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Immunology

D-Index
62
Citations
12855
World Ranking
3149
National Ranking
1477

Overview

Ann M. Leen is affiliated with Baylor College of Medicine in the United States. Their research primarily spans the fields of medicine and immunology and microbiology, with particular focus on subfields including oncology, immunology, epidemiology, infectious diseases, and genetics.

The main topics of their work cover:

  • CAR-T cell therapy research
  • Cytomegalovirus and herpesvirus research
  • Immune Cell Function and Interaction
  • Virus-based gene therapy research
  • Immunotherapy and Immune Responses
  • Hematopoietic Stem Cell Transplantation
  • SARS-CoV-2 and COVID-19 Research

Their recent publications include the following papers:

  • "Posoleucel, an Allogeneic, Off-the-Shelf Multivirus-Specific T-Cell Therapy, for the Treatment of Refractory Viral Infections in the Post-HCT Setting" (2023), published in Clinical Cancer Research
  • "Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer" (2021), published in Journal for ImmunoTherapy of Cancer
  • "Clinical effects of administering leukemia-specific donor T cells to patients with AML/MDS after allogeneic transplant" (2020), published in Blood
  • "LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study" (2024), published in The Lancet Oncology
  • "T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects" (2021), published in Journal of Clinical Oncology

Frequent co-authors who have collaborated with Ann M. Leen include:

  • Spyridoula Vasileiou
  • Manik Kuvalekar
  • Premal Lulla
  • Ayumi Watanabe
  • Helen E. Heslop

The most common venues for their publications are:

  • Blood
  • Transplantation and Cellular Therapy
  • Cytotherapy
  • Journal of Clinical Oncology
  • Blood Advances

Best Publications

  • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.

    Ann M. Leen;G. Doug Myers;Uluhan Sili;M. Helen Huls

  • Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation

    Ann M. Leen;Catherine M. Bollard;Adam M. Mendizabal;Elizabeth J. Shpall

  • Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation

    Ifigeneia Tzannou;Anastasia Papadopoulou;Swati Naik;Kathryn Leung

  • Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT

    Anastasia Papadopoulou;Ulrike Gerdemann;Usha L. Katari;Ifigenia Tzannou

  • Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

    Ann M. Leen;Anne Christin;Gary D. Myers;Hao Liu

  • Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.

    Catherine M. Bollard;Stephen Gottschalk;Ann M. Leen;Heidi Weiss

  • Functionally active virus-specific T-cells that target CMV, adenovirus and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

    Patrick J. Hanley;Conrad Russell Young Cruz;Barbara Savoldo;Ann M. Leen

  • Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer.

    Somala Mohammed;Sujita Sukumaran;Pradip Bajgain;Pradip Bajgain;Norihiro Watanabe

  • Improving T cell therapy for cancer.

    Ann M. Leen;Cliona M. Rooney;Aaron E. Foster

  • Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses

    Ann Leen;Pauline Meij;Irina Redchenko;Jaap Middeldorp

  • Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

    Ulrike Gerdemann;Jacqueline M Keirnan;Usha L Katari;Ryu Yanagisawa

  • Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant

    Ulrike Gerdemann;Usha L Katari;Anastasia Papadopoulou;Jacqueline M Keirnan

  • How I treat adenovirus in hematopoietic stem cell transplant recipients

    Caroline A. Lindemans;Ann M. Leen;Jaap Jan Boelens

  • Fine-tuning the CAR spacer improves T-cell potency

    Norihiro Watanabe;Pradip Bajgain;Sujita Sukumaran;Salma Ansari

  • Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

    Ann M Leen;Sujita Sukumaran;Norihiro Watanabe;Somala Mohammed

  • Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.

    J. Joseph Melenhorst;Ann M. Leen;Catherine M. Bollard;Máire F. Quigley;Máire F. Quigley

  • Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy.

    Ann M. Leen;Anne Christin;Mariam Khalil;Heidi Weiss

  • Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (g-rex)

    Juan F. Vera;Lara J. Brenner;Lara J. Brenner;Ulrike Gerdemann;Ulrike Gerdemann;Minhtran C. Ngo;Minhtran C. Ngo

  • Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene.

    Xiaoou Zhou;Xiaoou Zhou;Antonio Di Stasi;Antonio Di Stasi;Siok Keen Tey;Siok Keen Tey;Robert A. Krance;Robert A. Krance

  • Adenovirus as an emerging pathogen in immunocompromised patients

    Ann M. Leen;Cliona M. Rooney

  • Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients.

    Sari Pesonen;Iulia Diaconu;Lotta Kangasniemi;Tuuli Ranki

Frequent Co-Authors

Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Malcolm K. Brenner
Malcolm K. Brenner Baylor College of Medicine
Catherine M. Bollard
Catherine M. Bollard George Washington University
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Hao Liu
Hao Liu Indiana University
Barbara Savoldo
Barbara Savoldo University of North Carolina at Chapel Hill
Elizabeth J. Shpall
Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center

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