Wherry;Rafi Ahmed;Gordon J Freeman

  • Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

    Joseph A. Fraietta;Simon F. Lacey;Elena J. Orlando;Iulian Pruteanu-Malinici

  • T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

    Alexander C. Huang;Michael A. Postow;Michael A. Postow;Robert J. Orlowski;Rosemarie Mick

  • Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

    Laurel A Monticelli;Gregory F Sonnenberg;Michael C Abt;Theresa Alenghat

  • Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

    Divij Mathew;Josephine R. Giles;Amy E. Baxter;Derek A. Oldridge

  • TOX transcriptionally and epigenetically programs CD8 + T cell exhaustion

    Omar Khan;Josephine R. Giles;Sierra McDonald;Sasikanth Manne

  • Effector and memory CD8 + T cell fate coupled by T-bet and eomesodermin

    Andrew M Intlekofer;Naofumi Takemoto;E John Wherry;E John Wherry;Sarah A Longworth

  • Defining ‘T cell exhaustion’

    Christian U Blank;W Nicholas Haining;Werner Held;Patrick G Hogan;Patrick G Hogan

Frequent Co-Authors

Rafi Ahmed
Rafi Ahmed Emory University
W. Nicholas Haining
W. Nicholas Haining Arsenal Biosciences (United States)
Susan M. Kaech
Susan M. Kaech Salk Institute for Biological Studies
Scott E. Hensley
Scott E. Hensley University of Pennsylvania
Michael R. Betts
Michael R. Betts University of Pennsylvania
Gordon J. Freeman
Gordon J. Freeman Harvard University
Sarah E. Henrickson
Sarah E. Henrickson Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Robert H. Vonderheide
Robert H. Vonderheide University of Pennsylvania
David Masopust
David Masopust University of Minnesota
Arlene H. Sharpe
Arlene H. Sharpe Harvard University

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