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Molecular Biology
USA
2026

D-Index & Metrics

Immunology

D-Index
136
Citations
68094
World Ranking
187
National Ranking
121

Molecular Biology

D-Index
132
Citations
65288
World Ranking
173
National Ranking
109

Medicine

D-Index
136
Citations
68332
World Ranking
1979
National Ranking
1122

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2016 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Malcolm K. Brenner is affiliated with the Baylor College of Medicine in the United States. Their research primarily spans the fields of medicine, biochemistry, genetics and molecular biology, as well as immunology and microbiology. Within these areas, their work focuses notably on oncology, immunology, genetics, molecular biology, and hematology.

The scientist has contributed extensively to several core topics including CAR-T cell therapy research, virus-based gene therapy research, immune cell function and interaction, viral infectious diseases and gene expression in insects, T-cell and B-cell immunology, immunotherapy and immune responses, and silicon carbide semiconductor technologies.

Malcolm K. Brenner's frequent co-authors include Helen E. Heslop, Bambi Grilley, Maksim Mamonkin, Huimin Zhang, and Premal Lulla. Their collaboration with these researchers appears across multiple publications, reflecting a sustained research network.

Their publications have appeared in key academic venues such as Blood, Journal of Clinical Oncology, Molecular Therapy, Transplantation and Cellular Therapy, and Journal for ImmunoTherapy of Cancer.

Selected recent papers include:

  • Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma, 2020, Journal of Clinical Oncology
  • Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma, 2020, Nature Communications
  • Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors, 2020, Molecular Therapy
  • Engineered off-the-shelf therapeutic T cells resist host immune rejection, 2020, Nature Biotechnology
  • Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers, 2024, Nature

This scientist's work focuses heavily on therapeutic approaches involving CAR T cells and immunotherapy strategies against various cancers and cellular immune challenges.

Awards recognizing their contributions include membership in the National Academy of Medicine since 2016 and membership in the Association of American Physicians.

Best Publications

  • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

    Edwin M. Horwitz;Darwin J. Prockop;Lorraine A. Fitzpatrick;Winston W. K. Koo

  • A distinct "side population" of cells with high drug efflux capacity in human tumor cells.

    C. Hirschmann-Jax;Aaron E. Foster;G. G. Wulf;G. G. Wulf;J. G. Nuchtern

  • Inducible apoptosis as a safety switch for adoptive cell therapy

    Antonio Di Stasi;Siok Keen Tey;Gianpietro Dotti;Yuriko Fujita

  • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

    Martin A. Pule;Barbara Savoldo;G. Doug Myers;G. Doug Myers;Claudia Rossig

  • Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.

    C.M Rooney;C.Y.C Ng;S Loftin;C.A Smith

  • Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

    Chrystal U. Louis;Chrystal U. Louis;Barbara Savoldo;Barbara Savoldo;Gianpietro Dotti;Gianpietro Dotti;Martin Pule

  • Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

    Cliona M. Rooney;Colton A. Smith;Colton A. Smith;Catherine Y.C. Ng;Catherine Y.C. Ng;Susan K. Loftin;Susan K. Loftin

  • CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

    Barbara Savoldo;Carlos Almeida Ramos;Carlos Almeida Ramos;Enli Liu;Martha P. Mims

  • Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

    M.K Brenner;D.R Rill;R.A Krance;J.N Ihle

  • Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

    Nabil Ahmed;Vita S. Brawley;Meenakshi Hegde;Catherine Robertson

  • Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

    Helen E. Heslop;Catherine Y.C. Ng;Congfen Li;Colton A. Smith

  • Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

    Helen E. Heslop;Karen S. Slobod;Martin A. Pule;Gregory A. Hale

  • An inducible caspase 9 safety switch for T-cell therapy

    Karin C. Straathof;Martin A. Pulè;Patricia Yotnda;Gianpietro Dotti

  • HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial

    Nabil Ahmed;Nabil Ahmed;Vita Brawley;Vita Brawley;Meenakshi Hegde;Meenakshi Hegde;Kevin Bielamowicz

  • Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta

    Edwin M. Horwitz;Darwin J. Prockop;Patricia L. Gordon;Winston W. K. Koo

  • Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

    Meenakshi Hegde;Malini Mukherjee;Malini Mukherjee;Zakaria Grada;Antonella Pignata

  • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.

    Ann M. Leen;G. Doug Myers;Uluhan Sili;M. Helen Huls

  • Design and development of therapies using chimeric antigen receptor-expressing T cells

    Gianpietro Dotti;Stephen Gottschalk;Barbara Savoldo;Malcolm K. Brenner

  • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

    Valentina Hoyos;Barbara Savoldo;Barbara Savoldo;Concetta Quintarelli;Aruna Mahendravada

  • Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation

    Ann M. Leen;Catherine M. Bollard;Adam M. Mendizabal;Elizabeth J. Shpall

Frequent Co-Authors

Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Catherine M. Bollard
Catherine M. Bollard George Washington University
Ann M. Leen
Ann M. Leen Baylor College of Medicine
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
Barbara Savoldo
Barbara Savoldo University of North Carolina at Chapel Hill
Hao Liu
Hao Liu Indiana University
A. V. Hoffbrand
A. V. Hoffbrand The Royal Free Hospital

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