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Immunology

D-Index
107
Citations
44471
World Ranking
546
National Ranking
327

Medicine

D-Index
107
Citations
44587
World Ranking
6219
National Ranking
3315

Overview

Gianpietro Dotti is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on the field of medicine, with a substantial number of publications in oncology, immunology, genetics, molecular biology, and biomedical engineering.

The main topics of Gianpietro Dotti's research work include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Virus-based gene therapy research
  • Immunotherapy and Immune Responses
  • Viral Infectious Diseases and Gene Expression in Insects
  • Nanowire Synthesis and Applications
  • Neuroblastoma Research and Treatments

Gianpietro Dotti has contributed to several recent publications that highlight their focus on immunotherapy and cell therapy approaches. Notable papers include:

  • Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours, 2022, Nature Reviews Clinical Oncology
  • Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma, 2020, Journal of Clinical Oncology
  • Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets, 2021, Nature Biomedical Engineering
  • Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis, 2020, Nature Medicine
  • Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy, 2020, Proceedings of the National Academy of Sciences

Frequent co-authors who have collaborated with Gianpietro Dotti include:

  • Barbara Savoldo
  • Elisa Landoni
  • Natalie S. Grover
  • Jonathan S. Serody
  • Catherine Cheng

In terms of publication outlets, their work is often featured in:

  • UNC Libraries
  • Blood
  • Journal for ImmunoTherapy of Cancer
  • Nature Communications
  • Clinical Cancer Research

Best Publications

  • Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.

    van Dongen Jj;Macintyre Ea;Gabert Ja;Delabesse E

  • Inducible apoptosis as a safety switch for adoptive cell therapy

    Antonio Di Stasi;Siok Keen Tey;Gianpietro Dotti;Yuriko Fujita

  • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

    Martin A. Pule;Barbara Savoldo;G. Doug Myers;G. Doug Myers;Claudia Rossig

  • Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

    Chrystal U. Louis;Chrystal U. Louis;Barbara Savoldo;Barbara Savoldo;Gianpietro Dotti;Gianpietro Dotti;Martin Pule

  • CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

    Barbara Savoldo;Carlos Almeida Ramos;Carlos Almeida Ramos;Enli Liu;Martha P. Mims

  • Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

    Nabil Ahmed;Vita S. Brawley;Meenakshi Hegde;Catherine Robertson

  • In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

    Qian Chen;Qian Chen;Chao Wang;Xudong Zhang;Guojun Chen

  • An inducible caspase 9 safety switch for T-cell therapy

    Karin C. Straathof;Martin A. Pulè;Patricia Yotnda;Gianpietro Dotti

  • HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial

    Nabil Ahmed;Nabil Ahmed;Vita Brawley;Vita Brawley;Meenakshi Hegde;Meenakshi Hegde;Kevin Bielamowicz

  • Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

    Yang Xu;Ming Zhang;Carlos A. Ramos;April Durett

  • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes

    Ignazio Caruana;Barbara Savoldo;Valentina Hoyos;Gerrit Weber

  • Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

    Enli Liu;Yijiu Tong;Gianpietro Dotti;Hila Shaim

  • Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

    Meenakshi Hegde;Malini Mukherjee;Malini Mukherjee;Zakaria Grada;Antonella Pignata

  • Design and development of therapies using chimeric antigen receptor-expressing T cells

    Gianpietro Dotti;Stephen Gottschalk;Barbara Savoldo;Malcolm K. Brenner

  • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

    Valentina Hoyos;Barbara Savoldo;Barbara Savoldo;Concetta Quintarelli;Aruna Mahendravada

  • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

    Martin A. Pulè;Karin C. Straathof;Karin C. Straathof;Gianpietro Dotti;Gianpietro Dotti;Helen E. Heslop

  • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.

    Antonio Di Stasi;Biagio De Angelis;Cliona M. Rooney;Lan Zhang

  • Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

    Conrad Russell Y. Cruz;Kenneth P. Micklethwaite;Barbara Savoldo;Carlos A. Ramos

  • In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy.

    Chao Wang;Jinqiang Wang;Xudong Zhang;Shuangjiang Yu

  • TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

    Zakaria Grada;Zakaria Grada;Meenakshi Hegde;Meenakshi Hegde;Tiara Byrd;Tiara Byrd;Donald R Shaffer;Donald R Shaffer

Frequent Co-Authors

Barbara Savoldo
Barbara Savoldo University of North Carolina at Chapel Hill
Malcolm K. Brenner
Malcolm K. Brenner Baylor College of Medicine
Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Catherine M. Bollard
Catherine M. Bollard George Washington University
Hao Liu
Hao Liu Indiana University
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
Elizabeth J. Shpall
Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center
Ann M. Leen
Ann M. Leen Baylor College of Medicine

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