World's Best Scientists 2026 revealed!

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Immunology

D-Index
103
Citations
65603
World Ranking
629
National Ranking
367

Medicine

D-Index
103
Citations
65718
World Ranking
7171
National Ranking
3766

Research.com Recognitions

  • 2019 - Member of the National Academy of Medicine (NAM)

Overview

Stephan A. Grupp is affiliated with Children's Hospital of Philadelphia in the United States and focuses on medical research with an emphasis on oncology, genetics, hematology, molecular biology, and public health. Their work spans a variety of topics primarily related to CAR-T cell therapy research, acute lymphoblastic leukemia, hematopoietic stem cell transplantation, viral infectious diseases, gene therapy, hemoglobinopathies, and immune cell function.

Their recent publications include the following:

  • CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia (2020), published in New England Journal of Medicine
  • 'Off-the-shelf' allogeneic CAR T cells: development and challenges (2020), published in Nature Reviews Drug Discovery
  • Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 (2020), published in Journal of Clinical Investigation
  • Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma (2020), published in Blood Advances
  • Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction (2020), published in Cancer Discovery

Stephan A. Grupp's frequent co-authors include:

  • Regina M. Myers (48 publications)
  • Shannon L. Maude (38 publications)
  • Amanda M. DiNofia (35 publications)
  • Michael A. Pulsipher (31 publications)
  • Allison Barz Leahy (29 publications)

They regularly publish in several scientific journals. The most frequent publication venues are:

  • Blood (44 publications)
  • Transplantation and Cellular Therapy (40 publications)
  • Blood Advances (20 publications)
  • Journal of Clinical Oncology (11 publications)
  • Clinical Lymphoma Myeloma & Leukemia (6 publications)

The main fields of study in their research encompass Medicine with significant contributions in oncology (131 publications), genetics (60 publications), hematology (58 publications), molecular biology (57 publications), and public health, environmental and occupational health (43 publications).

The primary research topics associated with their work include:

  • CAR-T cell therapy research (238 publications)
  • Acute Lymphoblastic Leukemia research (84 publications)
  • Hematopoietic Stem Cell Transplantation (64 publications)
  • Viral Infectious Diseases and Gene Expression in Insects (50 publications)
  • Virus-based gene therapy research (46 publications)
  • Hemoglobinopathies and Related Disorders (44 publications)
  • Immune Cell Function and Interaction (30 publications)

Stephan A. Grupp was recognized as a Member of the National Academy of Medicine (NAM) in 2019, reflecting participation in a prominent professional body within the medical field.

Best Publications

  • Chimeric antigen receptor T cells for sustained remissions in leukemia.

    Shannon L. Maude;Noelle Frey;Pamela A. Shaw;Richard Aplenc

  • Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

    S. L. Maude;Theodore W Laetsch;J. Buechner;S. Rives

  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

    Stephan A. Grupp;Michael Kalos;David Barrett;Richard Aplenc

  • ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells

    Daniel W. Lee;Bianca D. Santomasso;Frederick L. Locke;Armin Ghobadi

  • T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

    Michael Kalos;Bruce L. Levine;David L. Porter;Sharyn Katz

  • Current concepts in the diagnosis and management of cytokine release syndrome

    Daniel W. Lee;Rebecca Gardner;David L. Porter;Chrystal U. Louis

  • Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

    Alice L. Yu;Andrew L. Gilman;M. Fevzi Ozkaynak;Wendy B. London

  • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

    David L. Porter;Wei-Ting Hwang;Noelle V. Frey;Simon F. Lacey

  • CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

    Haydar Frangoul;David Altshuler;M. Domenica Cappellini;Yi-Shan Chen

  • Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

    Michael C. Milone;Jonathan D. Fish;Jonathan D. Fish;Carmine Carpenito;Richard G. Carroll

  • Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

    M. A. Goodell;M. Rosenzweig;Hyung Kim;D. F. Marks

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

    David T. Teachey;David T. Teachey;Simon F. Lacey;Pamela A. Shaw;J. Joseph Melenhorst

  • Antibody-modified T cells: CARs take the front seat for hematologic malignancies

    Marcela V. Maus;Stephan A. Grupp;Stephan A. Grupp;David L. Porter;Carl H. June

  • Managing cytokine release syndrome associated with novel T cell-engaging therapies.

    Shannon L. Maude;David Barrett;David T. Teachey;Stephan A. Grupp

  • Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

    Kathryn G. Roberts;Ryan D. Morin;Jinghui Zhang;Martin Hirst

  • CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

    Shannon L. Maude;David T. Teachey;David L. Porter;Stephan A. Grupp;Stephan A. Grupp

  • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy.

    David T. Teachey;David T. Teachey;Susan R. Rheingold;Susan R. Rheingold;Shannon L. Maude;Shannon L. Maude;Gerhard Zugmaier

  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    Marco Ruella;Jun Xu;David M. Barrett;Joseph A. Fraietta

  • Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

    Marco Ruella;David M. Barrett;Saad S. Kenderian;Olga Shestova

Frequent Co-Authors

David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
Carl H. June
Carl H. June University of Pennsylvania
David T. Teachey
David T. Teachey Children's Hospital of Philadelphia
David L. Porter
David L. Porter University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
Simon F. Lacey
Simon F. Lacey University of Pennsylvania
Michael A. Pulsipher
Michael A. Pulsipher University of Utah
Paul G. Richardson
Paul G. Richardson Harvard University
Nancy A. Kernan
Nancy A. Kernan Memorial Sloan Kettering Cancer Center
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania

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