World's Best Scientists 2026 revealed!

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Immunology

D-Index
87
Citations
25264
World Ranking
1217
National Ranking
42

Medicine

D-Index
87
Citations
25292
World Ranking
13736
National Ranking
453

Overview

Phillip K. Darcy is affiliated with the Peter MacCallum Cancer Centre in Australia. Their primary fields of study are Medicine and Immunology and Microbiology, with significant contributions across related subfields such as Oncology, Immunology, Molecular Biology, Genetics, and Pulmonary and Respiratory Medicine.

The main topics covered in their research include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immune cells in cancer
  • CRISPR and Genetic Engineering

Their publication record includes notable papers such as:

  • "Cellular networks controlling T cell persistence in adoptive cell therapy" (2021) published in Nature Reviews. Immunology
  • "Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity" (2020) published in Nature Immunology
  • "CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy" (2021) published in Nature Communications
  • "Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer" (2023) published in Cancer Cell
  • "FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy" (2024) published in Nature

The venues where Phillip K. Darcy has frequently published include:

  • Regular and Young Investigator Award Abstracts
  • Nature Communications
  • Cytotherapy
  • Cancer Cell
  • Journal of Clinical Oncology

Frequent collaborators in their research include:

  • Paul J. Neeson
  • Paul A. Beavis
  • Kevin Sek
  • Joseph A. Trapani
  • Imran G. House

Phillip K. Darcy's work spans multidisciplinary areas involving cellular therapies, immunotherapy mechanisms, and genetic engineering approaches such as CRISPR. Their research on CAR-T cell therapies is especially prominent, reflecting sustained interest in enhancing immune system function to target cancer effectively.

Best Publications

  • Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

    Peter Savas;Balaji Virassamy;Chengzhong Ye;Agus Salim;Agus Salim

  • Clinical relevance of host immunity in breast cancer: from TILs to the clinic

    Peter Savas;Roberto Salgado;Carsten Denkert;Christos Sotiriou

  • CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

    Marian L Burr;Marian L Burr;Marian L Burr;Christina E Sparbier;Yih-Chih Chan;James C Williamson

  • Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

    Liza B John;Christel Devaud;Connie P M Duong;Carmen S M Yong

  • Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade.

    Imran G House;Imran G House;Peter Savas;Peter Savas;Junyun Lai;Junyun Lai;Amanda X. Y. Chen;Amanda X. Y. Chen

  • Gene-engineered T cells for cancer therapy

    Michael H Kershaw;Jennifer A Westwood;Phillip K Darcy;Phillip K Darcy

  • Activating and inhibitory receptors of natural killer cells.

    Hollie J Pegram;Daniel M Andrews;Mark J Smyth;Phillip K Darcy

  • RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: therapeutic cooperation between MEK and PD-1/PD-L1 immune checkpoint inhibitors

    Sherene Loi;Sherene Loi;Sathana Dushyanthen;Paul A. Beavis;Roberto Salgado

  • Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

    Leisha A. Emens;Paolo A. Ascierto;Phillip K. Darcy;Sandra Demaria

  • CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

    Sherene Loi;Sandra Pommey;Benjamin Haibe-Kains;Paul A Beavis

  • Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

    David S. Ritchie;Paul J. Neeson;Paul J. Neeson;Amit Khot;Stefan Peinert

  • Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection.

    Janice M Kelly;Phillip K Darcy;Jessica L Markby;Dale I Godfrey

  • Trafficking of T Cells into Tumors

    Clare Y. Slaney;Clare Y. Slaney;Michael H. Kershaw;Phillip K. Darcy

  • CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

    John Stagg;Upulie Divisekera;Helene Duret;Tim Sparwasser

  • CD73: a potent suppressor of antitumor immune responses

    Paul. A. Beavis;John Stagg;Phillip K. Darcy;Phillip K. Darcy;Mark J. Smyth;Mark J. Smyth

  • Tumor immune evasion arises through loss of TNF sensitivity

    Conor J. Kearney;Conor J. Kearney;Stephin J. Vervoort;Stephin J. Vervoort;Simon J. Hogg;Simon J. Hogg;Kelly M. Ramsbottom

  • Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

    Paul A. Beavis;Upulie Divisekera;Upulie Divisekera;Christophe Paget;Christophe Paget;Melvyn T. Chow;Melvyn T. Chow

  • Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity.

    A J Davenport;R S Cross;R S Cross;K A Watson;Y Liao

  • Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer.

    Emma Nolan;Emma Nolan;Peter Savas;Peter Savas;Antonia N. Policheni;Antonia N. Policheni;Phillip K. Darcy;Phillip K. Darcy

  • Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses

    Paul A. Beavis;Paul A. Beavis;Nicole Milenkovski;Nicole Milenkovski;Melissa A. Henderson;Melissa A. Henderson;Liza B. John;Liza B. John

  • A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

    Mandy J. Ludford-Menting;Jane Oliaro;Faruk Sacirbegovic;Eric T.-Y. Cheah

  • Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

    Paul A. Beavis;Paul A. Beavis;Melissa A. Henderson;Melissa A. Henderson;Lauren Giuffrida;Lauren Giuffrida;Jane K. Mills;Jane K. Mills

Frequent Co-Authors

Michael H. Kershaw
Michael H. Kershaw Peter MacCallum Cancer Centre
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Paul A. Beavis
Paul A. Beavis Peter MacCallum Cancer Centre
Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Sherene Loi
Sherene Loi Peter MacCallum Cancer Centre
Robert G. Ramsay
Robert G. Ramsay Peter MacCallum Cancer Centre
Michele W. L. Teng
Michele W. L. Teng QIMR Berghofer Medical Research Institute
Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre
David Ritchie
David Ritchie Peter MacCallum Cancer Centre
Ilia Voskoboinik
Ilia Voskoboinik Peter MacCallum Cancer Centre

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