2026 Mark J. Smyth: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	188	456	422	1	1	788	135126
Immunology	191	20	19	1	1	781	142460
Medicine	191	252	229	4	3	784	142460

Research.com Recognitions

2026 - Research.com Immunology in Australia Leader Award
2026 - Research.com Medicine in Australia Leader Award
2025 - Research.com Best Scientists Award
2025 - Research.com Immunology in Austria Leader Award
2025 - Research.com Medicine in Austria Leader Award
2023 - Research.com Immunology in Australia Leader Award
2023 - Research.com Medicine in Australia Leader Award
2022 - Research.com Immunology in Australia Leader Award
2022 - Research.com Medicine in Australia Leader Award
2017 - Fellow of the Australian Academy of Science
1995 - Gottschalk Medal, Australian Academy of Science

Overview

Mark J. Smyth is an independent scientist and consultant based in Australia whose research primarily spans the fields of immunology and microbiology, with significant contributions to medicine. Smyth's work focuses on immunology, oncology, and molecular biology, supported by research themes in immune cell function and interaction, cancer immunotherapy and biomarkers, and CAR-T cell therapy research.

The scientist's publication record includes research in frequent coauthorship with Tobias Bald, Kyohei Nakamura, Christian Engwerda, Xian-Yang Li, and Michele W.L. Teng, each collaborating on multiple papers.

Smyth has published extensively in notable journals such as Nature Immunology, Immunity, Cancer Immunology Research, Journal of Clinical Investigation, and the Journal for ImmunoTherapy of Cancer. These venues reflect the interdisciplinary nature of Smyth's research within immunology and oncology.

Nature Immunology (5 publications)
Immunity (4 publications)
Cancer Immunology Research (3 publications)
Journal of Clinical Investigation (3 publications)
Journal for ImmunoTherapy of Cancer (2 publications)

Among recent scholarly contributions, Smyth is associated with papers such as:

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death, 2020, Journal for ImmunoTherapy of Cancer
The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies, 2020, Nature Immunology
Targeting CD39 in cancer, 2020, Nature Reviews Immunology
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation, 2020, Nature Immunology
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection, 2021, Cell

The scientist's research topics include immune cells in cancer, T-cell and B-cell immunology, immunotherapy and immune responses, and peptidase inhibition and analysis. Smyth's work intersects with areas of physiology and even aspects of electrical and electronic engineering, indicating a multidisciplinary approach.

Immune Cell Function and Interaction
Cancer Immunotherapy and Biomarkers
CAR-T cell therapy research
Immunotherapy and Immune Responses
Peptidase Inhibition and Analysis
Immune cells in cancer
T-cell and B-cell Immunology

Smyth's career includes recognition in the form of awards, notably the Gottschalk Medal from the Australian Academy of Science in 1995 and being elected a Fellow of the Australian Academy of Science in 2017.

Best Publications

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Robert D. Schreiber;Lloyd J. Old;Mark J. Smyth;Mark J. Smyth

7431
Citations
Natural Innate and Adaptive Immunity to Cancer

Matthew D. Vesely;Michael H. Kershaw;Michael H. Kershaw;Michael H. Kershaw;Robert D. Schreiber;Mark J. Smyth;Mark J. Smyth

2589
Citations
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

François Ghiringhelli;Lionel Apetoh;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Laetitia Aymeric;Laetitia Aymeric;Laetitia Aymeric

2102
Citations
Immune surveillance of tumors.

Jeremy B. Swann;Mark J. Smyth

1937
Citations
New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape

Deepak Mittal;Matthew M Gubin;Robert D Schreiber;Mark J Smyth;Mark J Smyth

1775
Citations
Adaptive immunity maintains occult cancer in an equilibrium state

Catherine M. Koebel;William Vermi;William Vermi;Jeremy B. Swann;Jeremy B. Swann;Nadeen Zerafa

1770
Citations
Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O’Donnell;Jake S. O’Donnell;Michele W. L. Teng;Michele W. L. Teng;Mark J. Smyth;Mark J. Smyth

1716
Citations
Functional significance of the perforin/granzyme cell death pathway

Joseph A. Trapani;Mark J. Smyth

1656
Citations
NKT cells: what's in a name?

Dale I Godfrey;H Robson MacDonald;Mitchell Kronenberg;Mark J Smyth

1563
Citations
Classifying Cancers Based on T-cell Infiltration and PD-L1

Michele W.L. Teng;Michele W.L. Teng;Shin Foong Ngiow;Antoni Ribas;Mark J. Smyth;Mark J. Smyth

1547
Citations
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

Hirokazu Matsushita;Hirokazu Matsushita;Matthew D. Vesely;Daniel C. Koboldt;Charles G. Rickert

1447
Citations
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

S. Loi;S. Loi;S. Michiels;S. Michiels;R. Salgado;N. Sirtaine

1433
Citations
Type I interferons in anticancer immunity

Laurence Zitvogel;Lorenzo Galluzzi;Oliver Kepp;Mark J. Smyth

1360
Citations
Translational biology of osteosarcoma

Maya Kansara;Michele W. Teng;Mark J. Smyth;David M. Thomas

1311
Citations
NKT cells: facts, functions and fallacies

Dale I. Godfrey;Kirsten J.L. Hammond;Lynn D. Poulton;Mark J. Smyth

1144
Citations
Targeting natural killer cells in cancer immunotherapy

Camille Guillerey;Camille Guillerey;Nicholas D Huntington;Nicholas D Huntington;Mark J Smyth;Mark J Smyth

1125
Citations
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Antonella Sistigu;Takahiro Yamazaki;Erika Vacchelli;Kariman Chaba

1122
Citations
Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity

Mark J. Smyth;Gavin P. Dunn;Robert D. Schreiber

1118
Citations
Differential tumor surveillance by natural killer (NK) and NKT cells

Mark J. Smyth;Kevin Y. T. Thia;Shayna E.A. Street;Erika Cretney

1108
Citations
A fresh look at tumor immunosurveillance and immunotherapy

Mark J. Smyth;Dale I. Godfrey;Joseph A. Trapani

1064
Citations

Frequent Co-Authors

Michele W. L. Teng QIMR Berghofer Medical Research Institute

Joseph A. Trapani Peter MacCallum Cancer Centre

Phillip K. Darcy Peter MacCallum Cancer Centre

Michael H. Kershaw Peter MacCallum Cancer Centre

Dale I. Godfrey University of Melbourne

Geoffrey R. Hill Fred Hutchinson Cancer Research Center

Kazuyoshi Takeda Juntendo University

Hideo Yagita Juntendo University

Shin Foong Ngiow University of Pennsylvania

Yoshihiro Hayakawa Aichi Institute of Technology

External Links

Personal website of Mark J. Smyth

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