D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 129 Citations 59,538 486 World Ranking 83 National Ranking 57
Medicine D-index 134 Citations 63,432 588 World Ranking 870 National Ranking 522

Research.com Recognitions

Awards & Achievements

2016 - Member of the National Academy of Medicine (NAM)

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Cancer
  • Immune system
  • Gene

Immunology, Cytotoxic T cell, Antigen, Immunotherapy and Transplantation are his primary areas of study. Immunology is closely attributed to Hematopoietic stem cell transplantation in his work. He has included themes like Cancer research and Virology in his Cytotoxic T cell study.

He works mostly in the field of Antigen, limiting it down to concerns involving Chimeric antigen receptor and, occasionally, CD30, Antibody and Receptor. His research investigates the connection with Immunotherapy and areas like Neuroblastoma which intersect with concerns in Bone marrow neoplasm. His Transplantation research is multidisciplinary, incorporating perspectives in Stem cell and Bone marrow.

His most cited work include:

  • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta (1681 citations)
  • A distinct "side population" of cells with high drug efflux capacity in human tumor cells. (1111 citations)
  • Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. (1058 citations)

What are the main themes of his work throughout his whole career to date?

Malcolm K. Brenner spends much of his time researching Immunology, Antigen, Cytotoxic T cell, Cancer research and Immunotherapy. His study looks at the relationship between Immunology and fields such as Transplantation, as well as how they intersect with chemical problems. Malcolm K. Brenner interconnects Molecular biology, Chimeric antigen receptor, Antibody and Virology in the investigation of issues within Antigen.

His biological study spans a wide range of topics, including Epstein–Barr virus and CD8. His Cancer research research integrates issues from Cytokine, CD40, Receptor, Suicide gene and Leukemia. His work on Lymphoma expands to the thematically related Immunotherapy.

He most often published in these fields:

  • Immunology (62.31%)
  • Antigen (33.29%)
  • Cytotoxic T cell (32.29%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cancer research (29.90%)
  • Immunology (62.31%)
  • Chimeric antigen receptor (15.70%)

In recent papers he was focusing on the following fields of study:

Malcolm K. Brenner mainly focuses on Cancer research, Immunology, Chimeric antigen receptor, Antigen and T cell. His Cancer research research is multidisciplinary, incorporating elements of Cell culture, Receptor and Immunotherapy. His Immunotherapy research is multidisciplinary, relying on both Transgene and In vivo.

His research in Immunology intersects with topics in Cytotoxic T cell and Hematopoietic stem cell transplantation. His studies in Chimeric antigen receptor integrate themes in fields like Progenitor cell, Cell, Cytokine and CD30. His work deals with themes such as Chemotherapy, PRAME, Lymphoma, Leukemia and Tumor antigen, which intersect with Antigen.

Between 2014 and 2021, his most popular works were:

  • Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma (500 citations)
  • Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape. (269 citations)
  • HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial (249 citations)

In his most recent research, the most cited papers focused on:

  • Cancer
  • Immune system
  • Internal medicine

Malcolm K. Brenner mainly investigates Cancer research, Chimeric antigen receptor, Immunology, Antigen and T cell. His Cancer research research includes elements of Cytokine receptor and Immunotherapy. His Chimeric antigen receptor research incorporates elements of Cytokine, Progenitor cell, CD28, Myeloid leukemia and Lymphoma.

The various areas that Malcolm K. Brenner examines in his Immunology study include Hematopoietic stem cell and Suicide gene. His Antigen study integrates concerns from other disciplines, such as Cell culture, Leukemia, Tumor antigen and CD30. The study incorporates disciplines such as Cytotoxic T cell, CD5, Long terminal repeat and Cell biology in addition to T cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

Edwin M. Horwitz;Darwin J. Prockop;Lorraine A. Fitzpatrick;Winston W. K. Koo.
Nature Medicine (1999)

2388 Citations

A distinct "side population" of cells with high drug efflux capacity in human tumor cells.

C. Hirschmann-Jax;Aaron E. Foster;G. G. Wulf;G. G. Wulf;J. G. Nuchtern.
Proceedings of the National Academy of Sciences of the United States of America (2004)

1596 Citations

Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.

C.M Rooney;C.Y.C Ng;S Loftin;C.A Smith.
The Lancet (1995)

1279 Citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

Cliona M. Rooney;Colton A. Smith;Colton A. Smith;Catherine Y.C. Ng;Catherine Y.C. Ng;Susan K. Loftin;Susan K. Loftin.
Blood (1998)

1279 Citations

Inducible apoptosis as a safety switch for adoptive cell therapy

Antonio Di Stasi;Siok Keen Tey;Gianpietro Dotti;Yuriko Fujita.
The New England Journal of Medicine (2011)

1233 Citations

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation

M.K Brenner;D.R Rill;R.A Krance;J.N Ihle.
The Lancet (1993)

1156 Citations

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

Martin A. Pule;Barbara Savoldo;G. Doug Myers;G. Doug Myers;Claudia Rossig.
Nature Medicine (2008)

1149 Citations

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Barbara Savoldo;Carlos Almeida Ramos;Carlos Almeida Ramos;Enli Liu;Martha P. Mims.
Journal of Clinical Investigation (2011)

971 Citations

Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

Chrystal U. Louis;Chrystal U. Louis;Barbara Savoldo;Barbara Savoldo;Gianpietro Dotti;Gianpietro Dotti;Martin Pule.
Blood (2011)

960 Citations

Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes

Helen E. Heslop;Catherine Y.C. Ng;Congfen Li;Colton A. Smith.
Nature Medicine (1996)

959 Citations

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