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Biology and Biochemistry

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Overview

Laurence J.N. Cooper is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans multiple areas within medicine, with a focus on oncology and related biochemistry, genetics, and molecular biology disciplines.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields of specialization cover:

  • Oncology
  • Immunology
  • Genetics
  • Molecular Biology
  • Biotechnology

The core topics of their research work are:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Cancer Research and Treatments
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • SARS-CoV-2 and COVID-19 Research
  • Glioma Diagnosis and Treatment

Laurence J.N. Cooper has contributed to several recent papers in notable journals, illustrating ongoing work in the field of cancer immunotherapy and cellular therapies:

  • Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial, 2021, Neuro-Oncology
  • Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma, 2020, Neuro-Oncology
  • Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses, 2022, Journal of Clinical Investigation
  • Long-term outcomes of Sleeping Beauty-generated CD19-specific CAR T-cell therapy for relapsed-refractory B-cell lymphomas, 2020, Blood
  • Adoptive immunotherapy with double-bright (CD56bright/CD16bright) expanded natural killer cells in patients with relapsed or refractory acute myeloid leukaemia: a proof-of-concept study, 2021, British Journal of Haematology

Their frequent co-authors include:

  • Navin Varadarajan
  • Jill Buck
  • Harjeet Singh
  • Melisa Martinez-Paniagua
  • Nira Hadar

Laurence J.N. Cooper publishes regularly in several scientific venues, with the highest number of publications appearing in:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Nature Cancer
  • Blood

Best Publications

  • Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao;Lifeng Yang;Joelle Baddour;Abhinav Achreja

  • Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

    Cecele J. Denman;Vladimir V. Senyukov;Srinivas S. Somanchi;Prasad V. Phatarpekar

  • CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor Enhances In vivo Persistence and Antitumor Efficacy of Adoptively Transferred T Cells

    Claudia M. Kowolik;Max S. Topp;Sergio Gonzalez;Timothy Pfeiffer

  • Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans

    Michael C. Jensen;Leslie Popplewell;Laurence J. Cooper;David DiGiusto

  • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

    Hiroki Torikai;Andreas Reik;Pei Qi Liu;Yuanyue Zhou

  • Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

    Partow Kebriaei;Harjeet Singh;M. Helen Huls;Matthew J. Figliola

  • Cord-blood engraftment with ex vivo mesenchymal-cell coculture.

    Marcos J.G. de Lima;Ian McNiece;Simon N. Robinson;Mark Munsell

  • Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.

    Konrad Gabrusiewicz;Benjamin Rodriguez;Jun Wei;Yuuri Hashimoto

  • Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.

    Lenka V. Hurton;Lenka V. Hurton;Harjeet Singh;Amer M. Najjar;Kirsten C. Switzer

  • Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.

    Bipulendu Jena;Gianpietro Dotti;Laurence J. N. Cooper

  • Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.

    Julia Tchou;Yangbing Zhao;Bruce L Levine;Paul J Zhang

  • Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

    David A. Knorr;Zhenya Ni;David L Lampi Hermanson;Melinda K. Hexum

  • Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

    Hillary G. Caruso;Hillary G. Caruso;Lenka V. Hurton;Lenka V. Hurton;Amer Najjar;David Rushworth;David Rushworth

  • Specific Recognition and Killing of Glioblastoma Multiforme by Interleukin 13-Zetakine Redirected Cytolytic T Cells

    Kanwarpal S. Kahlon;Christine Brown;Laurence J. N. Cooper;Andrew Raubitschek

  • Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing

    Krishna V. Komanduri;Lisa S. St. John;Marcos J.G. de Lima;John McMannis

  • Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

    Matthew J. Frigault;Jihyun Lee;Maria Ciocca Basil;Carmine Carpenito

  • Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

    Hiroki Torikai;Andreas Reik;Frank Soldner;Edus H. Warren

  • T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B–lineage leukemia effect

    Laurence J N Cooper;Laurence J N Cooper;Max S Topp;Max S Topp;Lisa Marie A Serrano;Lisa Marie A Serrano;Sergio Gonzalez;Sergio Gonzalez

  • Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

    Xiuli Wang;Leslie L. Popplewell;Jamie R. Wagner;Araceli Naranjo

  • Redirecting Specificity of T-Cell Populations For CD19 Using the Sleeping Beauty System

    Harjeet Singh;Pallavi R. Manuri;Simon Olivares;Navid Dara

Frequent Co-Authors

Richard E. Champlin
Richard E. Champlin The University of Texas MD Anderson Cancer Center
Dean A. Lee
Dean A. Lee Nationwide Children's Hospital
Elizabeth J. Shpall
Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center
Partow Kebriaei
Partow Kebriaei The University of Texas MD Anderson Cancer Center
Michael C. Jensen
Michael C. Jensen Seattle Children's Hospital
Catherine M. Bollard
Catherine M. Bollard George Washington University
Perry B. Hackett
Perry B. Hackett University of Minnesota
Stephen J. Forman
Stephen J. Forman City Of Hope National Medical Center
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Jeffrey J. Molldrem
Jeffrey J. Molldrem The University of Texas MD Anderson Cancer Center

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