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Immunology

D-Index
55
Citations
23249
World Ranking
3770
National Ranking
1727

Overview

David M. Barrett is affiliated with the Children's Hospital of Philadelphia in the United States. Their research focuses primarily on medicine, with a significant emphasis on oncology, immunology, molecular biology, hematology, and public health, environmental and occupational health.

The scientist's work covers several key topics including CAR-T cell therapy research, immune cell function and interaction, acute lymphoblastic leukemia research, viral infectious diseases and gene expression in insects, virus-based gene therapy research, nanowire synthesis and applications, and hematopoietic stem cell transplantation.

David M. Barrett has collaborated frequently with several researchers. Notable co-authors include:

  • Stephan A. Grupp
  • Carl H. June
  • Regina M. Myers
  • David T. Teachey
  • Hamid Bassiri

Their research has been published mainly in the following venues:

  • Blood
  • Nature Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Clinical Cancer Research

Selected recent papers authored or co-authored by David M. Barrett include:

  • Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2, 2020, Journal of Clinical Investigation
  • Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results, 2024, Nature Medicine
  • Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial, 2021, Journal of Clinical Oncology
  • Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells, 2021, Nature Medicine
  • Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy, 2021, Cancer Discovery

Best Publications

  • Chimeric antigen receptor T cells for sustained remissions in leukemia.

    Shannon L. Maude;Noelle Frey;Pamela A. Shaw;Richard Aplenc

  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

    Stephan A. Grupp;Michael Kalos;David Barrett;Richard Aplenc

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

    David T. Teachey;David T. Teachey;Simon F. Lacey;Pamela A. Shaw;J. Joseph Melenhorst

  • Managing cytokine release syndrome associated with novel T cell-engaging therapies.

    Shannon L. Maude;David Barrett;David T. Teachey;Stephan A. Grupp

  • Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

    Waleed Haso;Daniel W. Lee;Nirali N. Shah;Maryalice Stetler-Stevenson

  • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy.

    David T. Teachey;David T. Teachey;Susan R. Rheingold;Susan R. Rheingold;Shannon L. Maude;Shannon L. Maude;Gerhard Zugmaier

  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    Marco Ruella;Jun Xu;David M. Barrett;Joseph A. Fraietta

  • Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

    Marco Ruella;David M. Barrett;Saad S. Kenderian;Olga Shestova

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

    Joseph A. Fraietta;Kyle A. Beckwith;Prachi R. Patel;Marco Ruella

  • Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia

    Julie C Fitzgerald;Scott L Weiss;Shannon L Maude;David M Barrett

  • Chimeric Antigen Receptor Therapy for Cancer

    David M. Barrett;Nathan Singh;David L. Porter;Stephan A. Grupp

  • Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2.

    Caroline Diorio;Sarah E. Henrickson;Laura A. Vella;Kevin O. McNerney

  • Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

    Shannon L. Maude;Shannon L. Maude;Sarah K. Tasian;Sarah K. Tasian;Tiffaney Vincent;Junior W. Hall

  • Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome

    Chelsea Kotch;David Barrett;David T. Teachey

  • Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies.

    Nathan Singh;Jessica Perazzelli;Stephan A. Grupp;David M. Barrett

  • High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model.

    Sarah A. Richman;Selene Nunez-Cruz;Babak Moghimi;Lucy Z. Li

  • Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

    David M. Barrett;Yangbing Zhao;Xiaojun Liu;Shuguang Jiang

  • Particulate silicone for use in periurethral injections : local tissue effects and search for migration

    David R. Henly;David M. Barrett;Timothy L. Weiland;Michael K. O'Connor

  • Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia

    Karen L. Bride;Tiffaney L. Vincent;Soo Yeon Im;Richard Aplenc

  • Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.

    David M. Barrett;Stephan A. Grupp;Carl H. June

  • Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.

    Rajat K. Das;Lauren Vernau;Stephan A. Grupp;David M. Barrett

  • Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial.

    Stephan Kadauke;Regina M Myers;Regina M Myers;Yimei Li;Richard Aplenc;Richard Aplenc

  • Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy.

    Gregory M. Chen;Changya Chen;Rajat K. Das;Peng Gao

  • Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

    Nathan Singh;Noelle V. Frey;Boris Engels;David M. Barrett

  • Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia.

    Regina M Myers;Yimei Li;Allison Barz Leahy;David M Barrett

Frequent Co-Authors

Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
David T. Teachey
David T. Teachey Children's Hospital of Philadelphia
Carl H. June
Carl H. June University of Pennsylvania
Simon F. Lacey
Simon F. Lacey University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
David L. Porter
David L. Porter University of Pennsylvania
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania
Michael Kalos
Michael Kalos Next Pillar Consulting
Kai Tan
Kai Tan Children's Hospital of Philadelphia
Michael C. Milone
Michael C. Milone University of Pennsylvania

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Related Online Degrees & Career Pathways

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