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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
27687
World Ranking
8943
National Ranking
3970

Overview

Michael C. Milone is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on areas within medicine, with a substantial body of work in oncology, immunology, genetics, molecular biology, and biomedical engineering.

Their main research topics include:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Nanowire synthesis and applications
  • Immune cell function and interaction
  • Viral infectious diseases and gene expression in insects
  • T-cell and B-cell immunology
  • CRISPR and genetic engineering

Michael C. Milone has published extensively in several scientific venues. The most frequent venues of publication include:

  • Blood
  • Molecular Therapy
  • Regular and Young Investigator Award Abstracts
  • The Journal of Immunology
  • Nature Cancer

Their recent papers highlight significant contributions to immunotherapy and cellular engineering. Selected publications include:

  • "Rapid manufacturing of non-activated potent CAR T cells," 2022, Nature Biomedical Engineering
  • "Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers," 2020, JAMA Internal Medicine
  • "4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling," 2020, Science Signaling
  • "Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells," 2023, Nature Biotechnology
  • "Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris," 2020, Journal of Clinical Investigation

Frequent collaborators in their research include Selene Nuñez-Cruz, Carl H. June, Roddy S. O'Connor, Alfred L. Garfall, and Vijay Bhoj, evidencing established research partnerships in the field.

Best Publications

  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

    Stephan A. Grupp;Michael Kalos;David Barrett;Richard Aplenc

  • CAR T cell immunotherapy for human cancer

    Carl H. June;Roddy S. O’Connor;Omkar U. Kawalekar;Saba Ghassemi

  • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

    David L. Porter;Wei-Ting Hwang;Noelle V. Frey;Simon F. Lacey

  • Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

    Michael C. Milone;Jonathan D. Fish;Jonathan D. Fish;Carmine Carpenito;Richard G. Carroll

  • Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

    Omkar U. Kawalekar;Roddy S. O’Connor;Joseph A. Fraietta;Lili Guo

  • Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

    Carmine Carpenito;Michael C. Milone;Raffit Hassan;Jacqueline C. Simonet

  • Use of chimeric antigen receptor-modified t cells to treat cancer

    Carl H. June;Bruce L. Levine;David L. Porter;Michael D. Kalos

  • B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

    Adam D. Cohen;Alfred L. Garfall;Edward A. Stadtmauer;J. Joseph Melenhorst

  • Clinical use of lentiviral vectors.

    Michael C. Milone;Una O’Doherty

  • Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.

    Christoph T. Ellebrecht;Vijay G. Bhoj;Arben Nace;Eun Jung Choi

  • An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

    Steven Feins;Weimin Kong;Erik F. Williams;Michael C. Milone

  • Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

    Yan Xiang;Zachary E. Stine;Jinsong Xia;Yunqi Lu

  • Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors

    Edmund K. Moon;Liang-Chuan Wang;Douglas V. Dolfi;Caleph B. Wilson

  • Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

    Matthew J. Frigault;Jihyun Lee;Maria Ciocca Basil;Carmine Carpenito

  • USE OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELLS TO TREAT MALIGNANCIES

    June Carl H;Porter David L;Kalos Michael D;Milone Michael C

  • Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

    Megan M Suhoski;Tatiana N Golovina;Nicole A Aqui;Victoria C Tai

  • Substrate Rigidity Regulates Human T Cell Activation and Proliferation

    Roddy S. O’Connor;Xueli Hao;Keyue Shen;Keenan Bashour

  • High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model.

    Sarah A. Richman;Selene Nunez-Cruz;Babak Moghimi;Lucy Z. Li

  • Beta-lactamases with improved properties for therapy

    Loew Andreas;Milone Michael C;Powell Daniel J;Zhao Yangbing

  • Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

    Saba Ghassemi;Selene Nunez-Cruz;Roddy S. O'Connor;Joseph A. Fraietta

Frequent Co-Authors

Carl H. June
Carl H. June University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
David L. Porter
David L. Porter University of Pennsylvania
Simon F. Lacey
Simon F. Lacey University of Pennsylvania
Edward A. Stadtmauer
Edward A. Stadtmauer University of Pennsylvania
Michael Kalos
Michael Kalos Next Pillar Consulting
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania
Leslie M. Shaw
Leslie M. Shaw University of Pennsylvania
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
James L. Riley
James L. Riley University of Pennsylvania

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