What is she best known for?
The fields of study she is best known for:
- Immune system
- Cancer
- Virus
The scientist’s investigation covers issues in Immunology, Immunotherapy, Antigen, Virology and Adoptive cell transfer.
Her work carried out in the field of Immunology brings together such families of science as Cytotoxic T cell and Hematopoietic stem cell transplantation, Transplantation.
Her research in Cytotoxic T cell intersects with topics in T lymphocyte, CD8 and Cell therapy.
As a member of one scientific family, Ann M. Leen mostly works in the field of Immunotherapy, focusing on Genetic enhancement and, on occasion, Virotherapy, Immune tolerance, Oncolytic virus and ELISPOT.
She combines subjects such as Epitope and Cellular immunity with her study of Virology.
Her Adoptive cell transfer research includes elements of Cytomegalovirus and Graft-versus-host disease.
Her most cited work include:
- Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. (462 citations)
- Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation (350 citations)
- Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. (259 citations)
What are the main themes of her work throughout her whole career to date?
Her primary areas of investigation include Immunology, Antigen, Cytotoxic T cell, T cell and Virology.
Immunology is frequently linked to Hematopoietic stem cell transplantation in her study.
Ann M. Leen has included themes like Adoptive cell transfer and Cancer research in her Antigen study.
Her T cell research is multidisciplinary, relying on both Molecular biology and Oncology.
Her Virology study combines topics from a wide range of disciplines, such as Cellular immunity and Virus-specific Cytotoxic T-lymphocytes.
Her Immunotherapy research incorporates elements of Viral vector and Lymphoma.
She most often published in these fields:
- Immunology (74.44%)
- Antigen (48.52%)
- Cytotoxic T cell (42.96%)
What were the highlights of her more recent work (between 2017-2021)?
- Antigen (48.52%)
- T cell (40.37%)
- Cancer research (21.11%)
In recent papers she was focusing on the following fields of study:
Ann M. Leen mostly deals with Antigen, T cell, Cancer research, Immunology and Adoptive cell transfer.
The concepts of her Antigen study are interwoven with issues in Cytotoxic T cell, PRAME, Cytokine and Survivin.
Her Cancer research study integrates concerns from other disciplines, such as Car t cells, Human leukocyte antigen and Immunotherapy.
Her research integrates issues of Allogeneic hematopoietic stem cell transplant and Peripheral blood mononuclear cell in her study of Immunology.
Her studies examine the connections between Adoptive cell transfer and genetics, as well as such issues in Chimeric antigen receptor, with regards to Interleukin 4, Prostate Stem Cell Antigen and Graft-versus-host disease.
The various areas that Ann M. Leen examines in her CD8 study include Epitope and Virology.
Between 2017 and 2021, her most popular works were:
- Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment (48 citations)
- CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation (39 citations)
- Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE) (27 citations)
In her most recent research, the most cited papers focused on:
- Cancer
- Immune system
- Virus
Ann M. Leen mainly investigates Antigen, Cancer research, Immunotherapy, Cytotoxic T cell and Stem cell.
Her study explores the link between Cancer research and topics such as Adoptive cell transfer that cross with problems in Interleukin 4 and Cytokine.
Her Immunotherapy research includes themes of Epstein–Barr virus, Human leukocyte antigen, Epitope, Epitope mapping and Major histocompatibility complex.
Many of her studies involve connections with topics such as Immunology and Cytotoxic T cell.
Her work deals with themes such as Hematopoietic stem cell and Pneumonia, which intersect with Immunology.
The various areas that Ann M. Leen examines in her Hematopoietic stem cell transplantation study include Virus, Immune system, Myeloid leukemia and Transplant Conditioning.
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