The scientist’s investigation covers issues in Immunology, Immunotherapy, Antigen, Virology and Adoptive cell transfer. Her work carried out in the field of Immunology brings together such families of science as Cytotoxic T cell and Hematopoietic stem cell transplantation, Transplantation. Her research in Cytotoxic T cell intersects with topics in T lymphocyte, CD8 and Cell therapy.
As a member of one scientific family, Ann M. Leen mostly works in the field of Immunotherapy, focusing on Genetic enhancement and, on occasion, Virotherapy, Immune tolerance, Oncolytic virus and ELISPOT. She combines subjects such as Epitope and Cellular immunity with her study of Virology. Her Adoptive cell transfer research includes elements of Cytomegalovirus and Graft-versus-host disease.
Her primary areas of investigation include Immunology, Antigen, Cytotoxic T cell, T cell and Virology. Immunology is frequently linked to Hematopoietic stem cell transplantation in her study. Ann M. Leen has included themes like Adoptive cell transfer and Cancer research in her Antigen study.
Her T cell research is multidisciplinary, relying on both Molecular biology and Oncology. Her Virology study combines topics from a wide range of disciplines, such as Cellular immunity and Virus-specific Cytotoxic T-lymphocytes. Her Immunotherapy research incorporates elements of Viral vector and Lymphoma.
Ann M. Leen mostly deals with Antigen, T cell, Cancer research, Immunology and Adoptive cell transfer. The concepts of her Antigen study are interwoven with issues in Cytotoxic T cell, PRAME, Cytokine and Survivin. Her Cancer research study integrates concerns from other disciplines, such as Car t cells, Human leukocyte antigen and Immunotherapy.
Her research integrates issues of Allogeneic hematopoietic stem cell transplant and Peripheral blood mononuclear cell in her study of Immunology. Her studies examine the connections between Adoptive cell transfer and genetics, as well as such issues in Chimeric antigen receptor, with regards to Interleukin 4, Prostate Stem Cell Antigen and Graft-versus-host disease. The various areas that Ann M. Leen examines in her CD8 study include Epitope and Virology.
Ann M. Leen mainly investigates Antigen, Cancer research, Immunotherapy, Cytotoxic T cell and Stem cell. Her study explores the link between Cancer research and topics such as Adoptive cell transfer that cross with problems in Interleukin 4 and Cytokine. Her Immunotherapy research includes themes of Epstein–Barr virus, Human leukocyte antigen, Epitope, Epitope mapping and Major histocompatibility complex.
Many of her studies involve connections with topics such as Immunology and Cytotoxic T cell. Her work deals with themes such as Hematopoietic stem cell and Pneumonia, which intersect with Immunology. The various areas that Ann M. Leen examines in her Hematopoietic stem cell transplantation study include Virus, Immune system, Myeloid leukemia and Transplant Conditioning.
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Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Ann M. Leen;G. Doug Myers;Uluhan Sili;M. Helen Huls.
Nature Medicine (2006)
Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation
Ann M. Leen;Catherine M. Bollard;Adam M. Mendizabal;Elizabeth J. Shpall.
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation
Ann M. Leen;Anne Christin;Gary D. Myers;Hao Liu.
Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT
Anastasia Papadopoulou;Ulrike Gerdemann;Usha L. Katari;Ifigenia Tzannou.
Science Translational Medicine (2014)
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation
Ifigeneia Tzannou;Anastasia Papadopoulou;Swati Naik;Kathryn Leung.
Journal of Clinical Oncology (2017)
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
Catherine M. Bollard;Stephen Gottschalk;Ann M. Leen;Heidi Weiss.
Functionally active virus-specific T-cells that target CMV, adenovirus and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes
Patrick J. Hanley;Conrad Russell Young Cruz;Barbara Savoldo;Ann M. Leen.
Improving T cell therapy for cancer.
Ann M. Leen;Cliona M. Rooney;Aaron E. Foster.
Annual Review of Immunology (2007)
Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses
Ann Leen;Pauline Meij;Irina Redchenko;Jaap Middeldorp.
Journal of Virology (2001)
Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer.
Somala Mohammed;Sujita Sukumaran;Pradip Bajgain;Pradip Bajgain;Norihiro Watanabe.
Molecular Therapy (2017)
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