D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 58 Citations 10,312 146 World Ranking 1919 National Ranking 944

Overview

What is she best known for?

The fields of study she is best known for:

  • Immune system
  • Cancer
  • Virus

The scientist’s investigation covers issues in Immunology, Immunotherapy, Antigen, Virology and Adoptive cell transfer. Her work carried out in the field of Immunology brings together such families of science as Cytotoxic T cell and Hematopoietic stem cell transplantation, Transplantation. Her research in Cytotoxic T cell intersects with topics in T lymphocyte, CD8 and Cell therapy.

As a member of one scientific family, Ann M. Leen mostly works in the field of Immunotherapy, focusing on Genetic enhancement and, on occasion, Virotherapy, Immune tolerance, Oncolytic virus and ELISPOT. She combines subjects such as Epitope and Cellular immunity with her study of Virology. Her Adoptive cell transfer research includes elements of Cytomegalovirus and Graft-versus-host disease.

Her most cited work include:

  • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. (462 citations)
  • Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation (350 citations)
  • Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. (259 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include Immunology, Antigen, Cytotoxic T cell, T cell and Virology. Immunology is frequently linked to Hematopoietic stem cell transplantation in her study. Ann M. Leen has included themes like Adoptive cell transfer and Cancer research in her Antigen study.

Her T cell research is multidisciplinary, relying on both Molecular biology and Oncology. Her Virology study combines topics from a wide range of disciplines, such as Cellular immunity and Virus-specific Cytotoxic T-lymphocytes. Her Immunotherapy research incorporates elements of Viral vector and Lymphoma.

She most often published in these fields:

  • Immunology (74.44%)
  • Antigen (48.52%)
  • Cytotoxic T cell (42.96%)

What were the highlights of her more recent work (between 2017-2021)?

  • Antigen (48.52%)
  • T cell (40.37%)
  • Cancer research (21.11%)

In recent papers she was focusing on the following fields of study:

Ann M. Leen mostly deals with Antigen, T cell, Cancer research, Immunology and Adoptive cell transfer. The concepts of her Antigen study are interwoven with issues in Cytotoxic T cell, PRAME, Cytokine and Survivin. Her Cancer research study integrates concerns from other disciplines, such as Car t cells, Human leukocyte antigen and Immunotherapy.

Her research integrates issues of Allogeneic hematopoietic stem cell transplant and Peripheral blood mononuclear cell in her study of Immunology. Her studies examine the connections between Adoptive cell transfer and genetics, as well as such issues in Chimeric antigen receptor, with regards to Interleukin 4, Prostate Stem Cell Antigen and Graft-versus-host disease. The various areas that Ann M. Leen examines in her CD8 study include Epitope and Virology.

Between 2017 and 2021, her most popular works were:

  • Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment (48 citations)
  • CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation (39 citations)
  • Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE) (27 citations)

In her most recent research, the most cited papers focused on:

  • Cancer
  • Immune system
  • Virus

Ann M. Leen mainly investigates Antigen, Cancer research, Immunotherapy, Cytotoxic T cell and Stem cell. Her study explores the link between Cancer research and topics such as Adoptive cell transfer that cross with problems in Interleukin 4 and Cytokine. Her Immunotherapy research includes themes of Epstein–Barr virus, Human leukocyte antigen, Epitope, Epitope mapping and Major histocompatibility complex.

Many of her studies involve connections with topics such as Immunology and Cytotoxic T cell. Her work deals with themes such as Hematopoietic stem cell and Pneumonia, which intersect with Immunology. The various areas that Ann M. Leen examines in her Hematopoietic stem cell transplantation study include Virus, Immune system, Myeloid leukemia and Transplant Conditioning.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.

Ann M. Leen;G. Doug Myers;Uluhan Sili;M. Helen Huls.
Nature Medicine (2006)

566 Citations

Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation

Ann M. Leen;Catherine M. Bollard;Adam M. Mendizabal;Elizabeth J. Shpall.
Blood (2013)

437 Citations

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

Ann M. Leen;Anne Christin;Gary D. Myers;Hao Liu.
Blood (2009)

390 Citations

Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT

Anastasia Papadopoulou;Ulrike Gerdemann;Usha L. Katari;Ifigenia Tzannou.
Science Translational Medicine (2014)

365 Citations

Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.

Catherine M. Bollard;Stephen Gottschalk;Ann M. Leen;Heidi Weiss.
Blood (2007)

319 Citations

Functionally active virus-specific T-cells that target CMV, adenovirus and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

Patrick J. Hanley;Conrad Russell Young Cruz;Barbara Savoldo;Ann M. Leen.
Blood (2009)

317 Citations

Improving T cell therapy for cancer.

Ann M. Leen;Cliona M. Rooney;Aaron E. Foster.
Annual Review of Immunology (2007)

285 Citations

Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation

Ifigeneia Tzannou;Anastasia Papadopoulou;Swati Naik;Kathryn Leung.
Journal of Clinical Oncology (2017)

266 Citations

Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses

Ann Leen;Pauline Meij;Irina Redchenko;Jaap Middeldorp.
Journal of Virology (2001)

263 Citations

Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

Ulrike Gerdemann;Jacqueline M Keirnan;Usha L Katari;Ryu Yanagisawa.
Molecular Therapy (2012)

196 Citations

Best Scientists Citing Ann M. Leen

Catherine M. Bollard

Catherine M. Bollard

George Washington University

Publications: 144

Cliona M. Rooney

Cliona M. Rooney

Baylor College of Medicine

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Helen E. Heslop

Helen E. Heslop

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Malcolm K. Brenner

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Gianpietro Dotti

Gianpietro Dotti

University of North Carolina at Chapel Hill

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Stephen Gottschalk

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St. Jude Children's Research Hospital

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Elizabeth J. Shpall

Elizabeth J. Shpall

The University of Texas MD Anderson Cancer Center

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Carl H. June

Carl H. June

University of Pennsylvania

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Adrian P. Gee

Adrian P. Gee

Baylor College of Medicine

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Rajiv Khanna

Rajiv Khanna

QIMR Berghofer Medical Research Institute

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Michael Boeckh

Michael Boeckh

Fred Hutchinson Cancer Research Center

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Franco Locatelli

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Bambino Gesù Children's Hospital

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Laurence J.N. Cooper

Laurence J.N. Cooper

The University of Texas MD Anderson Cancer Center

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Akseli Hemminki

Akseli Hemminki

University of Helsinki

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Karl S. Peggs

Karl S. Peggs

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Christian Münz

Christian Münz

University of Zurich

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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